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Title: :  FABRICATION OF TINIDAZOLE LOADED MICROSPONGE
PaperId: :  18547
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 6 2022
DUI:    16.0415/IJARIIE-18547
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr. Lagnajit MahapatraHaldia Institute of Pharmacy
Tamanna AfnanHaldia Institute of Pharmacy
Dr.Suman PattanayakHaldia Institute of Pharmacy
Dr.Lakshmi Kanta KanthalHaldia Institute of Pharmacy
Ankita BhuniaHaldia Institute of Pharmacy
HasanuzamanHaldia Institute of Pharmacy
Deepanjan Mondal Haldia Institute of Pharmacy

Abstract

Pharmacy
Microsponge, HPMC, tinidazole, PVA, Giardiasis, Quasi-emulsion solvent diffusion method.
Microsponge drug delivery system is a novel drug delivery system which is based on polymer-based microsphere which contains voids having large porous surface. Microsponges are spherical in nature. They are used for sustain drug delivery while entrapping the drugs in the small pores which regulates the flow of the drug out of the porous surface. The main aim of formulating this delivery system is to incorporate the drug in minimum dose with enhance stability, reducing the side effect without compromising its efficacy. Microsponges are formulated for oral route; microsponges can control its drug delivery upto 12 hours. The aim of the present study to develop HPMC fabricated microsponge where DCM used as internal phase and PVA used as external phase and the drug entrapped here is Tinidazole, it is an anti-parasitic and antibiotic classified drug. It is used to treat Giardiasis, Giardiasis is a parasite intestinal infection caused by Giardia duodenalis, this is also known as G.lambia & G.intestinalis. In conventional dosage forms there is chance of having colonic cancer, ulcerative colitis and due to frequent dose requirements, the patient compliance is very low, so microsponges are advantageous in this case. Microsponges are stable at pH range 1-11 and upto 1300C temperature. As Microsponges are obtained from various methods the common being Quasi-Solvent emulsions diffusion method. It is obtained by preparing two phases i.e., external and internal phase and mixed together and stirred while giving heat as the solvent evaporates it leaves quasi emulsion globules. Once the microsponges are produced, they are dried in oven at 40℃ and evaluation is done. Various Evaluation parameters such as particle size, morphology, percent yield, drug interaction etc. are evaluated.

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IJARIIE Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . "FABRICATION OF TINIDAZOLE LOADED MICROSPONGE" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 6 2022 Page 160-167
MLA Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . "FABRICATION OF TINIDAZOLE LOADED MICROSPONGE." International Journal Of Advance Research And Innovative Ideas In Education 8.6(2022) : 160-167.
APA Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, & Deepanjan Mondal . (2022). FABRICATION OF TINIDAZOLE LOADED MICROSPONGE. International Journal Of Advance Research And Innovative Ideas In Education, 8(6), 160-167.
Chicago Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . "FABRICATION OF TINIDAZOLE LOADED MICROSPONGE." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 6 (2022) : 160-167.
Oxford Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . 'FABRICATION OF TINIDAZOLE LOADED MICROSPONGE', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 6, 2022, p. 160-167. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FABRICATION_OF_TINIDAZOLE_LOADED_MICROSPONGE_ijariie18547.pdf (Accessed : 24 June 2023).
Harvard Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . (2022) 'FABRICATION OF TINIDAZOLE LOADED MICROSPONGE', International Journal Of Advance Research And Innovative Ideas In Education, 8(6), pp. 160-167IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FABRICATION_OF_TINIDAZOLE_LOADED_MICROSPONGE_ijariie18547.pdf (Accessed : 24 June 2023)
IEEE Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal , "FABRICATION OF TINIDAZOLE LOADED MICROSPONGE," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 6, pp. 160-167, Nov-Dec 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/FABRICATION_OF_TINIDAZOLE_LOADED_MICROSPONGE_ijariie18547.pdf [Accessed : 24 June 2023].
Turabian Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . "FABRICATION OF TINIDAZOLE LOADED MICROSPONGE." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 6 (24 June 2023).
Vancouver Dr. Lagnajit Mahapatra, Tamanna Afnan, Dr.Suman Pattanayak, Dr.Lakshmi Kanta Kanthal, Ankita Bhunia, Hasanuzaman, and Deepanjan Mondal . FABRICATION OF TINIDAZOLE LOADED MICROSPONGE. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : 24 June 2023]; 8(6) : 160-167. Available from: https://ijariie.com/AdminUploadPdf/FABRICATION_OF_TINIDAZOLE_LOADED_MICROSPONGE_ijariie18547.pdf
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