Call for Papers:Vol.11 Issue.3

Submission
Last date		 28-Jun-2025
Acceptance Status In One Day
Paper Publish In Two Days
Submit ManuScript

News & Updates

Submit Article

Dear Authors, Article publish in our journal for Volume-11,Issue-3. For article submission on below link: Submit Manuscript


Join As Board

Dear Reviewer, You can join our Reviewer team without given any charges in our journal. Submit Details on below link: Join As Board


Paper Publication Charges

IJARIIE APP
Download Android App

For Authors

Archives

IJARIIE Board

Downloads

Android App

Download IJARIIE APP

Authors

Title: :  Design and Invitro Evaluation of Transdermal patches of Tacrine
PaperId: :  12630
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 5 2020
DUI:    16.0415/IJARIIE-12630
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Tabassum SKKGR Institute of Technology and Management
Dr K RameshKGR Institute of Technology and Management
Dr.GampaVijayKumarKGR Institute of Technology and Management

Abstract

pharmacy
Tacrine , xanthan gum, chitosan and HPMC K100M, Transdermal patches
Tacrine is a centrally acting acetylcholinesterase inhibitor and indirect cholinergic agonist (parasympathomimetic). It was the first centrally acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. It also acts as a histamine N-methyltransferase inhibitor.In present study transdermal drug delivery of Tacrine was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Oral drug delivery system has various drawbacks like poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohibitive and inconvenient. Matrix type of transdermal patches was developed by using xanthan gum, chitosan and HPMC K100M polymers. Transdermal patches were prepared by employing solvent casting method. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F9, and all the formulations were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content and Swelling study and all the results were found to be with in the pharmacopeial limits, invitro drug release studies by using dialysis membrane. Among all the 9 formulations F5 formulation which contain Chitosan 150 mg had shown 97.52% cumulative drug release with in 12 hours.

Citations

Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.

IJARIIE Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. "Design and Invitro Evaluation of Transdermal patches of Tacrine" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 5 2020 Page 64-72
MLA Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. "Design and Invitro Evaluation of Transdermal patches of Tacrine." International Journal Of Advance Research And Innovative Ideas In Education 6.5(2020) : 64-72.
APA Tabassum SK, Dr K Ramesh, & Dr.GampaVijayKumar. (2020). Design and Invitro Evaluation of Transdermal patches of Tacrine. International Journal Of Advance Research And Innovative Ideas In Education, 6(5), 64-72.
Chicago Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. "Design and Invitro Evaluation of Transdermal patches of Tacrine." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 5 (2020) : 64-72.
Oxford Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. 'Design and Invitro Evaluation of Transdermal patches of Tacrine', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 5, 2020, p. 64-72. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Design_and_Invitro_Evaluation_of_Transdermal_patches_of_Tacrine_ijariie12630.pdf (Accessed : 01 September 2020).
Harvard Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. (2020) 'Design and Invitro Evaluation of Transdermal patches of Tacrine', International Journal Of Advance Research And Innovative Ideas In Education, 6(5), pp. 64-72IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Design_and_Invitro_Evaluation_of_Transdermal_patches_of_Tacrine_ijariie12630.pdf (Accessed : 01 September 2020)
IEEE Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar, "Design and Invitro Evaluation of Transdermal patches of Tacrine," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 5, pp. 64-72, Sep-Oct 2020. [Online]. Available: https://ijariie.com/AdminUploadPdf/Design_and_Invitro_Evaluation_of_Transdermal_patches_of_Tacrine_ijariie12630.pdf [Accessed : 01 September 2020].
Turabian Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. "Design and Invitro Evaluation of Transdermal patches of Tacrine." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 5 (01 September 2020).
Vancouver Tabassum SK, Dr K Ramesh, and Dr.GampaVijayKumar. Design and Invitro Evaluation of Transdermal patches of Tacrine. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : 01 September 2020]; 6(5) : 64-72. Available from: https://ijariie.com/AdminUploadPdf/Design_and_Invitro_Evaluation_of_Transdermal_patches_of_Tacrine_ijariie12630.pdf
BibTex EndNote RefMan RefWorks

Number Of Downloads


Last download on 9/1/2020 8:46:55 AM

Save in Google Drive

Similar-Paper

TitleArea of ResearchAuther NameAction
Development of Modern Granular Churna Dosage Form: A Fusion of Classical Ayurveda and Pharmaceutics.Pharmaceutical ScienceMiss. Sarla Y. Gaikwad Download
Harnessing Medicinal Plants for Neglected Diseases: Advances in Identification, Mechanisms, Development, and IntegrationPHARMACYMr Ritik B Gogate Download
Formulation and Evaluation of Antiulcer Syruppharmacy Ms. Mayuri Sanjay Raut Download
Bioactive Bandage from SHIVAN PLANT (Gambhari): A Natural Alternative for Wound HealingPharmacy Komal R. Shelke Download
Exploring the role of artificial intelligence in mordern healthcare.PharmacyPranali Gajanan Ravekar Download
Nanotechnology in Drug DeliveryM . Pharm Ms. Pranjali V. Shandilya Download
Integrative Approaches for Neurodegenerative Disease Management: The Role of Herbal Medicines and Lifestyle ModificationsMaster Of PharmacyMs. Kartika A. Gawande Download
Nano Materials- Based Sensors For Throat Viral DetectionM. PHARMAnjali M. Sanap Download
REVIEW ON A ORAL FILM FOR THE TREAMENT OF MIGRAINEPharmacySohan S Thipe Download
FORCED DEGRADATION STUDY:- A RECENT APPROACH FOR STRESS TESTING OF DRUG SUBSTANCE AND DRUG PRODUCTSPharmacy Shraddha D Muneshwar Download
NANOTECHNOLOGY IN PARENTERAL DRUG DELIVERY: OPPORTUNITIES AND FUTURE PERSPECTIVES REVIEWPHARMACYMs. Sharayu P. Jadhav Download
Artificial Intelligence in Pharmacovigilance: Transforming drug safety & adverse event monitoringPharmacyAditi Ashutosh Mhasatkar Download
OVERVIEW ON HERBAL NANOSPONGE NOVEL DRUG DELIVERY SYSTEM.Master of Pharmacy (Quality Assurance)Ganesh Bandu Sabane Download
Herbal Extract-Based Aquasomal Formulations: A New Avenue in Antifungal TreatmentMaster of pharmacy (Quality Assurance)ROHINI SANJAY SONAR Download
Chronic Liver Disease: New Targets and MechanismsPharmacyEmmanuela John Sima Download
12