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Title: :  Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance
PaperId: :  21773
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 5 2023
DUI:    16.0415/IJARIIE-21773
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Manan ChandelIEC University
Jyoti GuptaIEC University
HansRaj ChauhanIEC University

Abstract

Pharmacy
fluconazole; nanotransfersome; Box-Behnken design; rheology; permeation; ulcer index
Oral candidiasis is a common fungal infection, with Candida albicans being the causative agent in over 95% of cases. Fluconazole is commonly used to treat oral candidiasis, but conventional oral delivery can cause side effects. This study aimed to develop a fluconazole-loaded sesame oil nanotransfersome formulation (FS-NTF) embedded in hyaluronic acid hydrogel (HA-FS-NTF) to improve localized treatment. An optimal FS-NTF formulation was developed using a Box-Behnken design evaluating the effects of lecithin, fluconazole, and sesame oil amounts on vesicle size, entrapment efficiency, antifungal activity, and ulcer index. The optimized FS-NTF showed 140 nm vesicle size, 70% entrapment efficiency, 14.5 mm fungal inhibition zone, and ulcer index of 1. The HA-FS-NTF exhibited suitable rheological properties for oral delivery. In vitro release was 85% in 3 hours, significantly higher than fluconazole suspension (12%) and gel (43%). Ex vivo permeation across sheep buccal mucosa was also markedly enhanced for HA-FS-NTF (400 μg/cm2) versus gel (294 μg/cm2) and suspension (122 μg/cm2). HA-FS-NTF showed superior antifungal activity with 14.33 mm inhibition zone and ulcer index of 0.67 in rats versus other formulations. Overall, fluconazole delivery is enhanced using nanotransfersomes in hyaluronic acid hydrogel, representing a promising approach for localized oral candidiasis treatment.

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IJARIIE Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. "Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 5 2023 Page 1631-1639
MLA Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. "Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance." International Journal Of Advance Research And Innovative Ideas In Education 9.5(2023) : 1631-1639.
APA Manan Chandel, Jyoti Gupta, & HansRaj Chauhan. (2023). Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance. International Journal Of Advance Research And Innovative Ideas In Education, 9(5), 1631-1639.
Chicago Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. "Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 5 (2023) : 1631-1639.
Oxford Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. 'Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, 2023, p. 1631-1639. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Designed_Gel_Loaded_with_Anti_Fungal_Element_of_Fluconazole_Sesame_Oil_Encapsulated_Nanoparticles__Optimization_and_Analysis_of_Anti_Fungal_Performance_ijariie21773.pdf (Accessed : ).
Harvard Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. (2023) 'Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance', International Journal Of Advance Research And Innovative Ideas In Education, 9(5), pp. 1631-1639IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Designed_Gel_Loaded_with_Anti_Fungal_Element_of_Fluconazole_Sesame_Oil_Encapsulated_Nanoparticles__Optimization_and_Analysis_of_Anti_Fungal_Performance_ijariie21773.pdf (Accessed : )
IEEE Manan Chandel, Jyoti Gupta, and HansRaj Chauhan, "Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, pp. 1631-1639, Sep-Oct 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/Designed_Gel_Loaded_with_Anti_Fungal_Element_of_Fluconazole_Sesame_Oil_Encapsulated_Nanoparticles__Optimization_and_Analysis_of_Anti_Fungal_Performance_ijariie21773.pdf [Accessed : ].
Turabian Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. "Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 5 ().
Vancouver Manan Chandel, Jyoti Gupta, and HansRaj Chauhan. Designed Gel Loaded with Anti-Fungal Element of Fluconazole-Sesame Oil Encapsulated Nanoparticles: Optimization and Analysis of Anti-Fungal Performance. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : ]; 9(5) : 1631-1639. Available from: https://ijariie.com/AdminUploadPdf/Designed_Gel_Loaded_with_Anti_Fungal_Element_of_Fluconazole_Sesame_Oil_Encapsulated_Nanoparticles__Optimization_and_Analysis_of_Anti_Fungal_Performance_ijariie21773.pdf
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