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Title: :  Formulation and Characterization of Antifungal Gel containing Fluconazole
PaperId: :  12634
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 5 2020
DUI:    16.0415/IJARIIE-12634
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Rakesh Kumar Nishad Kailash Institute of Pharmacy and Management Gorakhpur.
Mr. Amit Kumar Shukla Kailash Institute of Pharmacy and Management Gorakhpur.
J.N. Mishra DirectorKailash Institute of Pharmacy and Management Gorakhpur.

Abstract

Pharmacy
Fluconazole, Fungal infection, Polymer ratio, Topical gel.
Fluconazole is used for the treatment of local and systemic fungal infection as is a triazole derivative. The oral use of fluconazole produces several side effects hence it is not much recommended frequently. Fluconazole topical gel preparation are yet not available Commercially in the market, thus this formulation reduce the dose of drug and to avoid the side effects like liver damage and kidney damage provide better patient compliance. The gel was formulated by changing the polymer ratio. There no interaction between the drug and excipients and purity of drug confirmed by FT-IR study. drug content, pH determination, viscosity measurement, in vitro diffusion, antifungal activity and skin irritation all the factors were evaluated for gel formulations. The amount of drug diffused from formulation F1 was 97.857 ± 0.977 in4 1/2 h which was higher among all the gel formulation best fitted to Higuchi model. F1 formulation did not show any skin irritation as the viscosity of the F1 formulation was within the limits. It was found to be Gel formulation F1 stable at 30 ±2°C and 65± 5 RH. was not stable at 40 ± 2°C and 75 ± 5 RH and %CDR was decreased. Safe and efficient delivery of drug to skin application was found to be much beneficial in limiting the drug to desired site of action in the skin and reduced side effects associated with ordinary treatment.

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IJARIIE Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. "Formulation and Characterization of Antifungal Gel containing Fluconazole" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 5 2020 Page 129-143
MLA Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. "Formulation and Characterization of Antifungal Gel containing Fluconazole." International Journal Of Advance Research And Innovative Ideas In Education 6.5(2020) : 129-143.
APA Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , & J.N. Mishra Director. (2020). Formulation and Characterization of Antifungal Gel containing Fluconazole. International Journal Of Advance Research And Innovative Ideas In Education, 6(5), 129-143.
Chicago Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. "Formulation and Characterization of Antifungal Gel containing Fluconazole." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 5 (2020) : 129-143.
Oxford Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. 'Formulation and Characterization of Antifungal Gel containing Fluconazole', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 5, 2020, p. 129-143. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Formulation_and_Characterization_of_Antifungal_Gel_containing_Fluconazole_ijariie12634.pdf (Accessed : 02 September 2020).
Harvard Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. (2020) 'Formulation and Characterization of Antifungal Gel containing Fluconazole', International Journal Of Advance Research And Innovative Ideas In Education, 6(5), pp. 129-143IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Formulation_and_Characterization_of_Antifungal_Gel_containing_Fluconazole_ijariie12634.pdf (Accessed : 02 September 2020)
IEEE Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director, "Formulation and Characterization of Antifungal Gel containing Fluconazole," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 5, pp. 129-143, Sep-Oct 2020. [Online]. Available: https://ijariie.com/AdminUploadPdf/Formulation_and_Characterization_of_Antifungal_Gel_containing_Fluconazole_ijariie12634.pdf [Accessed : 02 September 2020].
Turabian Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. "Formulation and Characterization of Antifungal Gel containing Fluconazole." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 5 (02 September 2020).
Vancouver Rakesh Kumar Nishad , Mr. Amit Kumar Shukla , and J.N. Mishra Director. Formulation and Characterization of Antifungal Gel containing Fluconazole. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : 02 September 2020]; 6(5) : 129-143. Available from: https://ijariie.com/AdminUploadPdf/Formulation_and_Characterization_of_Antifungal_Gel_containing_Fluconazole_ijariie12634.pdf
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