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Title: :  FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY
PaperId: :  27460
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 5 2025
DUI:    16.0415/IJARIIE-27460
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
AshutoshDepartment of Pharmacy, IEC University, Baddi, Himachal Pradesh
Dr. Jyoti guptaDepartment of Pharmacy, IEC University, Baddi, Himachal Pradesh
Mr. hans RajDepartment of Pharmacy, IEC University, Baddi, Himachal Pradesh

Abstract

pharmacy
Mucoadhesion, Buccal drug delivery, Bioavailability, In-Vitro permeation
In present work mucoadhesive buccal film of acyclovir were prepared by using solvent casting method. Polymers like HPMC, SCMC, Eudragit RL-100 and RS-100 were used to prepared the buccal films. Acyclovir is an antiviral drug which is widely used in the treatment of Herpes simplex virus infections. It has poor bioavailability due to high hepatic first pass metabolism. Therefore, one of the promising methods to avoid high hepatic first pass metabolism by administering the drug through buccal mucosa. All the prepared mucoadhesive buccal films were analyzed for FTIR analysis for the compatibility of drug and excipients. Further, all the films evaluated for their pH, Physical properties, spreadability, folding endurance, drug content analysis and in-vitro permeation study. From all the result it was concluded that among the acyclovir loaded buccal films, the formulation F4 containing HPMC and SCMC was found to be the best formulation showing to good drug content (75.6%), highest swelling index (57.667±4.25), highest in-vitro residence time (1.46±0.016), rough surface that is helpful in the better absorption and greatest drug release (92.84%).

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IJARIIE Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. "FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 5 2025 Page 153-165
MLA Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. "FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY." International Journal Of Advance Research And Innovative Ideas In Education 11.5(2025) : 153-165.
APA Ashutosh, Dr. Jyoti gupta, & Mr. hans Raj. (2025). FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY. International Journal Of Advance Research And Innovative Ideas In Education, 11(5), 153-165.
Chicago Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. "FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 5 (2025) : 153-165.
Oxford Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. 'FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 5, 2025, p. 153-165. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/FORMULATION_AND_CHARACTERIZATION_OF_ACYCLOVIR_LOADED_BUCCAL_MUCOADHESIVE_FILM_TO_ENHANCE_BIOAVAILABILITY_ijariie27460.pdf (Accessed : ).
Harvard Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. (2025) 'FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY', International Journal Of Advance Research And Innovative Ideas In Education, 11(5), pp. 153-165IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/FORMULATION_AND_CHARACTERIZATION_OF_ACYCLOVIR_LOADED_BUCCAL_MUCOADHESIVE_FILM_TO_ENHANCE_BIOAVAILABILITY_ijariie27460.pdf (Accessed : )
IEEE Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj, "FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 5, pp. 153-165, Sep-Oct 2025. [Online]. Available: http://ijariie.com/AdminUploadPdf/FORMULATION_AND_CHARACTERIZATION_OF_ACYCLOVIR_LOADED_BUCCAL_MUCOADHESIVE_FILM_TO_ENHANCE_BIOAVAILABILITY_ijariie27460.pdf [Accessed : ].
Turabian Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. "FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 5 ().
Vancouver Ashutosh, Dr. Jyoti gupta, and Mr. hans Raj. FORMULATION AND CHARACTERIZATION OF ACYCLOVIR LOADED BUCCAL MUCOADHESIVE FILM TO ENHANCE BIOAVAILABILITY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(5) : 153-165. Available from: http://ijariie.com/AdminUploadPdf/FORMULATION_AND_CHARACTERIZATION_OF_ACYCLOVIR_LOADED_BUCCAL_MUCOADHESIVE_FILM_TO_ENHANCE_BIOAVAILABILITY_ijariie27460.pdf
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