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Title: :  DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM
PaperId: :  17656
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 4 2022
DUI:    16.0415/IJARIIE-17656
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
MAAZ AAQUIL ALI ALLANA COLLEGE OF PHARMACY
SIDDIK M PATELALI ALLANA COLLEGE OF PHARMACY
KHAN JAVEDALI ALLANA COLLEGE OF PHARMACY
ABDUL BARIALI ALLANA COLLEGE OF PHARMACY
ANSARI MOHD HAMMADALI ALLANA COLLEGE OF PHARMACY
MOHD SHOEB NAWAZALI ALLANA COLLEGE OF PHARMACY
SHAIKH MUJEEB ALI ALLANA COLLEGE OF PHARMACY
TAMBOLI SAIFALIALI ALLANA COLLEGE OF PHARMACY

Abstract

PHARMACY
Keyword: Ramelteon, RP-HPLC Method Development, Anti-Anxiety, Validation.
Abstract: A simple, accurate and precise reverse phase HPLC method validated for the determination of Ramelteon Tablet dosage form. Chromatography was carried on C18 column using a mixture of Methanol: water (0.1 % OPA), pH 2.7 (in the ratio 60:40 v/v) as the mobile phase at a flow rate of 0.7 ml /min with detection at 282 nm by ultraviolet detector i.e. incorporated in HPLC. The retention time of the drug was found to be 5.860 min. The method validation proofs were carried out as per the ICH guidelines. The developed method was validated for linearity over a range of 10μg/ml to 60μg/ml, with a correlation coefficient of 0.999, which shows the method is quite linear. Further precision, ruggedness, accuracy was validated. The %RSD for system precision was observed to be Less Than 2, whereas the method precision was observed to be 0.456. And for ruggedness the observations were found to be 0.5 and 0.4 respectively. The average recovery of 100.0% indicates the capability of the method, and finally no significant differences in % RSD values with respective Retention time prove the robustness of the method. As per ICH guidelines, method validation results are in good agreement. The proposed approach is effective and can be applied for the tablet dosage form estimation of Ramelteon in tablet dosage form.

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IJARIIE MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. "DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 4 2022 Page 80-92
MLA MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. "DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education 8.4(2022) : 80-92.
APA MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , & TAMBOLI SAIFALI. (2022). DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM. International Journal Of Advance Research And Innovative Ideas In Education, 8(4), 80-92.
Chicago MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. "DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 4 (2022) : 80-92.
Oxford MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. 'DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, 2022, p. 80-92. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_METHOD_FOR_THE_DETERMINATION_OF_RAMELTEON_IN_BULK_AND_PHARMACEUTICAL_DOSAGE_FORM_ijariie17656.pdf (Accessed : ).
Harvard MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. (2022) 'DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM', International Journal Of Advance Research And Innovative Ideas In Education, 8(4), pp. 80-92IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_METHOD_FOR_THE_DETERMINATION_OF_RAMELTEON_IN_BULK_AND_PHARMACEUTICAL_DOSAGE_FORM_ijariie17656.pdf (Accessed : )
IEEE MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI, "DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, pp. 80-92, Jul-Aug 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_METHOD_FOR_THE_DETERMINATION_OF_RAMELTEON_IN_BULK_AND_PHARMACEUTICAL_DOSAGE_FORM_ijariie17656.pdf [Accessed : ].
Turabian MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. "DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 4 ().
Vancouver MAAZ AAQUIL , SIDDIK M PATEL, KHAN JAVED, ABDUL BARI, ANSARI MOHD HAMMAD, MOHD SHOEB NAWAZ, SHAIKH MUJEEB , and TAMBOLI SAIFALI. DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR THE DETERMINATION OF RAMELTEON IN BULK AND PHARMACEUTICAL DOSAGE FORM. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(4) : 80-92. Available from: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_METHOD_FOR_THE_DETERMINATION_OF_RAMELTEON_IN_BULK_AND_PHARMACEUTICAL_DOSAGE_FORM_ijariie17656.pdf
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