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Title: :  FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION
PaperId: :  17654
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 4 2022
DUI:    16.0415/IJARIIE-17654
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
TAMBOLI SAIFALIALI-ALLANA COLLEGE OF PHARMACY
REHAN DESHMUKHALI-ALLANA COLLEGE OF PHARMACY
DR. G.J KHANALI-ALLANA COLLEGE OF PHARMACY
SHAIKH MUJEEBALI-ALLANA COLLEGE OF PHARMACY
PATEL RAIHANALI-ALLANA COLLEGE OF PHARMACY
ANSARI MOHD. HAMMADALI-ALLANA COLLEGE OF PHARMACY
MOHD. SHOEB NAWAZALI-ALLANA COLLEGE OF PHARMACY
MAAZ AAQUILALI-ALLANA COLLEGE OF PHARMACY

Abstract

PHARMACY
Captopril, Losartan potassium, HPMC K-4M, HPMC K-100
The purpose of this investigation was to prepare a gastro-retentive drug delivery system of captopril and losartan potassium for treatment and management of hypertension. Matrix Floating tablets of captopril and losartan potassium were prepared using different grades of HPMC K-100 and HPMC K-4M by effervescent technique. Sodium bicarbonate and citric acid was incorporated as a gas-generating agent or effervescent agent. The matrix floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The effect of citric acid on drug release profile and floating properties was investigated. The prepared matrix floating tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for more than 24 hours. A combination of sodium bicarbonate (27mg) and citric acid (13.5mg) was found to achieve optimum in vitro buoyancy. The formulation having HPMC K100 (60mg), HPMC K-4M (25mg) were found to float for longer duration as compared to other formulations and shows good drug release properties

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IJARIIE TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 4 2022 Page 20-28
MLA TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION." International Journal Of Advance Research And Innovative Ideas In Education 8.4(2022) : 20-28.
APA TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, & MAAZ AAQUIL. (2022). FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION. International Journal Of Advance Research And Innovative Ideas In Education, 8(4), 20-28.
Chicago TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 4 (2022) : 20-28.
Oxford TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. 'FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, 2022, p. 20-28. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_CAPTOPRIL_AND_LOSARTAN_POTASSIUM_IN_TREATMENT_AND_MANAGEMENT_OF_HYPERTENSION_ijariie17654.pdf (Accessed : 07 August 2022).
Harvard TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. (2022) 'FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION', International Journal Of Advance Research And Innovative Ideas In Education, 8(4), pp. 20-28IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_CAPTOPRIL_AND_LOSARTAN_POTASSIUM_IN_TREATMENT_AND_MANAGEMENT_OF_HYPERTENSION_ijariie17654.pdf (Accessed : 07 August 2022)
IEEE TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL, "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, pp. 20-28, Jul-Aug 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_CAPTOPRIL_AND_LOSARTAN_POTASSIUM_IN_TREATMENT_AND_MANAGEMENT_OF_HYPERTENSION_ijariie17654.pdf [Accessed : 07 August 2022].
Turabian TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. "FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 4 (07 August 2022).
Vancouver TAMBOLI SAIFALI, REHAN DESHMUKH, DR. G.J KHAN, SHAIKH MUJEEB, PATEL RAIHAN, ANSARI MOHD. HAMMAD, MOHD. SHOEB NAWAZ, and MAAZ AAQUIL. FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF CAPTOPRIL AND LOSARTAN POTASSIUM IN TREATMENT AND MANAGEMENT OF HYPERTENSION. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : 07 August 2022]; 8(4) : 20-28. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_CAPTOPRIL_AND_LOSARTAN_POTASSIUM_IN_TREATMENT_AND_MANAGEMENT_OF_HYPERTENSION_ijariie17654.pdf
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