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Title: :  Invasion inhibitory antimalarial activity of Macrolides
PaperId: :  12486
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 4 2020
DUI:    16.0415/IJARIIE-12486
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Sumeet GuptaIndependent Researcher, BDS, Chandigarh India
Swati GuptaIndependent Researcher, MDS, Chandigarh India
Minoti GuptaIndependent Researcher, M.Sc Hons, Panjab University, Chandigarh India
Richa GuptaAssistant Professor, Deptt of Anatomy, Pgimer , Chandigarh. India

Abstract

Bioinformatics
Plasmodium, merozoute, azithromycin, invasion
Background: Malarial drug resistance is becoming a serious concern. Drug designing is a cumbersome and time taking process. The need of hour is to repurpose the existing drugs. The invasion inhibitory potential of Azithromycin has long been known through in-vitro and in-vivo studies. Here we intended to study the invasion inhibitory potential of drugs belonging to the class of macrolideantibiotics. Methodology: Molecular docking study was performed with fourteen drug molecules.The three-dimensional chemical structures of molecules were prepared through UCSF Chimera and Autodock Tools freeware. Molecular docking study was performed using AutoDockvina, Discovery studio 4.5 and PyMol was used to predict the active site of target sites. Results: The preliminary experimental study demonstrated that in comparison with Azithromycin, Pristinamycinshows good binding efficacy to all the target proteins. Hence, it can be suggested thar Pristinamycinis a potential inhibitor of merozoite invasion into erythrocytes. However, detailed in-vitro and in-vivo studies needs to be performed for further drug development process.

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IJARIIE Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. "Invasion inhibitory antimalarial activity of Macrolides" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 4 2020 Page 1425-1435
MLA Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. "Invasion inhibitory antimalarial activity of Macrolides." International Journal Of Advance Research And Innovative Ideas In Education 6.4(2020) : 1425-1435.
APA Sumeet Gupta, Swati Gupta, Minoti Gupta, & Richa Gupta. (2020). Invasion inhibitory antimalarial activity of Macrolides. International Journal Of Advance Research And Innovative Ideas In Education, 6(4), 1425-1435.
Chicago Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. "Invasion inhibitory antimalarial activity of Macrolides." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 4 (2020) : 1425-1435.
Oxford Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. 'Invasion inhibitory antimalarial activity of Macrolides', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, 2020, p. 1425-1435. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Invasion_inhibitory_antimalarial_activity_of_Macrolides_ijariie12486.pdf (Accessed : ).
Harvard Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. (2020) 'Invasion inhibitory antimalarial activity of Macrolides', International Journal Of Advance Research And Innovative Ideas In Education, 6(4), pp. 1425-1435IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Invasion_inhibitory_antimalarial_activity_of_Macrolides_ijariie12486.pdf (Accessed : )
IEEE Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta, "Invasion inhibitory antimalarial activity of Macrolides," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, pp. 1425-1435, Jul-Aug 2020. [Online]. Available: http://ijariie.com/AdminUploadPdf/Invasion_inhibitory_antimalarial_activity_of_Macrolides_ijariie12486.pdf [Accessed : ].
Turabian Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. "Invasion inhibitory antimalarial activity of Macrolides." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 4 ().
Vancouver Sumeet Gupta, Swati Gupta, Minoti Gupta, and Richa Gupta. Invasion inhibitory antimalarial activity of Macrolides. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : ]; 6(4) : 1425-1435. Available from: http://ijariie.com/AdminUploadPdf/Invasion_inhibitory_antimalarial_activity_of_Macrolides_ijariie12486.pdf
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