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Title: :  Comparison Of Dissolution study and of commercially available paracetamol tablets
PaperId: :  21887
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 5 2023
DUI:    16.0415/IJARIIE-21887
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Prof. Prateek JainNRI Institute of Pharmaceutical Sciences Bhopal
Sonam VermaNRI Institute of Pharmaceutical Sciences Bhopal
Saurabh SahuNRI Institute of Pharmaceutical Sciences Bhopal
Sumit Barothiya NRI Institute of Pharmaceutical Sciences Bhopal
Shreya VermaNRI Institute of Pharmaceutical Sciences Bhopal
Sudhir Kumar KeshriNRI Institute of Pharmaceutical Sciences Bhopal
Dr. Jagdish RathiNRI Institute of Pharmaceutical Sciences Bhopal

Abstract

Bechlor in Pharmacy
Keyword:-Physical Property,Chemical Property,Solubility,Paracetamol,(NSAIDs)
ABSTRACT Oral dosage form like tablets, capsules, suspensions etc is one of the most common method used for the administration of drug.. Among all, tablets are more widely used being tempered free, cost effective, and stable. In formulation systems, manufacturing process and rawmaterials used affectsthe qualityof finished product. Itis very much essential to determine the parameters of tablets to ensure the quality of the product. Quality is the most important issue in the pharmaceutical field due to the presence of a drug which is considered as safe and therapeutically active agent.In-vitroevaluationensurestheirquality,bioavailabilityaswell asoptimumtherapeutic activity. Paracetamol (acetaminophen) which are the active metabolites of phenacetin is commonly used for the relief of headaches and pains, and is a major ingredient in numerous cold and flu remedies. Paracetamols are available in different brands in Indian market. The main objective of the present study was to conduct the comparative in-vitro dissolution studies of various brands collected from the local market to determine whether all the formulations used were equivalent or significantly different. The calibration curve was constructed covering the concentration range of 1 to 10 mcg/ml at 268 nm by UV spectrophotometer (UV 2203 Double beam spectrophotometer, Shimadzu). Five different brands of Paracetamol of 500 mg conventional tablets from different manufacturers were selected in the study and dissolution testing in Phosphate buffer at pH 7.4 was conducted from each brands for 90 mins by using dissolution testing apparatus USP type-ll. The dissolution rate was subjected to various mathematical models like zero order, first order, Higuchi and Hixson-Crowell equations to elucidate the kinetic behavior of drug release from the test samples. Different release kinetics model of all the selected brandswas assuring the quality standard of manufacturing.

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IJARIIE Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. "Comparison Of Dissolution study and of commercially available paracetamol tablets" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 5 2023 Page 2548-2551
MLA Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. "Comparison Of Dissolution study and of commercially available paracetamol tablets." International Journal Of Advance Research And Innovative Ideas In Education 9.5(2023) : 2548-2551.
APA Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, & Dr. Jagdish Rathi. (2023). Comparison Of Dissolution study and of commercially available paracetamol tablets. International Journal Of Advance Research And Innovative Ideas In Education, 9(5), 2548-2551.
Chicago Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. "Comparison Of Dissolution study and of commercially available paracetamol tablets." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 5 (2023) : 2548-2551.
Oxford Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. 'Comparison Of Dissolution study and of commercially available paracetamol tablets', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, 2023, p. 2548-2551. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Comparison_Of_Dissolution_study_and_of_commercially_available_paracetamol_tablets_ijariie21887.pdf (Accessed : ).
Harvard Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. (2023) 'Comparison Of Dissolution study and of commercially available paracetamol tablets', International Journal Of Advance Research And Innovative Ideas In Education, 9(5), pp. 2548-2551IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Comparison_Of_Dissolution_study_and_of_commercially_available_paracetamol_tablets_ijariie21887.pdf (Accessed : )
IEEE Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi, "Comparison Of Dissolution study and of commercially available paracetamol tablets," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, pp. 2548-2551, Sep-Oct 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/Comparison_Of_Dissolution_study_and_of_commercially_available_paracetamol_tablets_ijariie21887.pdf [Accessed : ].
Turabian Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. "Comparison Of Dissolution study and of commercially available paracetamol tablets." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 5 ().
Vancouver Prof. Prateek Jain, Sonam Verma, Saurabh Sahu, Sumit Barothiya , Shreya Verma, Sudhir Kumar Keshri, and Dr. Jagdish Rathi. Comparison Of Dissolution study and of commercially available paracetamol tablets. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : ]; 9(5) : 2548-2551. Available from: https://ijariie.com/AdminUploadPdf/Comparison_Of_Dissolution_study_and_of_commercially_available_paracetamol_tablets_ijariie21887.pdf
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