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Title: :  Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania
PaperId: :  6233
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 3 Issue 4 2017
DUI:    16.0415/IJARIIE-6233
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Sonali GangwarCenter for Biological Engineering, Shobhit University, Gangoh, Saharanpur, U.P, India
Durg Vijay RaiCenter for Biological Engineering Shobhit University, Gangoh, Saharanpur, U.P. India
Maya Datt JoshiDepartment of Biotechnology, Shobhit University, Meerut,U.P, India

Abstract

Biological Engineering
Leishmaniasis, Drug resistance, Antileishmanial drugs
Leishmaniasis is a well known fatal disease that is caused by the protozoan species belonging to the genus Leishmania. The causative organism is transmitted through female sandflies. It is considered as a neglected tropical disease and targeted for the worldwide elimination by the World Health Organization. It is the major cause of significant morbidity and mortality in several countries of the world. Leishmania parasites cause a wide spectrum of human and animal infections ranging from the life threatening visceral disease to the disfiguring mucosal and cutaneous forms of the disease. Currently, the control of the disease totally relies on chemotherapy, as the vaccine is still under the process of development. Organic pentavalentantimonials [Sb (V)] have been the first-line drugs for the treatment of Leishmaniasis for the last seven decades. Alternatively, Amphotericin B, pentamidine and miltefosine can be used for the treatment of leishmaniasis. However, these drugs have serious limitations, such as high cost, toxicity and resistance has emerged as a major problem.Therefore, the development of new, effective antileishmanial drugs is an urgent need. The new drugs are required in an affordable price in order to control leishmaniasis worldwide. The aim of this article is to review the status of existing and emerging chemotherapy for the prevention and treatment of leishmaniasis and also focuses on the various mechanisms which may lead to antimony resistance in leishmaniasis.

Citations

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IJARIIE Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. "Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania" International Journal Of Advance Research And Innovative Ideas In Education Volume 3 Issue 4 2017 Page 1914-1924
MLA Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. "Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania." International Journal Of Advance Research And Innovative Ideas In Education 3.4(2017) : 1914-1924.
APA Sonali Gangwar, Durg Vijay Rai, & Maya Datt Joshi. (2017). Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania. International Journal Of Advance Research And Innovative Ideas In Education, 3(4), 1914-1924.
Chicago Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. "Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania." International Journal Of Advance Research And Innovative Ideas In Education 3, no. 4 (2017) : 1914-1924.
Oxford Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. 'Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania', International Journal Of Advance Research And Innovative Ideas In Education, vol. 3, no. 4, 2017, p. 1914-1924. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Current_Status_of_Existing_and_Emerging_Chemotherapy_and_Drug_Resistance_Mechanisms_in_Leishmania_ijariie6233.pdf (Accessed : 01 December 2018).
Harvard Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. (2017) 'Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania', International Journal Of Advance Research And Innovative Ideas In Education, 3(4), pp. 1914-1924IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Current_Status_of_Existing_and_Emerging_Chemotherapy_and_Drug_Resistance_Mechanisms_in_Leishmania_ijariie6233.pdf (Accessed : 01 December 2018)
IEEE Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi, "Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania," International Journal Of Advance Research And Innovative Ideas In Education, vol. 3, no. 4, pp. 1914-1924, Jul-Aug 2017. [Online]. Available: http://ijariie.com/AdminUploadPdf/Current_Status_of_Existing_and_Emerging_Chemotherapy_and_Drug_Resistance_Mechanisms_in_Leishmania_ijariie6233.pdf [Accessed : 01 December 2018].
Turabian Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. "Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 3 number 4 (01 December 2018).
Vancouver Sonali Gangwar, Durg Vijay Rai, and Maya Datt Joshi. Current Status of Existing and Emerging Chemotherapy and Drug Resistance Mechanisms in Leishmania. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2017 [Cited : 01 December 2018]; 3(4) : 1914-1924. Available from: http://ijariie.com/AdminUploadPdf/Current_Status_of_Existing_and_Emerging_Chemotherapy_and_Drug_Resistance_Mechanisms_in_Leishmania_ijariie6233.pdf
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