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Title: :  DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES
PaperId: :  17741
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 4 2022
DUI:    16.0415/IJARIIE-17741
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
A Sneha Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana (state) 50231, India
V Kavitha Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana (state) 50231, India
Shafiya begumSurabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana (state) 50231, India
Samreen begum Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana (state) 50231, India
J Bikshapahi Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana (state) 50231, India
B Krishnaveni Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana (state) 50231, India

Abstract

PHARMACEUTICAL SCIENCES
Clarithromycin ,HPMC ,Microspheres, Bio adhesive
In the present work, bioadhesive microspheres of Clarithromycin using Sodium alginate along with HPMCK100M, HPMCK15M, as copolymers were formulated to deliver Clarithromycin via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Clarithromycin microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-903µm and are suitable for bioadhesive microspheres for oral administration.Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion.The in-vitro mucoadhesive study demonstrated that microspheres of Clarithromycin using sodium alginate along with HPMCK15M as copolymer adhered to the mucus to a greater extent than the microspheres of Clarithromycin using sodium alginate along with HPMCK100M as copolymer.

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IJARIIE A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. "DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 4 2022 Page 873-879
MLA A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. "DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES." International Journal Of Advance Research And Innovative Ideas In Education 8.4(2022) : 873-879.
APA A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, & B Krishnaveni. (2022). DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES. International Journal Of Advance Research And Innovative Ideas In Education, 8(4), 873-879.
Chicago A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. "DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 4 (2022) : 873-879.
Oxford A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. 'DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, 2022, p. 873-879. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_IN_VITRO_CHARACTERIZATION_OF_CLARITHROMYCIN_MICROSPHERES_ijariie17741.pdf (Accessed : ).
Harvard A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. (2022) 'DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES', International Journal Of Advance Research And Innovative Ideas In Education, 8(4), pp. 873-879IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_IN_VITRO_CHARACTERIZATION_OF_CLARITHROMYCIN_MICROSPHERES_ijariie17741.pdf (Accessed : )
IEEE A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni, "DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 4, pp. 873-879, Jul-Aug 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_IN_VITRO_CHARACTERIZATION_OF_CLARITHROMYCIN_MICROSPHERES_ijariie17741.pdf [Accessed : ].
Turabian A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. "DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 4 ().
Vancouver A Sneha, V Kavitha, Shafiya begum, Samreen begum, J Bikshapahi, and B Krishnaveni. DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(4) : 873-879. Available from: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_IN_VITRO_CHARACTERIZATION_OF_CLARITHROMYCIN_MICROSPHERES_ijariie17741.pdf
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