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Title: :  FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE
PaperId: :  18155
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 5 2022
DUI:    16.0415/IJARIIE-18155
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Malay PaulMallige College of Pharmacy, Silvepura, Bangalore, Karnataka, India
Keerthy H.SMallige College of Pharmacy, Silvepura, Bangalore, Karnataka, India
Dr. Shivanand K MuttaMallige College of Pharmacy, Silvepura, Bangalore, Karnataka, India
F.R. SheebaMallige College of Pharmacy, Silvepura, Bangalore, Karnataka, India
Dr. Ashvini H MMallige College of Pharmacy, Silvepura, Bangalore, Karnataka, India
Mukesh SharmaMallige College of Pharmacy, Silvepura, Bangalore, Karnataka, India

Abstract

Pharmacy
Diltiazem hydrochloride, microsphere, Ethyl cellulose, HPMC, Gelatin, in-vitro evaluation
The aim of the present work was to prepare controlled released microspheres of Diltiazem Hydrochloride to sustain the release of the drug, Diltiazem Hydrochloride. Diltizam Hydrochloride loaded controlled microspheres were prepared by solvent evaporation technique with combination of polymers (Ethyl cellulose, HPMC K4M and Gelatin). Nine formulations were prepared with different ratios of combination of EC, HPMC K4M & Gelatin. The prepared Microspheres were characterized for physical characteristics such as particle size, particle shape and surface morphology by scanning electron microscopy, percentage yield, drug entrapment efficiency, and In-vitro drug release studies. The obtained microspheres were found to be spherical, free flowing and have a particle size ranging between 127.8-158µm suitable for oral delivery. Percentage drug entrapment efficiency was found to be 75.37 – 89.24%. Scanning electron microscopy and particle size analysis revealed differences between the formulation as to their appearance and size distribution. Diltiazem Hydrochloride loaded Microspheres that effectively sustain the drug release more than 12 h. Finally the study confirmed that various Diltiazem Hydrochloride loaded Ethyl cellulose, HPMC K4M & Gelatin microspheres formulations could be developed that effectively sustain the drug release for a desired period by varing the ratio of EC , HPMC K4M & Gelatin polymers.

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IJARIIE Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 5 2022 Page 184-191
MLA Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE." International Journal Of Advance Research And Innovative Ideas In Education 8.5(2022) : 184-191.
APA Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, & Mukesh Sharma. (2022). FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE. International Journal Of Advance Research And Innovative Ideas In Education, 8(5), 184-191.
Chicago Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 5 (2022) : 184-191.
Oxford Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. 'FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 5, 2022, p. 184-191. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_CONTROLLED_RELEASE_MICROSPHERES_OF_DILTIAZEM_HYDROCHLORIDE_BY_SOLVENT_EVAPORATION_TECHNIQUE_ijariie18155.pdf (Accessed : ).
Harvard Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. (2022) 'FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE', International Journal Of Advance Research And Innovative Ideas In Education, 8(5), pp. 184-191IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_CONTROLLED_RELEASE_MICROSPHERES_OF_DILTIAZEM_HYDROCHLORIDE_BY_SOLVENT_EVAPORATION_TECHNIQUE_ijariie18155.pdf (Accessed : )
IEEE Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma, "FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 5, pp. 184-191, Sep-Oct 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_CONTROLLED_RELEASE_MICROSPHERES_OF_DILTIAZEM_HYDROCHLORIDE_BY_SOLVENT_EVAPORATION_TECHNIQUE_ijariie18155.pdf [Accessed : ].
Turabian Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 5 ().
Vancouver Malay Paul, Keerthy H.S, Dr. Shivanand K Mutta, F.R. Sheeba, Dr. Ashvini H M, and Mukesh Sharma. FORMULATION AND EVALUATION OF CONTROLLED RELEASE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY SOLVENT EVAPORATION TECHNIQUE. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(5) : 184-191. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_CONTROLLED_RELEASE_MICROSPHERES_OF_DILTIAZEM_HYDROCHLORIDE_BY_SOLVENT_EVAPORATION_TECHNIQUE_ijariie18155.pdf
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