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Title: :  FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY
PaperId: :  7115
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 3 Issue 6 2017
DUI:    16.0415/IJARIIE-7115
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Madhusudan BokkaUNIVERSITY COLLEGE OF TECHNOLOGY , OSMANIA UNIVERSITY HYDERABAD
NARESH NOMULAUNIVERSITY COLLEGE OF TECHNOLOGY , OSMANIA UNIVERSITY HYDERABAD

Abstract

Pharmaceutical sciences
Complexation, FTIR, Beta cyclodextrin, Chitosan, Gastric ulcers, Kollicoat, Lansoprazole, Photostability.
Enteric coated sustain release Lansoprazole tablets which are proton pump inhibitors in action, are widely used in the treatment of gastric ulcers. The aim of the present study is to improve photostability of Lansoprazole. Enteric Coated sustain release tablets of Lansoprazole were formulates by using enteric polymers like Kollicoat MAE 30DP, and Eudragit L 100. Primary characterization of the drug was done by performing the melting point, identification test by Fourier Transform Infrared Spectroscopy, solubility and assay. To understand the compatibility of the drug with excipients, drug-excipient studies were carried out using Infrared spectroscopy. Using complexation technique different ratios of the drug were complexed with cyclodextrin to improve photostability. The stability test results indicated that the inclusion complex was more stable than raw Lansoprazole in the light. It was observed that inclusion complex of Lansoprazole showed increased the solubility by about 4.5 times. There were no significant differences between 30 min, 6 h and 24 h for either raw material or inclusion complex. Among the four polymers chitosan, xanthum gum, locust bean gum, and guar gum as polymers, chitosan was chosen for further coating process. Physico-chemical and in-vitro drug release studies were performed to all the formulations. F4c formulation was found to be best formulation which showed better resistance in 0.1N HCL, sustained well and with in-vitro release of 97.83± 0.39% release in 12hrs.

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IJARIIE Madhusudan Bokka, and NARESH NOMULA. "FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY" International Journal Of Advance Research And Innovative Ideas In Education Volume 3 Issue 6 2017 Page 1261-1270
MLA Madhusudan Bokka, and NARESH NOMULA. "FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY." International Journal Of Advance Research And Innovative Ideas In Education 3.6(2017) : 1261-1270.
APA Madhusudan Bokka, & NARESH NOMULA. (2017). FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY. International Journal Of Advance Research And Innovative Ideas In Education, 3(6), 1261-1270.
Chicago Madhusudan Bokka, and NARESH NOMULA. "FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY." International Journal Of Advance Research And Innovative Ideas In Education 3, no. 6 (2017) : 1261-1270.
Oxford Madhusudan Bokka, and NARESH NOMULA. 'FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 3, no. 6, 2017, p. 1261-1270. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ENTERIC_COATED_SUSTAIN_RELEASE_TABLETS_OF_LANSOPRAZOLE_IN_A_β_CYCLODEXTRIN_COMPLEX_TO_IMPROVE_THE_PHOTOSTABILITY_ijariie7115.pdf (Accessed : ).
Harvard Madhusudan Bokka, and NARESH NOMULA. (2017) 'FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY', International Journal Of Advance Research And Innovative Ideas In Education, 3(6), pp. 1261-1270IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ENTERIC_COATED_SUSTAIN_RELEASE_TABLETS_OF_LANSOPRAZOLE_IN_A_β_CYCLODEXTRIN_COMPLEX_TO_IMPROVE_THE_PHOTOSTABILITY_ijariie7115.pdf (Accessed : )
IEEE Madhusudan Bokka, and NARESH NOMULA, "FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 3, no. 6, pp. 1261-1270, Nov-Dec 2017. [Online]. Available: http://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ENTERIC_COATED_SUSTAIN_RELEASE_TABLETS_OF_LANSOPRAZOLE_IN_A_β_CYCLODEXTRIN_COMPLEX_TO_IMPROVE_THE_PHOTOSTABILITY_ijariie7115.pdf [Accessed : ].
Turabian Madhusudan Bokka, and NARESH NOMULA. "FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 3 number 6 ().
Vancouver Madhusudan Bokka, and NARESH NOMULA. FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β-CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2017 [Cited : ]; 3(6) : 1261-1270. Available from: http://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ENTERIC_COATED_SUSTAIN_RELEASE_TABLETS_OF_LANSOPRAZOLE_IN_A_β_CYCLODEXTRIN_COMPLEX_TO_IMPROVE_THE_PHOTOSTABILITY_ijariie7115.pdf
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