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Title: :  DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY
PaperId: :  26673
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 3 2025
DUI:    16.0415/IJARIIE-26673
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mr. Saurabh Vitthal DahatondeShivajirao Pawar College of Pharmacy
Dr Abhijeet Raosaheb SheteShivajirao Pawar College of Pharmacy
Dr. Magha T. SalveShivajirao Pawar College of Pharmacy

Abstract

Pharmacy
Keywords : Rabeprazole sodium, gastro oesophageal reflux, Enteric coated tablets, Dissolution,stability
Rabeprazole sodium is a proton pump inhibitor that works by blocking the acidic pump enzyme H+ /K+ATPase, which is used to treat peptic ulcers, duodenal ulcers, and gastro-oesophageal reflux disease. Additionally, it is used to treat erosive esophagitis and Zollinger-Ellison syndrome. The goal of this research is to create enteric-coated tablets of Rabeprazole sodium that are stable and pharmaceutically equal to the original product. The goal of the current work is to prevent drug breakdown in the stomach's acidic environment. Mannitol as diluents, magnesium stearate and talc as lubricants and glidants, ethyl cellulose as a seal coating, Eudragit L-30, Plasacrylic HTP, and Instacoat EN HPMC Pthalate as an enteric coating were used to create ten different formulations of Rabeprazole core tablets. F9 outperformed the innovator in terms of drug release profile among the 10 batches of uncoated tablets. As a result, batch F9 was chosen for enteric coating and subcoating, two additional formulation stages. Following enteric coating, batches F9 were assessed for acid resistance and in vitro dissolving tests, and they were deemed to be appropriate for Rabeprazole sodium delayed release tablets when compared to innovator. For a duration of three months, stability assessments were performed at 40°C with 75% relative humidity.

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IJARIIE Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. "DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 3 2025 Page 1781-1792
MLA Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. "DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY." International Journal Of Advance Research And Innovative Ideas In Education 11.3(2025) : 1781-1792.
APA Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, & Dr. Magha T. Salve. (2025). DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY. International Journal Of Advance Research And Innovative Ideas In Education, 11(3), 1781-1792.
Chicago Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. "DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 3 (2025) : 1781-1792.
Oxford Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. 'DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 3, 2025, p. 1781-1792. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALUATION_OF_ENTARIC_COATED_RABEPARAZOLE_SODIUM_50_MG__TABLET__FOR__ENHANCE_GASTRO_RESISTANCE_AND_STABILITY_ijariie26673.pdf (Accessed : ).
Harvard Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. (2025) 'DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY', International Journal Of Advance Research And Innovative Ideas In Education, 11(3), pp. 1781-1792IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALUATION_OF_ENTARIC_COATED_RABEPARAZOLE_SODIUM_50_MG__TABLET__FOR__ENHANCE_GASTRO_RESISTANCE_AND_STABILITY_ijariie26673.pdf (Accessed : )
IEEE Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve, "DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 3, pp. 1781-1792, May-Jun 2025. [Online]. Available: http://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALUATION_OF_ENTARIC_COATED_RABEPARAZOLE_SODIUM_50_MG__TABLET__FOR__ENHANCE_GASTRO_RESISTANCE_AND_STABILITY_ijariie26673.pdf [Accessed : ].
Turabian Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. "DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 3 ().
Vancouver Mr. Saurabh Vitthal Dahatonde, Dr Abhijeet Raosaheb Shete, and Dr. Magha T. Salve. DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(3) : 1781-1792. Available from: http://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALUATION_OF_ENTARIC_COATED_RABEPARAZOLE_SODIUM_50_MG__TABLET__FOR__ENHANCE_GASTRO_RESISTANCE_AND_STABILITY_ijariie26673.pdf
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