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Title: :  RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS
PaperId: :  17388
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 3 2022
DUI:    16.0415/IJARIIE-17388
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr.S. Venkata Saibaba K.v.k college of pharmacy
G.JaideepK.v.k college of pharmacy
V.DeepthishaK.v.k college of pharmacy
N.PreetiK.v.k college of pharmacy
B.SwamyK.v.k college of pharmacy
P.PratiashK.v.k college of pharmacy

Abstract

pharmacy
Cabazitaxel, RP- HPLC, Stress degradation, JEVTANA© – 30mg, ICH
A simple, selective, precise, and stability indicating RP-HPLC method has been developed and validated for analysis of Cabazitaxel, a chemotherapy medication used to treat different types of cancer. The chromatographic separation was achieved on a Agilent ZORBAX Eclipse Plus C18 column with Methanol: Acetonitrile: water (40:40:20 v/v), as mobile phase at a flow rate of 0.9mL/min. Detection was performed at 237nm and a sharp peak was obtained for Cabazitaxel at a retention time of 7.12min. The calibration curve showed a good linear relationship between response and concentration with the equation y = 6816x + 67048, and the regression coefficient was 0.999 over the concentration range 20-120µg/mL. The limit of detection (LOD) and limit of quantification (LOQ) were 0.04µg/ mL and 0.15µg/mL respectively. The method was validated for accuracy, precision, reproducibility, specificity, robustness, and detection and quantification limits, in accordance with ICH guidelines. The method was successfully separated the degraded products from the stress degradation conditions. The wide linearity range, accuracy and simple mobile phase imply the method is suitable for routine quantification of Cabazitaxel with high precision.

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IJARIIE Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. "RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 3 2022 Page 4180-4189
MLA Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. "RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS." International Journal Of Advance Research And Innovative Ideas In Education 8.3(2022) : 4180-4189.
APA Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, & P.Pratiash. (2022). RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS. International Journal Of Advance Research And Innovative Ideas In Education, 8(3), 4180-4189.
Chicago Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. "RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 3 (2022) : 4180-4189.
Oxford Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. 'RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 3, 2022, p. 4180-4189. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/RP_HPLC_METHOD_DEVELOPMENT_AND_VALIDATION_FOR_THE_ESTIMATION_OF_CABAZITAXEL_IN_PHARMACEUTICAL_DOSAGE_FORMS_ijariie17388.pdf (Accessed : ).
Harvard Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. (2022) 'RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS', International Journal Of Advance Research And Innovative Ideas In Education, 8(3), pp. 4180-4189IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/RP_HPLC_METHOD_DEVELOPMENT_AND_VALIDATION_FOR_THE_ESTIMATION_OF_CABAZITAXEL_IN_PHARMACEUTICAL_DOSAGE_FORMS_ijariie17388.pdf (Accessed : )
IEEE Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash, "RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 3, pp. 4180-4189, May-Jun 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/RP_HPLC_METHOD_DEVELOPMENT_AND_VALIDATION_FOR_THE_ESTIMATION_OF_CABAZITAXEL_IN_PHARMACEUTICAL_DOSAGE_FORMS_ijariie17388.pdf [Accessed : ].
Turabian Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. "RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 3 ().
Vancouver Dr.S. Venkata Saibaba , G.Jaideep, V.Deepthisha, N.Preeti, B.Swamy, and P.Pratiash. RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CABAZITAXEL IN PHARMACEUTICAL DOSAGE FORMS. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(3) : 4180-4189. Available from: https://ijariie.com/AdminUploadPdf/RP_HPLC_METHOD_DEVELOPMENT_AND_VALIDATION_FOR_THE_ESTIMATION_OF_CABAZITAXEL_IN_PHARMACEUTICAL_DOSAGE_FORMS_ijariie17388.pdf
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