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Title: :  A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH
PaperId: :  20836
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 3 2023
DUI:    16.0415/IJARIIE-20836
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Homeshwari PatodePriyadarshini J. L. College of Pharmacy, Nagpur, India
Dr. A. J. AsnaniPriyadarshini J. L. College of Pharmacy, Nagpur, India

Abstract

Pharmaceutical Chemistry, Biotechnology, Medicinal Chemistry
HPTLC, validation, Paracetamol, Methyl paraben, Propyl paraben, AQbD.
An accurate, simple, rapid and sensitive high performance thin layer chromatographic (HPTLC) method for the determination of paracetamol, Methyl paraben and Propyl paraben was developed and validated in the bulk drug and tablet dosage form by AQbD Approach. Aluminum foil precoated Silica gel G 60F254 plates were used as stationary phase and Toluene: Ethyl acetate: Glacial acetic acid (6.5:2.5:0.5) as mobile phase. Wavelength selected for analysis was 254 nm. The one drug and preservatives were satisfactorily resolved with Rf 0.45± 0.02 for Paracetamol, Rf 0.75 ± 0.05 for Methyl paraben and Rf 0.92 ± 0.05 for Propyl paraben. The method was validated according to ICH guidelines. Linearity was found to be in the concentration range of 100–600 ng/band for Paracetamol and 1-60 ng/band for Methyl paraben and Propyl paraben, respectively. The mean recovery of Paracetamol, Methyl paraben and Propyl paraben was found to be 99.74, 99.56 and 99.51 respectively. Developed HPTLC method was found to be accurate, precise, selective and rapid for simultaneous estimation of Paracetamol, Methyl paraben and Propyl paraben. Thus, it can be used for routine quality control of paracetamol, Methyl paraben and Propyl paraben in various dosage forms.

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IJARIIE Homeshwari Patode, and Dr. A. J. Asnani. "A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 3 2023 Page 4246-4258
MLA Homeshwari Patode, and Dr. A. J. Asnani. "A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH." International Journal Of Advance Research And Innovative Ideas In Education 9.3(2023) : 4246-4258.
APA Homeshwari Patode, & Dr. A. J. Asnani. (2023). A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH. International Journal Of Advance Research And Innovative Ideas In Education, 9(3), 4246-4258.
Chicago Homeshwari Patode, and Dr. A. J. Asnani. "A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 3 (2023) : 4246-4258.
Oxford Homeshwari Patode, and Dr. A. J. Asnani. 'A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 3, 2023, p. 4246-4258. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/A_RESEARCH_ON__DEVELOPMENT_AND_VALIDATION_OF_ANALYTICAL_METHODS_FOR_ESTIMATION_OF_PRESERVATIVES_IN_PHARMACEUTICAL_FORMULATION_BY_AQBD_APPROACH_ijariie20836.pdf (Accessed : 28 June 2023).
Harvard Homeshwari Patode, and Dr. A. J. Asnani. (2023) 'A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH', International Journal Of Advance Research And Innovative Ideas In Education, 9(3), pp. 4246-4258IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/A_RESEARCH_ON__DEVELOPMENT_AND_VALIDATION_OF_ANALYTICAL_METHODS_FOR_ESTIMATION_OF_PRESERVATIVES_IN_PHARMACEUTICAL_FORMULATION_BY_AQBD_APPROACH_ijariie20836.pdf (Accessed : 28 June 2023)
IEEE Homeshwari Patode, and Dr. A. J. Asnani, "A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 3, pp. 4246-4258, May-Jun 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/A_RESEARCH_ON__DEVELOPMENT_AND_VALIDATION_OF_ANALYTICAL_METHODS_FOR_ESTIMATION_OF_PRESERVATIVES_IN_PHARMACEUTICAL_FORMULATION_BY_AQBD_APPROACH_ijariie20836.pdf [Accessed : 28 June 2023].
Turabian Homeshwari Patode, and Dr. A. J. Asnani. "A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 3 (28 June 2023).
Vancouver Homeshwari Patode, and Dr. A. J. Asnani. A RESEARCH ON: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF PRESERVATIVES IN PHARMACEUTICAL FORMULATION BY AQBD APPROACH. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 28 June 2023]; 9(3) : 4246-4258. Available from: https://ijariie.com/AdminUploadPdf/A_RESEARCH_ON__DEVELOPMENT_AND_VALIDATION_OF_ANALYTICAL_METHODS_FOR_ESTIMATION_OF_PRESERVATIVES_IN_PHARMACEUTICAL_FORMULATION_BY_AQBD_APPROACH_ijariie20836.pdf
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