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Title: :  FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS
PaperId: :  15537
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 7 Issue 5 2021
DUI:    16.0415/IJARIIE-15537
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
CH.PRATHYUSHAKGR Institute of Technology and Management
Dr.V.ANJANEYULUKGR Institute of Technology and Management
Dr.G.VIJAYA KUMARKGR Institute of Technology and Management

Abstract

Pharmacy
Posaconaole; β- Cyclodextrin; HPMC; Carbopol; Mucoadhesive
Enalapril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC E15LV. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The in vitro release profiles of Enalapril from PRT prepared using HPMC E15LV as retarding polymer are characterized by a predetermined lag time (4.1±0.2 h for K6+F4 ), the duration of which depends on the kind and amount of the polymeric layer applied on the cores as well as type of superdisintegrant in core tablet. The developed system offers a simple and novel technique for pulse release of drugs. From the results it is concluded that the PRT we prepared could achieve a rapid release after lag time of 4±0.2h with the relatively low variability. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern.

Citations

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IJARIIE CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. "FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS" International Journal Of Advance Research And Innovative Ideas In Education Volume 7 Issue 5 2021 Page 1481-1492
MLA CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. "FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS." International Journal Of Advance Research And Innovative Ideas In Education 7.5(2021) : 1481-1492.
APA CH.PRATHYUSHA, Dr.V.ANJANEYULU, & Dr.G.VIJAYA KUMAR. (2021). FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS. International Journal Of Advance Research And Innovative Ideas In Education, 7(5), 1481-1492.
Chicago CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. "FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS." International Journal Of Advance Research And Innovative Ideas In Education 7, no. 5 (2021) : 1481-1492.
Oxford CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. 'FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS', International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 5, 2021, p. 1481-1492. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_POSACONAZOLE_MUCOADHESIVE_TABLETS_ijariie15537.pdf (Accessed : ).
Harvard CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. (2021) 'FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS', International Journal Of Advance Research And Innovative Ideas In Education, 7(5), pp. 1481-1492IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_POSACONAZOLE_MUCOADHESIVE_TABLETS_ijariie15537.pdf (Accessed : )
IEEE CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR, "FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS," International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 5, pp. 1481-1492, Sep-Oct 2021. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_POSACONAZOLE_MUCOADHESIVE_TABLETS_ijariie15537.pdf [Accessed : ].
Turabian CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. "FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 7 number 5 ().
Vancouver CH.PRATHYUSHA, Dr.V.ANJANEYULU, and Dr.G.VIJAYA KUMAR. FORMULATION AND EVALUATION OF POSACONAZOLE MUCOADHESIVE TABLETS. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2021 [Cited : ]; 7(5) : 1481-1492. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_POSACONAZOLE_MUCOADHESIVE_TABLETS_ijariie15537.pdf
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