Call for Papers:Vol.11 Issue.3

Submission
Last date		 28-Jun-2025
Acceptance Status In One Day
Paper Publish In Two Days
Submit ManuScript

News & Updates

Submit Article

Dear Authors, Article publish in our journal for Volume-11,Issue-3. For article submission on below link: Submit Manuscript


Join As Board

Dear Reviewer, You can join our Reviewer team without given any charges in our journal. Submit Details on below link: Join As Board


Paper Publication Charges

IJARIIE APP
Download Android App

For Authors

Archives

IJARIIE Board

Downloads

Android App

Download IJARIIE APP

Authors

Title: :  Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder
PaperId: :  21775
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 5 2023
DUI:    16.0415/IJARIIE-21775
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Yatish NegiIEC University
jyotiIEC University
hansrajIEC University
Manan ChandelIEC University

Abstract

Pharmacy
fluconazole; nanotransfersome; Box-Behnken design; rheology; permeation; ulcer index
Oral candidiasis is a common fungal infection, with Candida albicans being the causative agent in over 95% of cases. Fluconazole is commonly used to treat oral candidiasis, but conventional oral delivery can cause side effects. This study aimed to develop a fluconazole-loaded sesame oil nanotransfersome formulation (FS-NTF) embedded in hyaluronic acid hydrogel (HA-FS-NTF) to improve localized treatment. An optimal FS-NTF formulation was developed using a Box-Behnken design evaluating the effects of lecithin, fluconazole, and sesame oil amounts on vesicle size, entrapment efficiency, antifungal activity, and ulcer index. The optimized FS-NTF showed 140 nm vesicle size, 70% entrapment efficiency, 14.5 mm fungal inhibition zone, and ulcer index of 1. The HA-FS-NTF exhibited suitable rheological properties for oral delivery. In vitro release was 85% in 3 hours, significantly higher than fluconazole suspension (12%) and gel (43%). Ex vivo permeation across sheep buccal mucosa was also markedly enhanced for HA-FS-NTF (400 μg/cm2) versus gel (294 μg/cm2) and suspension (122 μg/cm2). HA-FS-NTF showed superior antifungal activity with 14.33 mm inhibition zone and ulcer index of 0.67 in rats versus other formulations. Overall, fluconazole delivery is enhanced using nanotransfersomes in hyaluronic acid hydrogel, representing a promising approach for localized oral candidiasis treatment.

Citations

Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.

IJARIIE Yatish Negi, jyoti, hansraj, and Manan Chandel. "Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 5 2023 Page 1717-1723
MLA Yatish Negi, jyoti, hansraj, and Manan Chandel. "Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder." International Journal Of Advance Research And Innovative Ideas In Education 9.5(2023) : 1717-1723.
APA Yatish Negi, jyoti, hansraj, & Manan Chandel. (2023). Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder. International Journal Of Advance Research And Innovative Ideas In Education, 9(5), 1717-1723.
Chicago Yatish Negi, jyoti, hansraj, and Manan Chandel. "Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 5 (2023) : 1717-1723.
Oxford Yatish Negi, jyoti, hansraj, and Manan Chandel. 'Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, 2023, p. 1717-1723. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Development_and_Evaluation_of_Sublingual_Films_of_Asenapine_for_Management_of_Post_Traumatic_Stress_Disorder_ijariie21775.pdf (Accessed : ).
Harvard Yatish Negi, jyoti, hansraj, and Manan Chandel. (2023) 'Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder', International Journal Of Advance Research And Innovative Ideas In Education, 9(5), pp. 1717-1723IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Development_and_Evaluation_of_Sublingual_Films_of_Asenapine_for_Management_of_Post_Traumatic_Stress_Disorder_ijariie21775.pdf (Accessed : )
IEEE Yatish Negi, jyoti, hansraj, and Manan Chandel, "Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, pp. 1717-1723, Sep-Oct 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/Development_and_Evaluation_of_Sublingual_Films_of_Asenapine_for_Management_of_Post_Traumatic_Stress_Disorder_ijariie21775.pdf [Accessed : ].
Turabian Yatish Negi, jyoti, hansraj, and Manan Chandel. "Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 5 ().
Vancouver Yatish Negi, jyoti, hansraj, and Manan Chandel. Development and Evaluation of Sublingual Films of Asenapine for Management of Post-Traumatic Stress Disorder. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : ]; 9(5) : 1717-1723. Available from: https://ijariie.com/AdminUploadPdf/Development_and_Evaluation_of_Sublingual_Films_of_Asenapine_for_Management_of_Post_Traumatic_Stress_Disorder_ijariie21775.pdf
BibTex EndNote RefMan RefWorks

Number Of Downloads



Save in Google Drive

Similar-Paper

TitleArea of ResearchAuther NameAction
DEVELOPMENT AND EVALUATION OF ENTARIC COATED RABEPARAZOLE SODIUM 50 MG TABLET FOR ENHANCE GASTRO RESISTANCE AND STABILITYPharmacyMr. Saurabh Vitthal Dahatonde Download
FORMULATION & EVALUATION OF ROXITHROMYCIN TABLET FOR RESPIRATORY TRACT INFECTIONPharmacyMr. Abhijeet Kastode Download
Herb drug interactionsPharmaceutical science ( herbal ) Akanksha yadav Download
Phytochemistry and biological evidence on clovePharmaceutical science ( herbal ) Ujjval shukla Download
Antibiotic Resistance in Escherichia coli Isolated from Patients with Urinary Tract InfectionsMicrobiology Ghufran Younus Khairullah ALQARAGULI Download
Analysis of Application-Based Parental Guidance for Children with Psychological DisorderHealth sciences Swetha patil Download
Kidney Transplant Patients, Mutant Patients, and Low-Dose Tacrolimus Therapypharmaceutical KARTAVYA CHETANKUMAR PATEL Download
MANAGEMENT OF MANYASTAMBHA (SPASMODIC TORTICOLLIS / CERVICAL DYSTONIA) THROUGH NASYA KARMA – A CASE STUDYAyurveda Dr. BHAWANA ARUN BIRADE Download
PROFILE OF SEPTIC SHOCK IN A TERTIARY HOSPITAL IN MAURITANIABiological & Medical SciencesMohamed Salem Lehbib Download
CLINICAL PRESENTATION AND PANCHAKARMA APPROACH OF KATI AASHRIT SANDHIGATA VATA (LUMBAR SPONDYLOSIS) – A CASE STUDYAyurvedaVd. Vivek S. Chandurkar Download
Concept Of Sthoulya- A Review ArticleAyurvedaVd. Vivek S Chandurkar Download
AYURVEDIC MANAGEMENT OF JALODARA ; A CASE STUDYAyurvedaDr. Vivek S. Chandurkar Download
The Role of Artificial Intelligence in health sectorArtificial intelligenceMusala Pravallika Download
Effect of Gabapentin, Amitriptyline and Pregabalin in Neurological, Sciatica and Orthopaedic Backpain PatientsMedicalBhupesh Bhardwaj Download
HPLC METHOD DEVELOPMENT AND VALIDATION: A REVIEWPharmacy VISHAL NILKANTHRAO CHAVAN Download
12