Call for Papers:Vol.11 Issue.3

Submission
Last date		 28-Jun-2025
Acceptance Status In One Day
Paper Publish In Two Days
Submit ManuScript

News & Updates

Submit Article

Dear Authors, Article publish in our journal for Volume-11,Issue-3. For article submission on below link: Submit Manuscript


Join As Board

Dear Reviewer, You can join our Reviewer team without given any charges in our journal. Submit Details on below link: Join As Board


Paper Publication Charges

IJARIIE APP
Download Android App

For Authors

Archives

IJARIIE Board

Downloads

Android App

Download IJARIIE APP

Authors

Title: :  Bio- Chemical and Molecular Mechanisms of Vitamin D
PaperId: :  17856
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 4 2020
DUI:    16.0415/IJARIIE-17856
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Neha PatelResearch Scholar, Sri Satya Sai University of Technology & Medical Sciences, Sehore
Dr. Syed Shahab AhmadResearch Supervisor, Sri Satya Sai University of Technology & Medical Sciences, Sehore

Abstract

biotechnology
Vitamin D, Gene, Expression, Biological, Signaling.
1,25-Dihydroxyvitamin D3 (1,25D) is a vitamin D hormone metabolite that activates the vitamin D receptor to have biological effects (VDR). In the presence of 1,25D, the retinoid X receptor (RXR) and vitamin D receptor (VDR) create a heterodimer that binds to vitamin D responsive elements in the area of genes directly regulated by 1,25D. To promote the classic vitamin D activities including intestinal calcium and phosphate absorption and bone and calcium homeostasis, ligand-activated VDR-RXR recruits’ coactivator or corepressor complexes to control transcription of genes encoding the relevant protein genes. Thus, vitamin D action in a particular cell is dependent on the metabolic production or delivery of sufficient concentrations of the 1,25D ligand, expression of adequate VDR and RXR coreceptor proteins, and cell-specific programming of transcriptional responses to regulate select genes that encode proteins that function in mediating the effects of vitamin D. RANKL, SPP1 (osteopontin), and BGP control bone mineral remodeling; TRPV6, CaBP9k, and claudin 2 increase intestinal calcium absorption; TRPV5, klotho, and Npt2c regulate renal calcium and phosphate reabsorption. In keratinocytes, VDR seems to act without 1,25D ligand to regulate mammalian hair cycle by regulating genes such as CASP14, S100A8, SOSTDC1, and others that influence Wnt signaling. Other low-affinity non-vitamin D VDR ligands, such lithocholic acid, docosahexaenoic acid, and curcumin, have also been identified. Chronic diseases of aging including as osteoporosis, type 2 diabetes, cardiovascular disease, and cancer may be slowed down by a combination of alternate VDR ligands and 1,25D/VDR gene expression regulation.

Citations

Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.

IJARIIE Neha Patel, and Dr. Syed Shahab Ahmad. "Bio- Chemical and Molecular Mechanisms of Vitamin D" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 4 2020 Page 2694-2700
MLA Neha Patel, and Dr. Syed Shahab Ahmad. "Bio- Chemical and Molecular Mechanisms of Vitamin D." International Journal Of Advance Research And Innovative Ideas In Education 6.4(2020) : 2694-2700.
APA Neha Patel, & Dr. Syed Shahab Ahmad. (2020). Bio- Chemical and Molecular Mechanisms of Vitamin D. International Journal Of Advance Research And Innovative Ideas In Education, 6(4), 2694-2700.
Chicago Neha Patel, and Dr. Syed Shahab Ahmad. "Bio- Chemical and Molecular Mechanisms of Vitamin D." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 4 (2020) : 2694-2700.
Oxford Neha Patel, and Dr. Syed Shahab Ahmad. 'Bio- Chemical and Molecular Mechanisms of Vitamin D', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, 2020, p. 2694-2700. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Bio__Chemical_and_Molecular_Mechanisms_of_Vitamin_D_ijariie17856.pdf (Accessed : ).
Harvard Neha Patel, and Dr. Syed Shahab Ahmad. (2020) 'Bio- Chemical and Molecular Mechanisms of Vitamin D', International Journal Of Advance Research And Innovative Ideas In Education, 6(4), pp. 2694-2700IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Bio__Chemical_and_Molecular_Mechanisms_of_Vitamin_D_ijariie17856.pdf (Accessed : )
IEEE Neha Patel, and Dr. Syed Shahab Ahmad, "Bio- Chemical and Molecular Mechanisms of Vitamin D," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, pp. 2694-2700, Jul-Aug 2020. [Online]. Available: http://ijariie.com/AdminUploadPdf/Bio__Chemical_and_Molecular_Mechanisms_of_Vitamin_D_ijariie17856.pdf [Accessed : ].
Turabian Neha Patel, and Dr. Syed Shahab Ahmad. "Bio- Chemical and Molecular Mechanisms of Vitamin D." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 4 ().
Vancouver Neha Patel, and Dr. Syed Shahab Ahmad. Bio- Chemical and Molecular Mechanisms of Vitamin D. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : ]; 6(4) : 2694-2700. Available from: http://ijariie.com/AdminUploadPdf/Bio__Chemical_and_Molecular_Mechanisms_of_Vitamin_D_ijariie17856.pdf
BibTex EndNote RefMan RefWorks

Number Of Downloads



Save in Google Drive

Similar-Paper

TitleArea of ResearchAuther NameAction
DIAGNOSIS OF VARIOUS STAGES OF DIABETIC RETINOPATHY USING A DEEP LEARNING BASED APPROACH FROM SMART PHONE BASED FUDUS IMAGESBiomedical EngineeringJeeva Prakash N Download
APPLICATIONS OF NANOMATERIALS FOR BIOMATERIALS: DEVELOPING NANOMATERIAL-ENHANCED BIOMATERIALS USING COMPUTATIONAL DOCKING OF PROTEIN-LIGAND PAIRSBiotechnologyHarsa Pravena Viswanathan Download
Assessment of the Quality of Healthcare Services at Sabrata Teaching Hospital in Libya from the Perspective of PatientsMedical Computer EngineeringAHMED AMER SALEM OUN Download
“Microalgal Biofuels for a Greener Earth: A Review"BiotechnologyMonika Saini Download
UTILIZING FUZZY EXPERT SYSTEM TO AID IN DIAGNOSING HEART DISEASES AT SABRATA HOSPITAL, LIBYAMedical Computer EngineeringHajir Mohamed Ben Amer Download
A Review on herbal monograph preparation:Tulsi (Ocimum sanctum)pharmacyMr. Amol M. Sangale Download
Investigation Of The Antidiabetic Activity Of Cnicus Benedictus L. In RatspharmacyMr. Sujeet B. Andhale Download
Regulation of Age-Related Diabetes Via Bioactive CompoundsBiotechnologyHarsa Pravena V Download
In silico safety assessment and morphological characterization of transgenic Maruca vitrata resistant cowpea (Vigna unguiculata L. Walp)Biotechnology and BioinformaticsAbraham Isah Download
A BRIEF ARTICLE OF ASTHMAPharamcyGautam Ankita Vinod Download
Formulation And Evaluation Of Herbal Gel For The Treatment Of Anti Microbial PotencypharmacyMr. Ganesh B. Dhaygude Download
ANTIDANDRUFF HAIR HERBAL GEL FOR DANDRUFF FREE HAIRSpharmacyMr. Hemant Vikas Dhadapa Download
Formulation and evaluation of fairness creamPharmacy Kadam Vaibhav N. Download
ISOLATION AND IDENTIFICATION OF ENDOPHYTIC FUNGI FROM MEDICINAL PLANT AND ITS ANTI-OXIDANT,ANTI-MICROBIAL,ANTI-FUNGAL AND ANTI-CANCER ACTIVITYBIOTECHNOLOGYMYTHILI T J Download
FATHOM ON HUMAN ORAL MICROBIOMEmicrobiologyPavitra T Download
12