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Title: :  EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET
PaperId: :  21690
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 5 2023
DUI:    16.0415/IJARIIE-21690
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Yin JunhaiMaster of Clinical Medicine Study Program, Faculty of Medicine, Dentistry and Health Sciences

Abstract

Clinical Medicine
mangosteen peel, dyslipidemia, ethanol, fat
Dyslipidemia is caused by the disruption of lipid metabolism due to the interaction of genetic and environmental factors. RISKEDAS data also showed that 15.9% of the population aged ≥ 15 years had a very high proportion of LDL (≥ 190 mg/dl), 22.9% had HDL levels less than 40 mg/dl, and 11.9% with very high triglyceride levels (≥ 500 mg/dl). Natural ingredients that have the potential to be an alternative are mangosteen peels. This experimental study uses a Pre-test and Post-test group-only control design approach that uses male Wistar rats as experimental animals, with as many as four male Wistar rats (Rattus norvegicus) in each treatment group—analyzed with One-Way Anova if the data were normally distributed with a follow-up test in the form of a Post Hoc Tukey HSD test to see noticeable differences between treatments. However, if the broadcast data is abnormal, the Kruskal-Wallis test is used as an alternative test. Total cholesterol in all rat treatment groups showed significant differences; this can be seen from the P value <0.05. Triglyceride levels in all treatment groups also showed substantial differences; this can be seen from P < 0.05 (P value = 0.018). The total cholesterol of rats before giving a high-fat diet in all treatment groups did not show significant differences (P value = 0.829). LDL levels also showed significant differences in all treatment groups; this can be seen from the value of P < 0.05. HDL levels also showed significant differences in all treatment groups; this can be seen from P < 0.05 (P value = 0.018). Mangosteen rind ethanol extract can significantly reduce total cholesterol, reduce triglyceride levels, reduce LDL levels, SGOT levels (Value = 0.007), and SGPT (P value < 0.05) compared to the control group. In contrast, mangosteen rind ethanol extract can significantly increase HDL levels compared to the control group (P value = 0.018).

Citations

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IJARIIE Yin Junhai. "EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 5 2023 Page 1083-1090
MLA Yin Junhai. "EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET." International Journal Of Advance Research And Innovative Ideas In Education 9.5(2023) : 1083-1090.
APA Yin Junhai. (2023). EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET. International Journal Of Advance Research And Innovative Ideas In Education, 9(5), 1083-1090.
Chicago Yin Junhai. "EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 5 (2023) : 1083-1090.
Oxford Yin Junhai. 'EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, 2023, p. 1083-1090. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/EFFECTIVENESS_OF_ETHANOL_EXTRACT_OF_MANGOSTEEN_FRUIT_PEEL__GARCINIA_MANGOSTANA_L___ON_ANTI_DYSLIPEDEMIA_EFFECTIVENESS_IN_MALE_RATS_FED_A_HIGH_FAT_DIET_ijariie21690.pdf (Accessed : 24 November 2024).
Harvard Yin Junhai. (2023) 'EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET', International Journal Of Advance Research And Innovative Ideas In Education, 9(5), pp. 1083-1090IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/EFFECTIVENESS_OF_ETHANOL_EXTRACT_OF_MANGOSTEEN_FRUIT_PEEL__GARCINIA_MANGOSTANA_L___ON_ANTI_DYSLIPEDEMIA_EFFECTIVENESS_IN_MALE_RATS_FED_A_HIGH_FAT_DIET_ijariie21690.pdf (Accessed : 24 November 2024)
IEEE Yin Junhai, "EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, pp. 1083-1090, Sep-Oct 2023. [Online]. Available: http://ijariie.com/AdminUploadPdf/EFFECTIVENESS_OF_ETHANOL_EXTRACT_OF_MANGOSTEEN_FRUIT_PEEL__GARCINIA_MANGOSTANA_L___ON_ANTI_DYSLIPEDEMIA_EFFECTIVENESS_IN_MALE_RATS_FED_A_HIGH_FAT_DIET_ijariie21690.pdf [Accessed : 24 November 2024].
Turabian Yin Junhai. "EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 5 (24 November 2024).
Vancouver Yin Junhai. EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 24 November 2024]; 9(5) : 1083-1090. Available from: http://ijariie.com/AdminUploadPdf/EFFECTIVENESS_OF_ETHANOL_EXTRACT_OF_MANGOSTEEN_FRUIT_PEEL__GARCINIA_MANGOSTANA_L___ON_ANTI_DYSLIPEDEMIA_EFFECTIVENESS_IN_MALE_RATS_FED_A_HIGH_FAT_DIET_ijariie21690.pdf
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