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Title: :  Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study
PaperId: :  28092
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 1 2026
DUI:    16.0415/IJARIIE-28092
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mehta AnilXinjiang Medical University First Affiliated Hospital
Zahid KhanXinjiang Medical University First Affiliated Hospital
Zaib Un NishaXinjiang Medical University First Affiliated Hospital
Wang Zhi Mei Xinjiang Medical University First Affiliated Hospital

Abstract

Medical Science
Preterm birth; pulmonary regurgitation; cardiovascular dysfunction; ejection fraction; composite risk score; China; pregnancy
Background: Maternal cardiovascular dysfunction is increasingly recognized as a contributor to preterm birth, yet specific determinants—particularly pulmonary regurgitation (PR) and composite cardiovascular risk scores—remain inadequately characterized, especially in Asian populations. Objective: To identify associations between cardiovascular parameters and preterm delivery, evaluate the performance of a novel Composite Cardiovascular Dysfunction Score (CCDS), and examine independent contributions of hemodynamic and metabolic factors. Methods: This retrospective cohort study included pregnant women referred for cardiovascular assessment at a tertiary center in China. Comprehensive echocardiography, serum BNP, and hemodynamic measurements were obtained at referral. A cumulative valvular burden score (0–4) and CCDS (integrating BNP, ejection fraction, and valvular disease) were constructed. Multivariable logistic regression and ROC analyses were performed. Results: Among 71 women (49 preterm, 22 term), pulmonary regurgitation was strongly associated with preterm delivery (OR 5.81; 95% CI 1.21–27.78; p=0.022). Preterm delivery was also associated with significantly lower mean ejection fraction (56.8% vs. 61.2%; mean difference –4.4%; p=0.021). Trends toward higher mean arterial pressure (p=0.061), elevated systemic vascular resistance (p=0.062), and obesity (p=0.076) were observed. The CCDS demonstrated modest discriminatory ability (AUC 0.659; 95% CI 0.525–0.793); a score ≥7.0 yielded 67.3% sensitivity and 78.6% PPV. All seven women in the very high-risk category (9–10 points) delivered preterm (p=0.077). Each 1-point CCDS increase was associated with 28–33% higher odds of preterm delivery across multivariable models. Conclusion: Pulmonary regurgitation is a novel, independent risk factor for preterm delivery, challenging the conventional classification of regurgitant lesions as uniformly low-risk in pregnancy. Subtle systolic dysfunction and integrated cardiovascular burden contribute to preterm birth risk. These findings support comprehensive cardiovascular phenotyping in at-risk pregnancies and provide the first evidence from a Chinese cohort.

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IJARIIE Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . "Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 1 2026 Page 1177-1191
MLA Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . "Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study." International Journal Of Advance Research And Innovative Ideas In Education 12.1(2026) : 1177-1191.
APA Mehta Anil, Zahid Khan, Zaib Un Nisha, & Wang Zhi Mei . (2026). Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study. International Journal Of Advance Research And Innovative Ideas In Education, 12(1), 1177-1191.
Chicago Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . "Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 1 (2026) : 1177-1191.
Oxford Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . 'Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, 2026, p. 1177-1191. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Cardiovascular_Determinants_Of_Preterm_Birth__A_Chinese_Cohort_Study_ijariie28092.pdf (Accessed : ).
Harvard Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . (2026) 'Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study', International Journal Of Advance Research And Innovative Ideas In Education, 12(1), pp. 1177-1191IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Cardiovascular_Determinants_Of_Preterm_Birth__A_Chinese_Cohort_Study_ijariie28092.pdf (Accessed : )
IEEE Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei , "Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, pp. 1177-1191, Jan-Feb 2026. [Online]. Available: http://ijariie.com/AdminUploadPdf/Cardiovascular_Determinants_Of_Preterm_Birth__A_Chinese_Cohort_Study_ijariie28092.pdf [Accessed : ].
Turabian Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . "Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 1 ().
Vancouver Mehta Anil, Zahid Khan, Zaib Un Nisha, and Wang Zhi Mei . Cardiovascular Determinants Of Preterm Birth: A Chinese Cohort Study. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : ]; 12(1) : 1177-1191. Available from: http://ijariie.com/AdminUploadPdf/Cardiovascular_Determinants_Of_Preterm_Birth__A_Chinese_Cohort_Study_ijariie28092.pdf
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