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Title: :  FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM
PaperId: :  12452
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 4 2020
DUI:    16.0415/IJARIIE-12452
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Yerikala RameshAssociate Professor, Ratnam Institute of Pharmacy, Pidathapolur (V), Muthukur (M), Nellore-524346, Andhra Pradesh, India.
Goparaju Suryanarayana Murthy Professor, CMR Technical Campus Autonomous Hyderabad, Telangana, India
Vuthipalli SireeshaAssistant Professor, Ratnam Institute of Pharmacy, Pidathapolur (V), Muthukur (M), Nellore-524346, Andhra Pradesh, India.

Abstract

Pharmacy
Diphenhydramine, Medicated chewing gums, local disinfectant, mouth diseases.
The release of a drug from chewing gum is dependent upon its water solubility. Water soluble substances are released rapidly and completely from chewing gum and methods are available which retard their release from chewing gum to provide an extended release profile. An attempt has been made to formulate new chewing gum device for Diphenhydramine in the form of tablet. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Diphenhydramine for by passing the hepatic first pass effect. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. Better consistency of formulation and faster release of drug in saliva was obtained with glycerol P (IV), and Castor oil F (II) but castor oil shows optimum result against glycerol combination, which is formulation II. Urinary excretion profile showed that within the short span of time 1.5 h drug was excreted. Buccal absorption test showed that 80% of drug absorbed within 10 min when available to the buccal mucosa at pH 5.5.

Citations

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IJARIIE Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. "FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 4 2020 Page 1210-1215
MLA Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. "FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM." International Journal Of Advance Research And Innovative Ideas In Education 6.4(2020) : 1210-1215.
APA Yerikala Ramesh, Goparaju Suryanarayana Murthy , & Vuthipalli Sireesha. (2020). FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM. International Journal Of Advance Research And Innovative Ideas In Education, 6(4), 1210-1215.
Chicago Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. "FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 4 (2020) : 1210-1215.
Oxford Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. 'FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, 2020, p. 1210-1215. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_DIPHENHYDRAMINE_MEDICATED_CHEWING_GUM_ijariie12452.pdf (Accessed : 16 June 2024).
Harvard Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. (2020) 'FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM', International Journal Of Advance Research And Innovative Ideas In Education, 6(4), pp. 1210-1215IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_DIPHENHYDRAMINE_MEDICATED_CHEWING_GUM_ijariie12452.pdf (Accessed : 16 June 2024)
IEEE Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha, "FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, pp. 1210-1215, Jul-Aug 2020. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_DIPHENHYDRAMINE_MEDICATED_CHEWING_GUM_ijariie12452.pdf [Accessed : 16 June 2024].
Turabian Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. "FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 4 (16 June 2024).
Vancouver Yerikala Ramesh, Goparaju Suryanarayana Murthy , and Vuthipalli Sireesha. FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : 16 June 2024]; 6(4) : 1210-1215. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_DIPHENHYDRAMINE_MEDICATED_CHEWING_GUM_ijariie12452.pdf
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