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Title: :  Formulation And Evaluation of Ofloxacin Loaded Floating Microballons
PaperId: :  16109
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 2 2022
DUI:    16.0415/IJARIIE-16109
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Rajani VarunKailash Institute of Pharmacy & Management
J N MishraKailash Institute of Pharmacy & Management
Priyanka MauryaKailash Institute of Pharmacy & Management

Abstract

Pharmacy
Floating Microballons, ofloxacin, controlled drug delivery
The present study involves preparation and evaluation of floating microballoons of Ofloxacin for improving the bioavailability by prolongation of gastric residence time in GIT. Ofloxacin, a sparingly water-soluble drug, was selected and microballoons were prepared by emulsion solvent diffusion method using Eudragit RS-100, CAP as a polymer, in ethyl alcohol and dichloromethane organic solvent system. The formation of a sphere and hollow within the sphere was confirmed through SEM studies. The percentage of drug entrapment and recovery was found to be 75- 80%. The micromeritic properties indicated better flowability and packability of the spheres. The Buoyancy test showed good floatability of Ofloxacin microballoons in the simulated gastric fluid for more than 24 h. In vitro dissolution profile showed prolonged release of drug from the formulations. Thus, microballoons of Ofloxacin with acrylic polymers prepared by emulsion solvent diffusion method show to be an ideal novel floating dosage form that is adaptable to any intragastric condition for controlled drug delivery and enhanced bioavailability.

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IJARIIE Rajani Varun, J N Mishra, and Priyanka Maurya. "Formulation And Evaluation of Ofloxacin Loaded Floating Microballons" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 2 2022 Page 132-137
MLA Rajani Varun, J N Mishra, and Priyanka Maurya. "Formulation And Evaluation of Ofloxacin Loaded Floating Microballons." International Journal Of Advance Research And Innovative Ideas In Education 8.2(2022) : 132-137.
APA Rajani Varun, J N Mishra, & Priyanka Maurya. (2022). Formulation And Evaluation of Ofloxacin Loaded Floating Microballons. International Journal Of Advance Research And Innovative Ideas In Education, 8(2), 132-137.
Chicago Rajani Varun, J N Mishra, and Priyanka Maurya. "Formulation And Evaluation of Ofloxacin Loaded Floating Microballons." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 2 (2022) : 132-137.
Oxford Rajani Varun, J N Mishra, and Priyanka Maurya. 'Formulation And Evaluation of Ofloxacin Loaded Floating Microballons', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 2, 2022, p. 132-137. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Formulation_And_Evaluation_of_Ofloxacin_Loaded_Floating_Microballons_ijariie16109.pdf (Accessed : ).
Harvard Rajani Varun, J N Mishra, and Priyanka Maurya. (2022) 'Formulation And Evaluation of Ofloxacin Loaded Floating Microballons', International Journal Of Advance Research And Innovative Ideas In Education, 8(2), pp. 132-137IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Formulation_And_Evaluation_of_Ofloxacin_Loaded_Floating_Microballons_ijariie16109.pdf (Accessed : )
IEEE Rajani Varun, J N Mishra, and Priyanka Maurya, "Formulation And Evaluation of Ofloxacin Loaded Floating Microballons," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 2, pp. 132-137, Mar-App 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/Formulation_And_Evaluation_of_Ofloxacin_Loaded_Floating_Microballons_ijariie16109.pdf [Accessed : ].
Turabian Rajani Varun, J N Mishra, and Priyanka Maurya. "Formulation And Evaluation of Ofloxacin Loaded Floating Microballons." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 2 ().
Vancouver Rajani Varun, J N Mishra, and Priyanka Maurya. Formulation And Evaluation of Ofloxacin Loaded Floating Microballons. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(2) : 132-137. Available from: https://ijariie.com/AdminUploadPdf/Formulation_And_Evaluation_of_Ofloxacin_Loaded_Floating_Microballons_ijariie16109.pdf
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