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Title: :  PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS
PaperId: :  19773
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 2 2023
DUI:    16.0415/IJARIIE-19773
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr. V.V. PaithankarVidyabharti college of Pharmacy Amravati, Maharastra
Mr. Komal ThakreVidyabharti college of Pharmacy Amravati, Maharastra
Dr. A.M. WankhedeVidyabharti college of Pharmacy Amravati, Maharastra
Mr. J.V. VyasVidyabharti college of Pharmacy Amravati, Maharastra
Mrs. Puja BadneShri Sadguru Datta Institute Of Pharmacy-[SSDIP], Nagpur

Abstract

Department of Pharmacology (M.pharm)
I send research article for publication
The current study standardizes the following models for schizophrenia-induced psychosis (Amphetamine/Dexamethasone/Apomorphine). To investigate the impact of Olanzapine alone and in combination with Plumbagin in Schizophrenia, using at least two dosages of each group and assess behavioral parameters (pharmacodynamics estimation). Using docking software, conduct pharmacokinetic experiments for bioavailability enhancement estimates and ADME studies for pharmacokinetics estimation. The objective of this study is the improvement in the bioavailability of this drug by using the agents which are the promising inhibitors of these sub enzymes of CYP namely plumbagin and piperine which ultimately may lead to an increase in bioavailability and increased in the duration of action of selected drug. In present study procurement of Drugs- Olanzapine, Dexamethasone, Plumbagin, Standardization of Models of Psychosis- Dexamethasone induced psychosis, Pharmacological Evaluation- Olanzapine alone and in combination with plumbagin by following models-Behavioural Models- Hyperactivity, Anhedonia (Splash Test), Stereotypy, Social Interaction Test are studied to enhance the bioavailability and activity of some anti- psychotic drugs. And also pharmacokinetic study for bioavailability estimation and In Silico studies for determination of ADME profiles of drugs are carried out.

Citations

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IJARIIE Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. "PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 2 2023 Page 2606-2623
MLA Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. "PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS." International Journal Of Advance Research And Innovative Ideas In Education 9.2(2023) : 2606-2623.
APA Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, & Mrs. Puja Badne. (2023). PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS. International Journal Of Advance Research And Innovative Ideas In Education, 9(2), 2606-2623.
Chicago Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. "PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 2 (2023) : 2606-2623.
Oxford Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. 'PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 2, 2023, p. 2606-2623. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/PHARMACOLOGICAL_APPROACH_OF_PLUMBAGIN__PIPERINE_FOR_IMPROVED_BIOAVAILABILITY_OF_SOME_ANTI_PSYCHOTIC_DRUGS_ijariie19773.pdf (Accessed : 04 April 2025).
Harvard Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. (2023) 'PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS', International Journal Of Advance Research And Innovative Ideas In Education, 9(2), pp. 2606-2623IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/PHARMACOLOGICAL_APPROACH_OF_PLUMBAGIN__PIPERINE_FOR_IMPROVED_BIOAVAILABILITY_OF_SOME_ANTI_PSYCHOTIC_DRUGS_ijariie19773.pdf (Accessed : 04 April 2025)
IEEE Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne, "PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 2, pp. 2606-2623, Mar-App 2023. [Online]. Available: http://ijariie.com/AdminUploadPdf/PHARMACOLOGICAL_APPROACH_OF_PLUMBAGIN__PIPERINE_FOR_IMPROVED_BIOAVAILABILITY_OF_SOME_ANTI_PSYCHOTIC_DRUGS_ijariie19773.pdf [Accessed : 04 April 2025].
Turabian Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. "PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 2 (04 April 2025).
Vancouver Dr. V.V. Paithankar, Mr. Komal Thakre, Dr. A.M. Wankhede, Mr. J.V. Vyas, and Mrs. Puja Badne. PHARMACOLOGICAL APPROACH OF PLUMBAGIN, PIPERINE FOR IMPROVED BIOAVAILABILITY OF SOME ANTI-PSYCHOTIC DRUGS. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 04 April 2025]; 9(2) : 2606-2623. Available from: http://ijariie.com/AdminUploadPdf/PHARMACOLOGICAL_APPROACH_OF_PLUMBAGIN__PIPERINE_FOR_IMPROVED_BIOAVAILABILITY_OF_SOME_ANTI_PSYCHOTIC_DRUGS_ijariie19773.pdf
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