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Title: :  Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model
PaperId: :  20543
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 3 2023
DUI:    16.0415/IJARIIE-20543
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr. Vivek V. PaithankarAmravati, Maharashtra, India
Vaishnavi P. LadhakeAmravati, Maharashtra, India
Mr. Jugalkishor VyasAmravati, Maharashtra, India
Dr. Anjali WankhadeAmravati, Maharashtra, India
Mr. S.D. PandeAmravati, Maharashtra, India

Abstract

Pharmacology
Antidepressant, Actaea racemose, Swiss albino mice.
Background: Mental health has always been a Prime importance along with physical health by the World Health Organization (WHO). Depression contributes to Significant disease burden at global level and is ranked by WHO as the single largest contributor to global disability. Actaea racemosa is known for menopausal properties, hence, this study has been conducted to evaluate the antidepressant activity of Actaea racemosa root extract in rodent models. Materials and Methods: Actaea racemosa root extract was used for evaluating the Antidepressant activity in Swiss Albino Mice. Antidepressant activity was evaluated by comparing with the positive control group by performing Forced swim test and Tail suspension test with Imipramine (10mg/kg) as the standard drug. Reserpine is used as an inducing agent. The Data was analyzed using one way ANOVA (analysis of variance) Followed by Dunnett’s Multiple Comparison Test. P value <0.0001 was considered as statistically significant. Results: Forced swim test and Tail suspension test showed Significant decrease in the period of immobility by Actaea racemosa treated groups indicating its antidepressant property. There is no significant difference observed between the two doses of the extract i.e.; 20mg/kg and 30mg/kg. Conclusion: This study shows that extract of Actaea racemosa root extract possess significant antidepressant properties. The effect produced by the two doses of the test drug was compared with the standard drugs Imipramine and along with the plain control adopting appropriate statistical analysis.

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IJARIIE Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. "Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 3 2023 Page 2741-2746
MLA Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. "Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model." International Journal Of Advance Research And Innovative Ideas In Education 9.3(2023) : 2741-2746.
APA Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, & Mr. S.D. Pande. (2023). Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model. International Journal Of Advance Research And Innovative Ideas In Education, 9(3), 2741-2746.
Chicago Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. "Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 3 (2023) : 2741-2746.
Oxford Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. 'Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 3, 2023, p. 2741-2746. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Evaluation_of_Anti_depressant_Activity_of_Actaea_Racemosa_root_in_Reserpine_induced_experimental_animal_model_ijariie20543.pdf (Accessed : 27 October 2023).
Harvard Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. (2023) 'Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model', International Journal Of Advance Research And Innovative Ideas In Education, 9(3), pp. 2741-2746IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Evaluation_of_Anti_depressant_Activity_of_Actaea_Racemosa_root_in_Reserpine_induced_experimental_animal_model_ijariie20543.pdf (Accessed : 27 October 2023)
IEEE Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande, "Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 3, pp. 2741-2746, May-Jun 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/Evaluation_of_Anti_depressant_Activity_of_Actaea_Racemosa_root_in_Reserpine_induced_experimental_animal_model_ijariie20543.pdf [Accessed : 27 October 2023].
Turabian Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. "Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 3 (27 October 2023).
Vancouver Dr. Vivek V. Paithankar, Vaishnavi P. Ladhake, Mr. Jugalkishor Vyas, Dr. Anjali Wankhade, and Mr. S.D. Pande. Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 27 October 2023]; 9(3) : 2741-2746. Available from: https://ijariie.com/AdminUploadPdf/Evaluation_of_Anti_depressant_Activity_of_Actaea_Racemosa_root_in_Reserpine_induced_experimental_animal_model_ijariie20543.pdf
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