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Title: :  A Study of Structural Basis of Collagen-GPVI Interaction
PaperId: :  14809
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 4 Issue 1 2018
DUI:    16.0415/IJARIIE-14809
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Suresh Yadav SinganaboinaResearch Scholar, Department of Biotechnology, Sri Satya Sai University of Technology & Medical Sciences, Sehore, M.P., India.
Dr. Syed Shahab AhmedResearch Supervisor Department of Biotechnology, Sri Satya Sai University of Technology &Medical Sciences, Sehore, M.P., India.

Abstract

Biotechnology
Collagen-GPVI Interaction, 3-dimensional aggregates, blood flow, GPVI enhances
While the immune-type GPVI receptor activates platelets, the way this receptor developed into a platelet under rapid blood flow conditions is not understood. Moreover, the preservation of collagen reactions in non-mammalian animals not expressing GPVI is not apparent. According to this research, the proline-rich GPVI domain enhances GPVI signalling kinetics and is required for maximal adherence to flow collagen. The proline-rich domain accelerates signalling by binding and directly activating the Src family Lyn kinase. Collagen stimulates chicken thrombocytes, but, in strong contrast to platelet activity, they do not form 3-dimensional aggregates under circumstances of arterial flow. Despite being selective, thrombocytes exhibit a decreased integrin density of 2b3 on the cell's surface, with most platelet-specific genes expressed. These results reveal that the GPVI enhances immune signalling kinetics by means of a novel molecular mechanism and demonstrate that weather-cell responses to collagen under flow are partly maintained. In conjunction with stimulus-specific tyrosine phosphorylation of the GPVI/FcR-chain complex and/or CLEC-2, Src and Syk tyrosine kinases are responsible for aggregation of human and mouse platelet. Receptor-deficient platelets show a key role in mediating aggregation for GPVI and/or CLEC-2.

Citations

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IJARIIE Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. "A Study of Structural Basis of Collagen-GPVI Interaction" International Journal Of Advance Research And Innovative Ideas In Education Volume 4 Issue 1 2018 Page 1493-1499
MLA Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. "A Study of Structural Basis of Collagen-GPVI Interaction." International Journal Of Advance Research And Innovative Ideas In Education 4.1(2018) : 1493-1499.
APA Suresh Yadav Singanaboina, & Dr. Syed Shahab Ahmed. (2018). A Study of Structural Basis of Collagen-GPVI Interaction. International Journal Of Advance Research And Innovative Ideas In Education, 4(1), 1493-1499.
Chicago Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. "A Study of Structural Basis of Collagen-GPVI Interaction." International Journal Of Advance Research And Innovative Ideas In Education 4, no. 1 (2018) : 1493-1499.
Oxford Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. 'A Study of Structural Basis of Collagen-GPVI Interaction', International Journal Of Advance Research And Innovative Ideas In Education, vol. 4, no. 1, 2018, p. 1493-1499. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/A_Study_of_Structural_Basis_of_Collagen_GPVI_Interaction_ijariie14809.pdf (Accessed : 01 July 2021).
Harvard Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. (2018) 'A Study of Structural Basis of Collagen-GPVI Interaction', International Journal Of Advance Research And Innovative Ideas In Education, 4(1), pp. 1493-1499IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/A_Study_of_Structural_Basis_of_Collagen_GPVI_Interaction_ijariie14809.pdf (Accessed : 01 July 2021)
IEEE Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed, "A Study of Structural Basis of Collagen-GPVI Interaction," International Journal Of Advance Research And Innovative Ideas In Education, vol. 4, no. 1, pp. 1493-1499, Jan-Feb 2018. [Online]. Available: http://ijariie.com/AdminUploadPdf/A_Study_of_Structural_Basis_of_Collagen_GPVI_Interaction_ijariie14809.pdf [Accessed : 01 July 2021].
Turabian Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. "A Study of Structural Basis of Collagen-GPVI Interaction." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 4 number 1 (01 July 2021).
Vancouver Suresh Yadav Singanaboina, and Dr. Syed Shahab Ahmed. A Study of Structural Basis of Collagen-GPVI Interaction. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2018 [Cited : 01 July 2021]; 4(1) : 1493-1499. Available from: http://ijariie.com/AdminUploadPdf/A_Study_of_Structural_Basis_of_Collagen_GPVI_Interaction_ijariie14809.pdf
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