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Title: :  Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules
PaperId: :  17698
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 4 2022
DUI:    16.0415/IJARIIE-17698
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
CH.Shanthi PriyaSurabhi DayakarRao College of Pharmacy
Dr M Venkata RamanaSurabhi DayakarRao College of Pharmacy
Dr Rangu NirmalaSurabhi DayakarRao College of Pharmacy
Samreen begumSurabhi DayakarRao College of Pharmacy
R.VijaySurabhi DayakarRao College of Pharmacy
BhavanaSurabhi DayakarRao College of Pharmacy
A.SandhyaSurabhi DayakarRao College of Pharmacy
SamreenSurabhi DayakarRao College of Pharmacy

Abstract

Pharmacy
Controlled release, floating, capsules, Ciprofloxacin, buoyancy
Capsules are solid preparations in which the drug substances and/or excipients are enclosed in either a soft or hard soluble shell. The shell is normally made of gelatin or suitable polymeric material and results in a simple, tasteless, odourless, elegant, easy to swallow dosage form without the need for a secondary coating step. Controlled release dosage forms have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of ciprofloxacin leads to poor dissolution & hence variation in bioavailability. The purpose of present investigation was to formulate and evaluate controlled release floating capsules of ciprofloxacin with improved solubility & dissolution rate. In present study granules using various carriers like mannitol & lactose in different ratios were prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose (18.41-24.22), bulk density, tapped density, compressibility index (11.31-12.75) & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies such as weight variation, release study, buoyancy & floating duration (more than 6 hrs.). We can conclude that all the parameters were within the acceptable limits.

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IJARIIE CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. "Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 4 2022 Page 383-388
MLA CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. "Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules." International Journal Of Advance Research And Innovative Ideas In Education 8.4(2022) : 383-388.
APA CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, & Samreen. (2022). Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules. International Journal Of Advance Research And Innovative Ideas In Education, 8(4), 383-388.
Chicago CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. "Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 4 (2022) : 383-388.
Oxford CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. 'Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, 2022, p. 383-388. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Formulation___Evaluation_of_Ciprofloxacin_Controlled_Release_Floating___Capsules_ijariie17698.pdf (Accessed : ).
Harvard CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. (2022) 'Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules', International Journal Of Advance Research And Innovative Ideas In Education, 8(4), pp. 383-388IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Formulation___Evaluation_of_Ciprofloxacin_Controlled_Release_Floating___Capsules_ijariie17698.pdf (Accessed : )
IEEE CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen, "Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, pp. 383-388, Jul-Aug 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/Formulation___Evaluation_of_Ciprofloxacin_Controlled_Release_Floating___Capsules_ijariie17698.pdf [Accessed : ].
Turabian CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. "Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 4 ().
Vancouver CH.Shanthi Priya, Dr M Venkata Ramana, Dr Rangu Nirmala, Samreen begum, R.Vijay, Bhavana, A.Sandhya, and Samreen. Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(4) : 383-388. Available from: https://ijariie.com/AdminUploadPdf/Formulation___Evaluation_of_Ciprofloxacin_Controlled_Release_Floating___Capsules_ijariie17698.pdf
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