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Title: :  FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE
PaperId: :  19020
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 1 2023
DUI:    16.0415/IJARIIE-19020
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dharmesh TiwariMillinnium College of Pharmacy, Bhopal
Dr. Nitendra SahuMillinnium College of Pharmacy, Bhopal

Abstract

Pharmacy
Mouth Dissolving Tablet, bioavailability, herbal, Co-Processing, Superdisintegrant
The powdered leaves and flower of Sesbania grandiflora extracted with different solvent. The resultant extract was dried in air until constant weight of the plant extract was obtained. The plant extract was then observed for the physical characteristics. Physically S. grandiflora plant extracts was blackish green in color, bitter in taste and sticky in nature. The solubility analysis of leaves and flower extract of S. grandiflora was performed by using different solvents of variable polarity. The plant extract showed good solubility in variable solvents. The extracted value of S. grandiflora was found to be 15.4. Co-processed superdisintegrants were prepared by solvent evaporation using crospovidone and croscarmellose sodium in different ratios (1:1, 1:2. & 1:3). The co-processed superdisintegrants were evaluated for their flow and compression properties in comparison with physical mixture of superdisintegrants. The angle of repose of co-processed superdisintegrants was found to be <25o which indicate excellent flow in comparison to physical mixture of superdisintegrants (>30o) due to granule formation, Carr’s index in the range of 10-15% and Hausner’s ratio in the range of 1.10-1.14. In vitro disintegration studies on the promising formulation CPF5, control (CFF1) and commercial conventional formulations (CCF) were carried out in pH 6.8 phosphate buffer. From the evaluation parameters, it was observed that 4% co-processed superdisintegrant (1:1 mixture of crospovidone and feugreek seed mucilage) was the optimum concentration for rapid tablet disintegration on the basis of the least disintegration time observed with CPF5 formulation. The superdisintegrant action of Sodium Starch Glycolate resulted in hydrophilicity and swelling which in turn causes rapid disintegration.

Citations

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IJARIIE Dharmesh Tiwari, and Dr. Nitendra Sahu. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 1 2023 Page 447-452
MLA Dharmesh Tiwari, and Dr. Nitendra Sahu. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE." International Journal Of Advance Research And Innovative Ideas In Education 9.1(2023) : 447-452.
APA Dharmesh Tiwari, & Dr. Nitendra Sahu. (2023). FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE. International Journal Of Advance Research And Innovative Ideas In Education, 9(1), 447-452.
Chicago Dharmesh Tiwari, and Dr. Nitendra Sahu. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 1 (2023) : 447-452.
Oxford Dharmesh Tiwari, and Dr. Nitendra Sahu. 'FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 1, 2023, p. 447-452. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_MOUTH_DISSOLVING_TABLET_OF_SESBANIA_GRANDIFLORA_EXTRACT_USING_NOBLE_CO_PROCESS_TECHNIQUE_ijariie19020.pdf (Accessed : ).
Harvard Dharmesh Tiwari, and Dr. Nitendra Sahu. (2023) 'FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE', International Journal Of Advance Research And Innovative Ideas In Education, 9(1), pp. 447-452IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_MOUTH_DISSOLVING_TABLET_OF_SESBANIA_GRANDIFLORA_EXTRACT_USING_NOBLE_CO_PROCESS_TECHNIQUE_ijariie19020.pdf (Accessed : )
IEEE Dharmesh Tiwari, and Dr. Nitendra Sahu, "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 1, pp. 447-452, Jan-Feb 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_MOUTH_DISSOLVING_TABLET_OF_SESBANIA_GRANDIFLORA_EXTRACT_USING_NOBLE_CO_PROCESS_TECHNIQUE_ijariie19020.pdf [Accessed : ].
Turabian Dharmesh Tiwari, and Dr. Nitendra Sahu. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 1 ().
Vancouver Dharmesh Tiwari, and Dr. Nitendra Sahu. FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : ]; 9(1) : 447-452. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_MOUTH_DISSOLVING_TABLET_OF_SESBANIA_GRANDIFLORA_EXTRACT_USING_NOBLE_CO_PROCESS_TECHNIQUE_ijariie19020.pdf
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