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Title: :  FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY
PaperId: :  14084
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 7 Issue 2 2021
DUI:    16.0415/IJARIIE-14084
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Bharatia Vaibhavi PrashantSmt. BNB Swaminarayan Pharmacy College,Salvav,Vapi,Gujarat,India
Mr. Ajay TaleleSmt. BNB Swaminarayan Pharmacy College,Salvav,Vapi,Gujarat,India
Dr. Anuradha P. PrajapatiSmt. BNB Swaminarayan Pharmacy College,Salvav,Vapi,Gujarat,India
Dr. Sachin B. NarkhedeSmt. BNB Swaminarayan Pharmacy College,Salvav,Vapi,Gujarat,India

Abstract

Pharmaceutics
Eslicarbamazepine acetate, nose-to-brain, Nanosuspensions Zeta Potential, drug content, % Entrapment Efficiency and Invitro drug release
Epilepsy is a major neurological disorder affecting people of all age groups; around 50 million people worldwide are suffering from it. A combination of nanosuspension along with a nose-to-brain approach can help in promoting the treatment efficacy by site specific delivery. Eslicarbamazepine acetate (ESL) is a novel drug with dual mechanism of action i.e voltage-gated sodium channel and t-type calcium channel blocker with anticonvulsant activity. It is a prodrug, which is the drug entity responsible for the pharmacological effect with high potency and efficient safety as well as efficacy. Nanosuspensions have emerged as an attractive and promising approach to improve stability and bioavailability of poorly soluble drugs of size below 1μm, which is prepared by media milling method. The current research efforts are being directed for extending their applications in site-specific (Nasal) drug delivery system. Nanosuspensions generally have the ability to deliver the drug to the brain through olfactory and trigeminal nerves pathways circumventing the blood brain barrier. Nasal drug delivery has received a great deal of attention as a convenient, reliable and promising method for the systemic administration of drugs. The prepared formulations were then evaluated for particle size distribution (PDI), Zeta Potential, drug content, % Entrapment Efficiency and Invitro drug release

Citations

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IJARIIE Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. "FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY" International Journal Of Advance Research And Innovative Ideas In Education Volume 7 Issue 2 2021 Page 1469-1482
MLA Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. "FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY." International Journal Of Advance Research And Innovative Ideas In Education 7.2(2021) : 1469-1482.
APA Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, & Dr. Sachin B. Narkhede. (2021). FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY. International Journal Of Advance Research And Innovative Ideas In Education, 7(2), 1469-1482.
Chicago Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. "FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY." International Journal Of Advance Research And Innovative Ideas In Education 7, no. 2 (2021) : 1469-1482.
Oxford Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. 'FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 2, 2021, p. 1469-1482. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_DEVELOPMENT_AND_EVALUATION_OF_BRAIN_TARGETED_ESLICARBAMAZEPINE_ACETATE_NANOSUSPENSION_FOR_EPILEPSY_ijariie14084.pdf (Accessed : ).
Harvard Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. (2021) 'FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY', International Journal Of Advance Research And Innovative Ideas In Education, 7(2), pp. 1469-1482IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_DEVELOPMENT_AND_EVALUATION_OF_BRAIN_TARGETED_ESLICARBAMAZEPINE_ACETATE_NANOSUSPENSION_FOR_EPILEPSY_ijariie14084.pdf (Accessed : )
IEEE Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede, "FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 2, pp. 1469-1482, Mar-App 2021. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_DEVELOPMENT_AND_EVALUATION_OF_BRAIN_TARGETED_ESLICARBAMAZEPINE_ACETATE_NANOSUSPENSION_FOR_EPILEPSY_ijariie14084.pdf [Accessed : ].
Turabian Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. "FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 7 number 2 ().
Vancouver Bharatia Vaibhavi Prashant, Mr. Ajay Talele, Dr. Anuradha P. Prajapati, and Dr. Sachin B. Narkhede. FORMULATION DEVELOPMENT AND EVALUATION OF BRAIN TARGETED ESLICARBAMAZEPINE ACETATE NANOSUSPENSION FOR EPILEPSY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2021 [Cited : ]; 7(2) : 1469-1482. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_DEVELOPMENT_AND_EVALUATION_OF_BRAIN_TARGETED_ESLICARBAMAZEPINE_ACETATE_NANOSUSPENSION_FOR_EPILEPSY_ijariie14084.pdf
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