Call for Papers:Vol.10 Issue.6

Submission
Last date		 30-Dec-2024
Acceptance Status In One Day
Paper Publish In Two Days
Submit ManuScript

News & Updates

Submit Article

Dear Authors, Article publish in our journal for Volume-10,Issue-6. For article submission on below link: Submit Manuscript


Join As Board

Dear Reviewer, You can join our Reviewer team without given any charges in our journal. Submit Details on below link: Join As Board


Paper Publication Charges

IJARIIE APP
Download Android App

For Authors

Archives

IJARIIE Board

Downloads

Android App

Download IJARIIE APP

Authors

Title: :  Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets
PaperId: :  15750
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 7 Issue 6 2021
DUI:    16.0415/IJARIIE-15750
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
K.HarithaKrishna Teja Pharmacy College,
Mrs.A.LavanyaKrishna Teja Pharmacy College,
Dr.K.UmashankarKrishna Teja Pharmacy College,
Dr.M.KishorebabuKrishna Teja Pharmacy College,

Abstract

Pharmacy
Floating, Press-coated, HPMC K100M, HPMC E15LV, Pulsatile, Delivery
Enalapril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disintegrants crosprovidone and croscarmellose sodium. A press-coated tablet (barrier layer) contained the polymer carrageenan, xanthan gum, HPMC K4M, and HPMC E15LV. The buoyant layer was optimized with HPMC K100M, sodium bicarbonate, and citric acid. The tablets were evaluated for physical characteristics, floating lag time, swelling index, FTIR, DSC, and in vitro and in vivo behavior. The 5% superdisintgrant showed good results. The FTIR and DSC study predicted no chemical interactions between the drug and excipients. The formulation containing xanthan gum showed drug retaining abilities, but failed to float. The tablet containing HPMC K15M showed a high swelling index. The in vitro release profiles of Enalapril from PRT prepared using HPMC E15LV as retarding polymer are characterized by a predetermined lag time (4.1±0.2 h for K6+F4 ), the duration of which depends on the kind and amount of the polymeric layer applied on the cores as well as type of superdisintegrant in core tablet. The developed system offers a simple and novel technique for pulse release of drugs. From the results it is concluded that the PRT we prepared could achieve a rapid release after lag time of 4±0.2h with the relatively low variability. The release mechanism of the tablet followed the Korsmeyer-Peppas equation and a first-order release pattern.

Citations

Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.

IJARIIE K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. "Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets" International Journal Of Advance Research And Innovative Ideas In Education Volume 7 Issue 6 2021 Page 1098-1111
MLA K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. "Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets." International Journal Of Advance Research And Innovative Ideas In Education 7.6(2021) : 1098-1111.
APA K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, & Dr.M.Kishorebabu. (2021). Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets. International Journal Of Advance Research And Innovative Ideas In Education, 7(6), 1098-1111.
Chicago K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. "Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets." International Journal Of Advance Research And Innovative Ideas In Education 7, no. 6 (2021) : 1098-1111.
Oxford K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. 'Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets', International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 6, 2021, p. 1098-1111. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Design_and_Characterization_of_Chronotherapeutic_Drug_Delivery_of_Enalapril_Tablets_ijariie15750.pdf (Accessed : ).
Harvard K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. (2021) 'Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets', International Journal Of Advance Research And Innovative Ideas In Education, 7(6), pp. 1098-1111IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Design_and_Characterization_of_Chronotherapeutic_Drug_Delivery_of_Enalapril_Tablets_ijariie15750.pdf (Accessed : )
IEEE K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu, "Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets," International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 6, pp. 1098-1111, Nov-Dec 2021. [Online]. Available: https://ijariie.com/AdminUploadPdf/Design_and_Characterization_of_Chronotherapeutic_Drug_Delivery_of_Enalapril_Tablets_ijariie15750.pdf [Accessed : ].
Turabian K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. "Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 7 number 6 ().
Vancouver K.Haritha, Mrs.A.Lavanya, Dr.K.Umashankar, and Dr.M.Kishorebabu. Design and Characterization of Chronotherapeutic Drug Delivery of Enalapril Tablets. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2021 [Cited : ]; 7(6) : 1098-1111. Available from: https://ijariie.com/AdminUploadPdf/Design_and_Characterization_of_Chronotherapeutic_Drug_Delivery_of_Enalapril_Tablets_ijariie15750.pdf
BibTex EndNote RefMan RefWorks

Number Of Downloads



Save in Google Drive

Similar-Paper

TitleArea of ResearchAuther NameAction
A comprehensive review on Flaxseeds: Nutritional profile, food uses and health benefitsPharmacyMs. Samruddhi Rajpure Download
A comprehensive review on Enicostemma Littorale Blume as an Ayurvedic HerbPharmacyMr. Prasad Bhopale Download
REVIEW ON SHANKHPUSHPI IN NEUROLOGICAL DISORDERSpharmacognosyAbhilash Kutlehria Download
"MARFAN SYNDROME: A COMPREHENSIVE GUIDE TO PATHOGENESIS, DIAGNOSIS, TREATMENT AND MEDICAL MANAGEMENT"Pharmacy Vishvajit Bharat Waghmare Download
To Study On Etiology, Symptoms, Diagnosis ,Treatment and Therapeutic Outcome Of ‘DENGUE FEVER’PHARMACYMELAM.YESURATNAM Download
A review on Nutritional requirements during pregnancyPharmacy Rode Nikita Shivaji Download
DEVELOPMENT AND CHARACTERIZATION OF ORAL MICRO-PARTICULATE DRUG DELIVERY SYSTEMPharmacyAbhilashkutlehria Download
Composition and Analyzation of Transdermal Diclofenac Sodium PatchesPharmacyAbhilash Kutlehria Download
A REVIEW ON HERBAL MEDICINE PLANTS ARE USED FOR THE TREATMENT OF EYE DISORDERS.PHARMACYManoj AN Download
Validation of Sitagliptin Phosphate & Simvastatin by RP-HPLCPharmaceutical Science Sahil Ravindra Chavhan Download
Method Development and Validation of Kaempferol by using High Performance Liquid ChromatographyPharmacyReena Nanasaheb Autade Download
Cheilocostus Speciosus Traditional Uses And TaxonomyPharmacyRajat Kumar Download
Evaluation of Medicinal Plants for Their Therapeutic Potential in Wound ManagementM. Pharmacy (Pharmacology)Aniket Dhadwal Download
A PROSPECTIVE REVIEW ON TRANSETHASOMAL GEL AS CARRIER FOR ENHANCING TRANSDERMAL DELIVERYPharmaceutical FormulationMohammad amin Yatoo Download
FORMULATION AND EVALUATION OF POLY HERBAL FACE MASKpharmacyVANASHRI TURKE Download
12