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Title: :  Repurposing of Statin as an robusting approach to treat Microbial infection
PaperId: :  25850
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 1 2025
DUI:    16.0415/IJARIIE-25850
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
MamtaShri Ram College of Pharmacy
Tarun KapoorShri Ram College of Pharmacy
Kirti KaushalShri Ram College of Pharmacy

Abstract

Pharmacy
Drug repurposing, Simvastatin, Microbial infection, Medication, HMGCoA reductase inhibitors, drug development, repurposing approaches, gram positive bacteria, gram negative bacteria, antibacterial action, clinical trials.
Drug repurposing is a cutting-edge method that can save time and money in drug development by finding novel therapeutic applications for previously accepted medications. Recently, statins, which are generally used lipid-lowering medications, have drawn interest due to their possible antibacterial potentials. The pleiotropic effects of statins, which were first created to block HMG-CoA reductase in cholesterol production, include immunomodulation and antibacterial action. According to studies, statins have antibacterial, antiviral, and antifungal potentials. They work against a variety of infections, including Candida albicans, Mycobacterium tuberculosis, and Staphylococcus aureus. It is thought that their antimicrobial effect is achieved by a variety of mechanisms, including as host immune response regulation, bacterial biofilm suppression, and membrane disruption. Additionally, statins have been demonstrated to improve the effectiveness of traditional antibiotics, indicating that combined treatment may have a synergistic impact. As antibiotic resistance are on peak, statins' potential application in antimicrobial treatment is profoundly imperative. Statins are widely accessible and have a well-established safety profile, making them a potential safer substitute for conventional antibacterial drugs. However, more clinical research is needed to identify the best dosage, effectiveness, and potential side effects while treating infectious diseases. Conclusively, using statins as antimicrobial agents is an intriguing approach to medication development. Developing new treatment approaches to treat drug-resistant illnesses might result from an understanding of their mechanisms of action and clinical application, which would eventually support international efforts to prevent antimicrobial resistance.

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IJARIIE Mamta, Tarun Kapoor, and Kirti Kaushal. "Repurposing of Statin as an robusting approach to treat Microbial infection" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 1 2025 Page 1634-1649
MLA Mamta, Tarun Kapoor, and Kirti Kaushal. "Repurposing of Statin as an robusting approach to treat Microbial infection." International Journal Of Advance Research And Innovative Ideas In Education 11.1(2025) : 1634-1649.
APA Mamta, Tarun Kapoor, & Kirti Kaushal. (2025). Repurposing of Statin as an robusting approach to treat Microbial infection. International Journal Of Advance Research And Innovative Ideas In Education, 11(1), 1634-1649.
Chicago Mamta, Tarun Kapoor, and Kirti Kaushal. "Repurposing of Statin as an robusting approach to treat Microbial infection." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 1 (2025) : 1634-1649.
Oxford Mamta, Tarun Kapoor, and Kirti Kaushal. 'Repurposing of Statin as an robusting approach to treat Microbial infection', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 1, 2025, p. 1634-1649. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Repurposing_of_Statin_as_an_robusting_approach_to_treat_Microbial_infection_ijariie25850.pdf (Accessed : ).
Harvard Mamta, Tarun Kapoor, and Kirti Kaushal. (2025) 'Repurposing of Statin as an robusting approach to treat Microbial infection', International Journal Of Advance Research And Innovative Ideas In Education, 11(1), pp. 1634-1649IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Repurposing_of_Statin_as_an_robusting_approach_to_treat_Microbial_infection_ijariie25850.pdf (Accessed : )
IEEE Mamta, Tarun Kapoor, and Kirti Kaushal, "Repurposing of Statin as an robusting approach to treat Microbial infection," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 1, pp. 1634-1649, Jan-Feb 2025. [Online]. Available: http://ijariie.com/AdminUploadPdf/Repurposing_of_Statin_as_an_robusting_approach_to_treat_Microbial_infection_ijariie25850.pdf [Accessed : ].
Turabian Mamta, Tarun Kapoor, and Kirti Kaushal. "Repurposing of Statin as an robusting approach to treat Microbial infection." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 1 ().
Vancouver Mamta, Tarun Kapoor, and Kirti Kaushal. Repurposing of Statin as an robusting approach to treat Microbial infection. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(1) : 1634-1649. Available from: http://ijariie.com/AdminUploadPdf/Repurposing_of_Statin_as_an_robusting_approach_to_treat_Microbial_infection_ijariie25850.pdf
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