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Title: :  “ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”
PaperId: :  13552
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 5 Issue 1 2019
DUI:    16.0415/IJARIIE-13552
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Satya Narayan GoswamiBhagwant University
Dr. Shiv GargMaharishi Arvind College of Pharmacy

Abstract

Pharmacy
Pioglitazone hydrochloride, PEG 4000, cross povidone, SSG, solid dispersion, fast dissolving tablets.
The objective of the present study was to prepare fast dissolving tablets of a hypoglycemic drug Pioglitazone hydrochloride using solid dispersion. One of the major problems with this drug is its low solubility, which results in poor bioavailability after oral administration. The solubility of poorly soluble drug was enhanced by preparing solid dispersions of the drug by PEG 4000 as carrier. Solid dispersion formulations were prepared using different ratios of drug and carrier i.e. 1:1, 1:2: 1:3 and 1:4; respectively by conventional solvent evaporation method. The optimized solid dispersions were further kneaded with suitable proportions of superdisintegrants such as Crosspovidone, Sodium starch Glycolate, Crosscarmellose sodium and different diluents avicel, mannitol and lactose etc. FT-IR spectroscopy, differential scanning calorimetry and U.V spectroscopy, solubility determination, partition coefficient etc studies were carried out in order to characterize the drug and solid dispersion and it showed no evidence of drug-excipient interaction. The prepared formulations were evaluated for thickness, hardness, friability, weight variation, water absorption ratio, wetting time, in-vitro disintegration time and in-vitro dissolution studies. The maximum drug release was found in formulation PGHT8 (97.842%). It was concluded that fast dissolving tablets of pioglitazone hydrochloride prepared by solid dispersions of drug with PEG 4000 and combination of diluents and cross povidone as super disintegrant provide complete and better dissolution within in shorter period of time. Hence effective diabetic treatment anywhere, and at anytime particularly for geriatric, pediatric, mentally ill, bedridden and patients who do not have easy access to water can be done.

Citations

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IJARIIE Satya Narayan Goswami, and Dr. Shiv Garg. "“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”" International Journal Of Advance Research And Innovative Ideas In Education Volume 5 Issue 1 2019 Page 911-922
MLA Satya Narayan Goswami, and Dr. Shiv Garg. "“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”." International Journal Of Advance Research And Innovative Ideas In Education 5.1(2019) : 911-922.
APA Satya Narayan Goswami, & Dr. Shiv Garg. (2019). “ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”. International Journal Of Advance Research And Innovative Ideas In Education, 5(1), 911-922.
Chicago Satya Narayan Goswami, and Dr. Shiv Garg. "“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”." International Journal Of Advance Research And Innovative Ideas In Education 5, no. 1 (2019) : 911-922.
Oxford Satya Narayan Goswami, and Dr. Shiv Garg. '“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”', International Journal Of Advance Research And Innovative Ideas In Education, vol. 5, no. 1, 2019, p. 911-922. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/“ENHANCING_INVITRO_DRUG_RELEASE_OF_PIOGLITAZONE_USING_SUPERDISINTEGRANTS_FDT”_ijariie13552.pdf (Accessed : ).
Harvard Satya Narayan Goswami, and Dr. Shiv Garg. (2019) '“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”', International Journal Of Advance Research And Innovative Ideas In Education, 5(1), pp. 911-922IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/“ENHANCING_INVITRO_DRUG_RELEASE_OF_PIOGLITAZONE_USING_SUPERDISINTEGRANTS_FDT”_ijariie13552.pdf (Accessed : )
IEEE Satya Narayan Goswami, and Dr. Shiv Garg, "“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”," International Journal Of Advance Research And Innovative Ideas In Education, vol. 5, no. 1, pp. 911-922, Jan-Feb 2019. [Online]. Available: http://ijariie.com/AdminUploadPdf/“ENHANCING_INVITRO_DRUG_RELEASE_OF_PIOGLITAZONE_USING_SUPERDISINTEGRANTS_FDT”_ijariie13552.pdf [Accessed : ].
Turabian Satya Narayan Goswami, and Dr. Shiv Garg. "“ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 5 number 1 ().
Vancouver Satya Narayan Goswami, and Dr. Shiv Garg. “ENHANCING INVITRO DRUG RELEASE OF PIOGLITAZONE USING SUPERDISINTEGRANTS-FDT”. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2019 [Cited : ]; 5(1) : 911-922. Available from: http://ijariie.com/AdminUploadPdf/“ENHANCING_INVITRO_DRUG_RELEASE_OF_PIOGLITAZONE_USING_SUPERDISINTEGRANTS_FDT”_ijariie13552.pdf
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