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Title: :  Enhancement of solubility and dissoulation of a drug Mefenamic acid
PaperId: :  18814
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 8 Issue 6 2022
DUI:    16.0415/IJARIIE-18814
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mahesh BhattSmt Manjira Devi shikashan avm prashikshan sansthan Hitanu, Dhanari Uttarkashi (Uttrakhand)
Chitra RanaSmt Manjira Devi shikashan avm prashikshan sansthan Hitanu, Dhanari Uttarkashi (Uttrakhand)

Abstract

Pharmacy
Mefenamic acid; Chitosan; Dissolution enhancement; Ball milling ;Amorphization.
Mefenamic acid is a poorly water-soluble drug (BCS Class II), widely prescribed formild to moderate pain, primary dysmenorrheal, rheumatoid arthritis, osteoarthritis and otherjoint diseases.Inorder to increase its solubility and dissolution rate, various solubilityenhancement methods like solvent evaporation, trituration, ball milling, physical mixing andnon-solvent methods in chitosan carrier, with different mefenamic acid to chitosan ratioshave been investigated. Drug-carrier interactions were investigated by differential scanningcalorimetry and FT-IR spectroscopy. The studies showed that solubility and dissolution rateof mefenamic acid were distinctively increased in the prepared binary mixture compared tothat of pure mefenamic acid. The increase of dissolution rate was related to the ratio ofmefenacmic acid to chitosan and the method employed.Cogrinding methods (Triturationand ball milling) were the most effective techniques, showing the strongest amorphizingeffect of chitosan. The drug-carrier binary mixtures (Mefenamic acid- chitosan = 1:10 w/w)gave the highest dissolution rate, i.e., about 19.2-fold higher than that of the pure mefenamic acid.

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IJARIIE Mahesh Bhatt, and Chitra Rana. "Enhancement of solubility and dissoulation of a drug Mefenamic acid" International Journal Of Advance Research And Innovative Ideas In Education Volume 8 Issue 6 2022 Page 1523-1530
MLA Mahesh Bhatt, and Chitra Rana. "Enhancement of solubility and dissoulation of a drug Mefenamic acid." International Journal Of Advance Research And Innovative Ideas In Education 8.6(2022) : 1523-1530.
APA Mahesh Bhatt, & Chitra Rana. (2022). Enhancement of solubility and dissoulation of a drug Mefenamic acid. International Journal Of Advance Research And Innovative Ideas In Education, 8(6), 1523-1530.
Chicago Mahesh Bhatt, and Chitra Rana. "Enhancement of solubility and dissoulation of a drug Mefenamic acid." International Journal Of Advance Research And Innovative Ideas In Education 8, no. 6 (2022) : 1523-1530.
Oxford Mahesh Bhatt, and Chitra Rana. 'Enhancement of solubility and dissoulation of a drug Mefenamic acid', International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 6, 2022, p. 1523-1530. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Enhancement_of_solubility_and_dissoulation_of_a_drug_Mefenamic_acid_ijariie18814.pdf (Accessed : ).
Harvard Mahesh Bhatt, and Chitra Rana. (2022) 'Enhancement of solubility and dissoulation of a drug Mefenamic acid', International Journal Of Advance Research And Innovative Ideas In Education, 8(6), pp. 1523-1530IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Enhancement_of_solubility_and_dissoulation_of_a_drug_Mefenamic_acid_ijariie18814.pdf (Accessed : )
IEEE Mahesh Bhatt, and Chitra Rana, "Enhancement of solubility and dissoulation of a drug Mefenamic acid," International Journal Of Advance Research And Innovative Ideas In Education, vol. 8, no. 6, pp. 1523-1530, Nov-Dec 2022. [Online]. Available: https://ijariie.com/AdminUploadPdf/Enhancement_of_solubility_and_dissoulation_of_a_drug_Mefenamic_acid_ijariie18814.pdf [Accessed : ].
Turabian Mahesh Bhatt, and Chitra Rana. "Enhancement of solubility and dissoulation of a drug Mefenamic acid." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 8 number 6 ().
Vancouver Mahesh Bhatt, and Chitra Rana. Enhancement of solubility and dissoulation of a drug Mefenamic acid. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2022 [Cited : ]; 8(6) : 1523-1530. Available from: https://ijariie.com/AdminUploadPdf/Enhancement_of_solubility_and_dissoulation_of_a_drug_Mefenamic_acid_ijariie18814.pdf
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