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Title: :  DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS
PaperId: :  14312
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 7 Issue 3 2021
DUI:    16.0415/IJARIIE-14312
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Muthyala AnithaSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.
Banoth SravaniSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.
Gundu Swathi,St.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.
Peddineni DivyasreeSt.Peter’s Institute of Pharmaceutical Science,Hanmakonda,Warangal,Telangana,India.

Abstract

Pharmacy
Mucoadhesive films, Frovatriptan, Migraine, HPMC K15, Beta-cyclodextrin, Eudragit L 100, Chitosan
Formulation development for new drugs, an extension of formulations, finding an alternative to conventional dosage forms for better therapeutic response are some of the research impetus in Pharmaceutical F and D. The new -untried routes of administration are also an avenue that can be explored. Under this research frovatriptan, an antimigraine, BCS class II drug is formulated into mucoadhesive films. Frovatriptan shows 40 to 50% oral bioavailability owing to its low solubility and degradation in GIT. Mucoadhesive films can be an effective formulation for this drug owing to its good permeability. Direct absorption in blood and preventing GIT degradation by mucoadhesion on buccal mucosa can be two rationales stated for the improvement of bioavailability of frovatriptan via mucoadhesive films. Migraine strikes as abrupt and disturbing health situation and needs immediate treatment. Thus, the mucoadhesive film can be more promising than oral tablets for frovatriptan in the treatment of migraine. Blank mucoadhesive films were prepared using various combinations of. HPMC K15, Eudragit L 100, whereas concentrations of chitosan, PVA, beta-cyclodextrin, Na CMC were selected from the literature survey. Later 2.5 mg per 2 × 2 cm2 drug-loaded formulations were developed and optimized. Factorial design of 32 models suggested F1 be optimized batch. Evaluation of films for mechanical and drug release studies along with stability study suggested that mucoadhesive films can be a successful formulation for frovatriptan for the management of migraine. Such formulation can have commercial applications, too, as no such formulation is yet available.

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IJARIIE Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. "DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS" International Journal Of Advance Research And Innovative Ideas In Education Volume 7 Issue 3 2021 Page 888-898
MLA Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. "DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS." International Journal Of Advance Research And Innovative Ideas In Education 7.3(2021) : 888-898.
APA Muthyala Anitha, Banoth Sravani, Gundu Swathi,, & Peddineni Divyasree. (2021). DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS. International Journal Of Advance Research And Innovative Ideas In Education, 7(3), 888-898.
Chicago Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. "DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS." International Journal Of Advance Research And Innovative Ideas In Education 7, no. 3 (2021) : 888-898.
Oxford Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. 'DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS', International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 3, 2021, p. 888-898. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALAUATION_OF_FROVATRIPTAN_BIOADHESIVE_FILMS_ijariie14312.pdf (Accessed : ).
Harvard Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. (2021) 'DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS', International Journal Of Advance Research And Innovative Ideas In Education, 7(3), pp. 888-898IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALAUATION_OF_FROVATRIPTAN_BIOADHESIVE_FILMS_ijariie14312.pdf (Accessed : )
IEEE Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree, "DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS," International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 3, pp. 888-898, May-Jun 2021. [Online]. Available: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALAUATION_OF_FROVATRIPTAN_BIOADHESIVE_FILMS_ijariie14312.pdf [Accessed : ].
Turabian Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. "DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 7 number 3 ().
Vancouver Muthyala Anitha, Banoth Sravani, Gundu Swathi,, and Peddineni Divyasree. DEVELOPMENT AND EVALAUATION OF FROVATRIPTAN BIOADHESIVE FILMS. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2021 [Cited : ]; 7(3) : 888-898. Available from: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_EVALAUATION_OF_FROVATRIPTAN_BIOADHESIVE_FILMS_ijariie14312.pdf
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