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Title: :  DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG
PaperId: :  14146
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 7 Issue 3 2021
DUI:    16.0415/IJARIIE-14146
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Balaji EdupugantiSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.
Sreemukha VeerugantiSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.
Lavanya KonduruSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.
Bhavana ManupatiSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.

Abstract

Pharmacy
Asenapine , Stability indicating method, Degradation products, Validation.
A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for the determination of Asenapine, using a C-18 Inertsil ODS-3 (250mm×4.6mm×5μm) column and a mobile phase composed of 0.05M Ammonium Acetate Buffer : CAN (50:50,v/v), pH of buffer is 4.8 adjusted with acetic acid. The retention times of Asenapine was found to be 5.1 min. The developed method was validated as per International Conference on Harmonization guidelines for the parameters of accuracy, precision, specificity, linearity, solution stability and system suitability. Linearity was established for Asenapine in the range of 1-3μg/ml. The percentage recoveries of Asenapine was found to be in the range of 98.26 - 100.47%. Asenapine was subjected to acid, alkali hydrolysis, oxidation, thermal and photolytic degradation. The degradation studies indicated, Asenapine to be susceptible to acid hydrolysis, base hydrolysis, oxidation and thermal degradation. The degradation products of Cariprazine in acidic, basic, oxidative and thermal conditions were well resolved from the pure drug with significant differences in the retention time values. This method can be successfully employed for quantitative analysis of Asenapine in bulk drugs.

Citations

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IJARIIE Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. "DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG" International Journal Of Advance Research And Innovative Ideas In Education Volume 7 Issue 3 2021 Page 86-95
MLA Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. "DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG." International Journal Of Advance Research And Innovative Ideas In Education 7.3(2021) : 86-95.
APA Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, & Bhavana Manupati. (2021). DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG. International Journal Of Advance Research And Innovative Ideas In Education, 7(3), 86-95.
Chicago Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. "DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG." International Journal Of Advance Research And Innovative Ideas In Education 7, no. 3 (2021) : 86-95.
Oxford Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. 'DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG', International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 3, 2021, p. 86-95. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_STABILITY_INDICATING_RP_HPLC_METHOD_FOR_DETERMINATION_OF_ASENAPINE_IN_BULK_DRUG_ijariie14146.pdf (Accessed : ).
Harvard Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. (2021) 'DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG', International Journal Of Advance Research And Innovative Ideas In Education, 7(3), pp. 86-95IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_STABILITY_INDICATING_RP_HPLC_METHOD_FOR_DETERMINATION_OF_ASENAPINE_IN_BULK_DRUG_ijariie14146.pdf (Accessed : )
IEEE Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati, "DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG," International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 3, pp. 86-95, May-Jun 2021. [Online]. Available: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_STABILITY_INDICATING_RP_HPLC_METHOD_FOR_DETERMINATION_OF_ASENAPINE_IN_BULK_DRUG_ijariie14146.pdf [Accessed : ].
Turabian Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. "DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 7 number 3 ().
Vancouver Balaji Edupuganti, Sreemukha Veeruganti, Lavanya Konduru, and Bhavana Manupati. DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ASENAPINE IN BULK DRUG. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2021 [Cited : ]; 7(3) : 86-95. Available from: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_STABILITY_INDICATING_RP_HPLC_METHOD_FOR_DETERMINATION_OF_ASENAPINE_IN_BULK_DRUG_ijariie14146.pdf
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