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Title: :  Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis
PaperId: :  18262
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 5 2022
DUI:    16.0415/IJARIIE-18262
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Nooreen Unissaavanthi institute of pharmaceutical sciences
Gopi Swapnaavanthi institute of pharmaceutical sciences
Usha Kondlaavanthi institute of pharmaceutical sciences
P.V.Pavan Kumaravanthi institute of pharmaceutical sciences

Abstract

pharmacy
2-amino-pyran, staphylococcus aureus, escherichia coli, antioxidant activity, breast cancer.
Abstract---Using ethanol as a solvent, heterocyclic hexagonal rings for 2-amino-pyran derivatives (I33-I40) were produced by reacting a mole of chalcones derivatives with a mole of malononitrile. Physical properties such as melting point, colour, and molecular weight and spectroscopic measurements such as the infrared spectrum, [1H-NMR], [13C-NMR] spectrum were used to confirm the accuracy of the prepared compounds' compositions. The biological activity of various produced compounds was investigated in two species of pathogenic bacteria, one of which is Gram-positive, Staphylococcus aureus, and the other, Gram-negative, Escherichia coli. Chemical solutions for the two substances (I25, I32) with concentrations (0,01, 0.001, 0.0001) mg /ml were created using a solvent DMSO and Multer Hinton Agar growth medium. The antibiotic Ciprofloxacin was utilized as a control sample for the diffusion sensitivity test of the bacterial isolates used in the investigation. Using DPPH root and varied concentrations, the impact of chemical (I32) on the elimination of free radicals was also investigated. Breast cancer cells were taken from Baghdad's Medical City and used to test the efficiency of several produced chemicals against them. 200 μl of the prepared concentrations of the compounds produced for the research (25, 50, 100, 200) g/ml were added to the pits at three concentrations, cytotoxicity tests were conducted in three duplicates, and (IC50) values were computed. The cytotoxicity impact of the compounds was evaluated and produced using MTT and solute solutions on breast cancer cells and the ordinary cell line WRL68 for comparison.

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IJARIIE Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. "Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 5 2022 Page 742-755
MLA Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. "Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis." International Journal Of Advance Research And Innovative Ideas In Education 8.5(2022) : 742-755.
APA Nooreen Unissa, Gopi Swapna, Usha Kondla, & P.V.Pavan Kumar. (2022). Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis. International Journal Of Advance Research And Innovative Ideas In Education, 8(5), 742-755.
Chicago Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. "Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 5 (2022) : 742-755.
Oxford Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. 'Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 5, 2022, p. 742-755. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Evaluation_of_the_bacterial__antioxidant_and_anticancer_activity_of_pyrene_derivatives_and_their_synthesis_ijariie18262.pdf (Accessed : ).
Harvard Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. (2022) 'Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis', International Journal Of Advance Research And Innovative Ideas In Education, 8(5), pp. 742-755IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Evaluation_of_the_bacterial__antioxidant_and_anticancer_activity_of_pyrene_derivatives_and_their_synthesis_ijariie18262.pdf (Accessed : )
IEEE Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar, "Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 5, pp. 742-755, Sep-Oct 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/Evaluation_of_the_bacterial__antioxidant_and_anticancer_activity_of_pyrene_derivatives_and_their_synthesis_ijariie18262.pdf [Accessed : ].
Turabian Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. "Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 5 ().
Vancouver Nooreen Unissa, Gopi Swapna, Usha Kondla, and P.V.Pavan Kumar. Evaluation of the bacterial, antioxidant and anticancer activity of pyrene derivatives and their synthesis. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(5) : 742-755. Available from: https://ijariie.com/AdminUploadPdf/Evaluation_of_the_bacterial__antioxidant_and_anticancer_activity_of_pyrene_derivatives_and_their_synthesis_ijariie18262.pdf
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