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Title: :  FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE
PaperId: :  19484
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 2 2023
DUI:    16.0415/IJARIIE-19484
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Manisha ShahNRI Institute of Pharmaceutical Sciences
Dr. Anjita Singh ThakurNRI Institute of Pharmaceutical Sciences
Dr. Jagdish Chandra RathiNRI Institute of Pharmaceutical Sciences

Abstract

Pharmaceutical
Aceclofenac, microsponges, Preformulation, quasi emulsion, solvent diffusion
The objective of present work was to prepare microsponges of drug aceclofenac. Preformulation testing is the first step in the rational step in the development of dosage forms of a substance. The drug aceclofenac powder was examined for its organoleptic properties found it was observed that it was off white, bitter, crystalline odorless powder. When tested for its solubility in various solvents, it was determined that drug sample was sparingly soluble in water and soluble in 0.1 HCl, methanol, ethanol and Buffer 6.8 pH etc. melting point observed 150-153OC. The partition coefficient was determined as 0.29 ± 0.06. Aceclofenac solution was scanned in the U.V. range of 200-400 nm using systronics, UV Visible spectrophotometer. The spectrophotometric method of analysis of Aceclofenac at max 275.8 nm was found to be reproducible and highly sensitive. The standard curves were prepared in Buffer 6.8 pH at max 275.8nm. The IR spectrum of drug substance was authenticated using FT-IR spectroscopy. Drug and polymer compatibility study reveals that there is no interference between drug and polymer thus can be used for further formulation and evaluation purposes. The microsponges containing Aceclofenac were fabricated by quasi emulsion solvent diffusion method using an inner phase comprising Eudragit S 100 and dibutyl phthalate (1%w/v) dissolved in 7 ml of dichloromethane. Dibutyl phthalate was added to improve the plasticity of the polymer. General parameters of evaluations were observed as Yield (39.66 ± 0.47 to 75.25 ± 0.02), % Drug Content (31.78 ± 0.02 to 45.28 ± 0.01), % Encapsulation Efficiency (91.30 ± 0.04 to 96.56 ± 0.02) and Mean Particle size (98.3 ± 1.02 to 107.6 ± 1.05). SEM Photomicrographs revealed that formulated aceclofenac microsponges were spherical and sponge. In-vitro Release of drug from Aceclofenac microsponges reveals that formulations F-5 and F-6 have release above 90%. Formulated microsponges preparation incorporated in gels in fixed amount. That gel formulations were evaluated and found all formulations were clear, odourless, washable, homogeneous, and free from grittiness and also no phase separation found. Drug stability concerns about drug product safety, efficacy, and quality, found it to appropriate. The percentage drug loss from the formulations was used as a measure of storage stability. It can be concluded that for better stability, the formulations should be stored at low temperature in refrigerator.

Citations

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IJARIIE Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. "FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 2 2023 Page 1016-1024
MLA Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. "FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE." International Journal Of Advance Research And Innovative Ideas In Education 9.2(2023) : 1016-1024.
APA Manisha Shah, Dr. Anjita Singh Thakur, & Dr. Jagdish Chandra Rathi. (2023). FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE. International Journal Of Advance Research And Innovative Ideas In Education, 9(2), 1016-1024.
Chicago Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. "FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 2 (2023) : 1016-1024.
Oxford Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. 'FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 2, 2023, p. 1016-1024. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ACECLOFENAC_LOADED_MICROSPONGE_ijariie19484.pdf (Accessed : 08 May 2023).
Harvard Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. (2023) 'FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE', International Journal Of Advance Research And Innovative Ideas In Education, 9(2), pp. 1016-1024IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ACECLOFENAC_LOADED_MICROSPONGE_ijariie19484.pdf (Accessed : 08 May 2023)
IEEE Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi, "FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 2, pp. 1016-1024, Mar-App 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ACECLOFENAC_LOADED_MICROSPONGE_ijariie19484.pdf [Accessed : 08 May 2023].
Turabian Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. "FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 2 (08 May 2023).
Vancouver Manisha Shah, Dr. Anjita Singh Thakur, and Dr. Jagdish Chandra Rathi. FORMULATION AND EVALUATION OF ACECLOFENAC LOADED MICROSPONGE. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 08 May 2023]; 9(2) : 1016-1024. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION_AND_EVALUATION_OF_ACECLOFENAC_LOADED_MICROSPONGE_ijariie19484.pdf
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