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Title: :  A review on: Ritlecitinib
PaperId: :  28087
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 1 2026
DUI:    16.0415/IJARIIE-28087
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Rutuja shivaji KaradMatoshri college of pharmacy eklahare Nashik
Shraddha BhavsarMatoshri college of pharmacy eklahare Nashik

Abstract

Pharmaceutical Science
Alopecia aerta, ritlecitinib.
Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up to 147 million people globally. Currently, there are no treatments approved by US Food and Drug Administration (FDA) specific for AA, and there are few effective therapeutic options for widespread and persistent illness. There is an ongoing need for a treatment that demonstrates a good clinical response with a benefit-risk ratio that is suitable for long-term use, especially for patients with chronic, extensive disease. Several clinical trials and case studies that have assessed Janus kinase inhibitors have had encouraging results. Ritlecitinib, a selective JAK3/TEC kinase inhibitor has been demonstrated to inhibit the action of signaling molecules and immune cells that are responsible for hair loss in people with alopecia areata. Furthermore, several clinical trials are investigating the utility of ritlecitinib in patients with vitiligo, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. Advantages of using ritlecitinib when compared with other non-selective JAK inhibitors include avoiding JAK1/JAK2 inhibition’s clinical repercussions, which include pharmacodynamic effects such as increased cholesterol and liver enzymes, and those related to JAK2 inhibition (thrombocytopenia, anemia). Treatment with Ritlecitinib 50 mg and 30 mg daily for 24 weeks has been shown to induce hair regrowth with a significant proportion of patients reaching SALT 20 (≤20% scalp hair loss) after six months of therapy compared to placebo. Additional research is needed for long-term effects.

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IJARIIE Rutuja shivaji Karad, and Shraddha Bhavsar. "A review on: Ritlecitinib" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 1 2026 Page 1170-1176
MLA Rutuja shivaji Karad, and Shraddha Bhavsar. "A review on: Ritlecitinib." International Journal Of Advance Research And Innovative Ideas In Education 12.1(2026) : 1170-1176.
APA Rutuja shivaji Karad, & Shraddha Bhavsar. (2026). A review on: Ritlecitinib. International Journal Of Advance Research And Innovative Ideas In Education, 12(1), 1170-1176.
Chicago Rutuja shivaji Karad, and Shraddha Bhavsar. "A review on: Ritlecitinib." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 1 (2026) : 1170-1176.
Oxford Rutuja shivaji Karad, and Shraddha Bhavsar. 'A review on: Ritlecitinib', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, 2026, p. 1170-1176. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/A_review_on__Ritlecitinib_ijariie28087.pdf (Accessed : ).
Harvard Rutuja shivaji Karad, and Shraddha Bhavsar. (2026) 'A review on: Ritlecitinib', International Journal Of Advance Research And Innovative Ideas In Education, 12(1), pp. 1170-1176IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/A_review_on__Ritlecitinib_ijariie28087.pdf (Accessed : )
IEEE Rutuja shivaji Karad, and Shraddha Bhavsar, "A review on: Ritlecitinib," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, pp. 1170-1176, Jan-Feb 2026. [Online]. Available: http://ijariie.com/AdminUploadPdf/A_review_on__Ritlecitinib_ijariie28087.pdf [Accessed : ].
Turabian Rutuja shivaji Karad, and Shraddha Bhavsar. "A review on: Ritlecitinib." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 1 ().
Vancouver Rutuja shivaji Karad, and Shraddha Bhavsar. A review on: Ritlecitinib. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : ]; 12(1) : 1170-1176. Available from: http://ijariie.com/AdminUploadPdf/A_review_on__Ritlecitinib_ijariie28087.pdf
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