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Title: :  THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT
PaperId: :  22252
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 6 2023
DUI:    16.0415/IJARIIE-22252
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
CHAITANYA PAWARJAIN DEEMED-TO-BE UNIVERSITY, BANGALORE
AREES JAVAIDJAIN DEEMED-TO-BE UNIVERSITY, BANGALORE
DR. P. BHUJANGA RAOJAIN DEEMED-TO-BE UNIVERSITY, BANGALORE

Abstract

Commerce and Management
Chronic Stress, Hypothalamic-Pituitary-Adrenal Axis, Tumor Microenvironment, Immunity, Stress Management
Understanding the connection between stress and cancer is particularly important as anxiety and depression are highly prevalent in patients with cancer. Cancer diagnosis and treatment may cause symptoms that meet the full clinical criteria of post-traumatic stress disorder in up to ~20% of total cases and can lead to long-term alterations in neuroendocrine circuitries. Surgery-related stress has been shown to cause an excess release of catecholamines and prostaglandins perioperatively in patients with cancer, which can promote metastatic progression. Despite the lack of proof that stress causes cancer in humans, there is convincing epidemiological evidence that objective stressors and self-evaluated psychological distress correlate with negative cancer outcomes (progression, metastasis, recurrence, therapeutic failure and increased mortality). Adverse life circumstances in general have been closely associated with a skewing towards pro-inflammatory responses and can dampen antiviral activity in circulating leukocytes. These changes have largely been attributed to glucocorticoid-related pathways and the activation of the adrenergic system. Moreover, gene signatures indicative of the activity of the glucocorticoid, adrenergic, dopaminergic, serotoninergic and muscarinic systems have been closely correlated with unfavourable outcomes in patients with prostate cancer. The adverse effect of stress on cancer outcomes has been replicated in mouse models, allowing to establish causality and to explore the underlying mechanisms. Repeated restraint, male domination or unpredictable chronic mild stress are established procedures to induce stress in rodents . These have been shown to cause behavioural, psychological and biological changes that promote tumour development, metastatic dissemination and therapeutic failure in mice. Moreover, mice held in standard housing conditions are already stressed and alleviating stress by shifting them from the hypothermic to thermoneutral conditions or placing them in an ‘enriched’ environment can significantly reduce tumour growth.

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IJARIIE CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. "THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 6 2023 Page 1967-1975
MLA CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. "THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT." International Journal Of Advance Research And Innovative Ideas In Education 9.6(2023) : 1967-1975.
APA CHAITANYA PAWAR, AREES JAVAID, & DR. P. BHUJANGA RAO. (2023). THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT. International Journal Of Advance Research And Innovative Ideas In Education, 9(6), 1967-1975.
Chicago CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. "THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 6 (2023) : 1967-1975.
Oxford CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. 'THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 6, 2023, p. 1967-1975. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/THE_IMPACT_OF_STRESS_ON_THE_IMMUNE_SYSTEM_OF_CANCER_PATIENT_ijariie22252.pdf (Accessed : ).
Harvard CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. (2023) 'THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT', International Journal Of Advance Research And Innovative Ideas In Education, 9(6), pp. 1967-1975IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/THE_IMPACT_OF_STRESS_ON_THE_IMMUNE_SYSTEM_OF_CANCER_PATIENT_ijariie22252.pdf (Accessed : )
IEEE CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO, "THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 6, pp. 1967-1975, Nov-Dec 2023. [Online]. Available: http://ijariie.com/AdminUploadPdf/THE_IMPACT_OF_STRESS_ON_THE_IMMUNE_SYSTEM_OF_CANCER_PATIENT_ijariie22252.pdf [Accessed : ].
Turabian CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. "THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 6 ().
Vancouver CHAITANYA PAWAR, AREES JAVAID, and DR. P. BHUJANGA RAO. THE IMPACT OF STRESS ON THE IMMUNE SYSTEM OF CANCER PATIENT. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : ]; 9(6) : 1967-1975. Available from: http://ijariie.com/AdminUploadPdf/THE_IMPACT_OF_STRESS_ON_THE_IMMUNE_SYSTEM_OF_CANCER_PATIENT_ijariie22252.pdf
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