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Title: :  INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES
PaperId: :  9013
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 4 Issue 4 2018
DUI:    16.0415/IJARIIE-9013
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
VISHNU BALAMURUGANDr.N.G.P arts and science college, coimbatore, tamilnadu, india

Abstract

Bionanotechnology
Bionanotechnology, niosomes, liposomes, drug delivery, targeted drug delivery, controlled drug delivery.
Niosomes and liposomes are noble drug delivery systems used for the targeted drug delivery in this research, the lipid Nanovesicles like Niosomes and liposomes were synthesised from cholesterol, a Phosphatidylcholines. The L-Tyrosine, an amino acid is taken as a model drug which has been used as a drug for entrapment and release at the targeted sites. The entrapment efficiency of the drug in their respective Nano vesicles is calculated. The release was done invitro by membrane dialysis method. The release was estimated and graphs were constructed. The release of the drugs from the different Nanovesicles was done at different pH to optimise the release and to target the site of release as an application. The optimisation is done by changing the factors like chemicals ratio, changing the pH to identify the areas with highest and lowest release. As a result the water soluble drug, L-tyrosine shows better entrapment in both Niosomes and liposomes but the entrapment efficiency was highest in the Niosomes of the chemical composition 1:1 i.e., Cholesterol and span-60 respectively. The drug release was much more effective again in niosomes than in other Nanovesicles as the drug release was constantly increasing but the 2:1 ratio sample of Niosomes shown controlled release. The pH optimisation shows that the drug release was maximum at alkaline pH of 11 and next in the acidic pH of 3. The release was least at the alkaline pH of 9. In overall comparison, Niosomes vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes in the targeted drug delivery systems and are superior to liposomes in this case.

Citations

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IJARIIE VISHNU BALAMURUGAN. "INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES" International Journal Of Advance Research And Innovative Ideas In Education Volume 4 Issue 4 2018 Page 1078-1085
MLA VISHNU BALAMURUGAN. "INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES." International Journal Of Advance Research And Innovative Ideas In Education 4.4(2018) : 1078-1085.
APA VISHNU BALAMURUGAN. (2018). INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES. International Journal Of Advance Research And Innovative Ideas In Education, 4(4), 1078-1085.
Chicago VISHNU BALAMURUGAN. "INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES." International Journal Of Advance Research And Innovative Ideas In Education 4, no. 4 (2018) : 1078-1085.
Oxford VISHNU BALAMURUGAN. 'INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES', International Journal Of Advance Research And Innovative Ideas In Education, vol. 4, no. 4, 2018, p. 1078-1085. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/INVITRO_COMPARISON_OF_CONTROLLED_AND_TARGETED_DRUG_DELIVERY_USING_NIOSOMES_AND_LIPOSOMES_ijariie9013.pdf (Accessed : 20 August 2018).
Harvard VISHNU BALAMURUGAN. (2018) 'INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES', International Journal Of Advance Research And Innovative Ideas In Education, 4(4), pp. 1078-1085IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/INVITRO_COMPARISON_OF_CONTROLLED_AND_TARGETED_DRUG_DELIVERY_USING_NIOSOMES_AND_LIPOSOMES_ijariie9013.pdf (Accessed : 20 August 2018)
IEEE VISHNU BALAMURUGAN, "INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES," International Journal Of Advance Research And Innovative Ideas In Education, vol. 4, no. 4, pp. 1078-1085, Jul-Aug 2018. [Online]. Available: https://ijariie.com/AdminUploadPdf/INVITRO_COMPARISON_OF_CONTROLLED_AND_TARGETED_DRUG_DELIVERY_USING_NIOSOMES_AND_LIPOSOMES_ijariie9013.pdf [Accessed : 20 August 2018].
Turabian VISHNU BALAMURUGAN. "INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 4 number 4 (20 August 2018).
Vancouver VISHNU BALAMURUGAN. INVITRO COMPARISON OF CONTROLLED AND TARGETED DRUG DELIVERY USING NIOSOMES AND LIPOSOMES. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2018 [Cited : 20 August 2018]; 4(4) : 1078-1085. Available from: https://ijariie.com/AdminUploadPdf/INVITRO_COMPARISON_OF_CONTROLLED_AND_TARGETED_DRUG_DELIVERY_USING_NIOSOMES_AND_LIPOSOMES_ijariie9013.pdf
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