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Title: :  Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery
PaperId: :  15791
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 7 Issue 6 2021
DUI:    16.0415/IJARIIE-15791
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
P. JahnaviKrishna Teja Pharmacy College,
Dr. K UmashankarKrishnateja Pharmacy College
Dr.M.Kishorebabu Krishna Teja Pharmacy College,

Abstract

Pharmacy
Lovastatin, lipids, SLNs, micro emulsion, transdermal patch.
Nanoparticles are widely studied drug delivery system because of many benefits like controlled release ability to reach target, smaller particle size, enhancement of therapeutic activity and reduction of toxicity. SLNs (solid lipid nanoparticles) are novel nanoparticulated systems which invited substantial attention as a drug delivery carrier. The design of this study was to develop and evaluate Lovastatin solid lipid nanoparticles, loaded into transdermal patch. Lovastatin, a lipid lowering agent, because of its low bioavailabilty (5%) and shorter biological t ½ is a suitable drug to formulate into transdermal form. SLNs containing drug and non-toxic lipids (stearic acid, cholesterol and glycerol mono stearate), tween 80 and PEG 400 as surfactant and cosurfactant were prepared using micro emulsion process. FTIR study reports indicated that there was no interaction between Lovastatin and other excipients. SLNs were assessed for their particle size, entrapment efficiency, PDI (poly dispersity index) and in vitro studies. Scanning electron microscopy reports shown that the nanoparticles are spherical shape and has size range 132-249 nm. PDI was found out to be in the range of 0.186 – 0.376. Percent entrapment efficiency was between 74.3±0.8 – 93.5±1.8. The SLNs were loaded into a transdermal patch formulated using HPMC in varying concentration. All the prepared patches were assessed for flatness, folding endurance, tensile strength, moisture uptake, moisture content and were determined to be in essential range. The SLNP2 in vitro release rate studies shows better release than remaining formulations (SLNP1 &SLNP3) and it was selected as optimized formulation.

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IJARIIE P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . "Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery" International Journal Of Advance Research And Innovative Ideas In Education Volume 7 Issue 6 2021 Page 1208-1215
MLA P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . "Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery." International Journal Of Advance Research And Innovative Ideas In Education 7.6(2021) : 1208-1215.
APA P. Jahnavi, Dr. K Umashankar, & Dr.M.Kishorebabu . (2021). Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery. International Journal Of Advance Research And Innovative Ideas In Education, 7(6), 1208-1215.
Chicago P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . "Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery." International Journal Of Advance Research And Innovative Ideas In Education 7, no. 6 (2021) : 1208-1215.
Oxford P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . 'Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery', International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 6, 2021, p. 1208-1215. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Formulation_of_Lovastatin_Solid_Lipid_Nanoparticles_For_Transdermal_drug_delivery_ijariie15791.pdf (Accessed : ).
Harvard P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . (2021) 'Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery', International Journal Of Advance Research And Innovative Ideas In Education, 7(6), pp. 1208-1215IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Formulation_of_Lovastatin_Solid_Lipid_Nanoparticles_For_Transdermal_drug_delivery_ijariie15791.pdf (Accessed : )
IEEE P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu , "Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery," International Journal Of Advance Research And Innovative Ideas In Education, vol. 7, no. 6, pp. 1208-1215, Nov-Dec 2021. [Online]. Available: https://ijariie.com/AdminUploadPdf/Formulation_of_Lovastatin_Solid_Lipid_Nanoparticles_For_Transdermal_drug_delivery_ijariie15791.pdf [Accessed : ].
Turabian P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . "Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 7 number 6 ().
Vancouver P. Jahnavi, Dr. K Umashankar, and Dr.M.Kishorebabu . Formulation of Lovastatin Solid Lipid Nanoparticles For Transdermal drug delivery. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2021 [Cited : ]; 7(6) : 1208-1215. Available from: https://ijariie.com/AdminUploadPdf/Formulation_of_Lovastatin_Solid_Lipid_Nanoparticles_For_Transdermal_drug_delivery_ijariie15791.pdf
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