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Title: :  Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report
PaperId: :  22358
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 6 2023
DUI:    16.0415/IJARIIE-22358
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Muhammad AlguthfaniDepartment of Internal Medicine, Sumber Hurip Hospital
Raka Jaiz Fauzan PinilihDepartment of Internal Medicine, Sumber Hurip Hospital

Abstract

Healthcare Management, Medical Science
Wegener’s granulomatosis, nasopharyngeal biopsies, vascular dilatation, bleeding
Wegener's granulomatosis, or granulomatosis with polyangiitis (GPA), presents a diagnostic and therapeutic challenge due to its diverse clinical manifestations. In a recent case encountered in our Emergency Department (ED), a 20-year-old female presented with a distressing seven-day history of severe odynophagia, rendering her unable to consume both solids and liquids due to the intensity of pain. This alarming symptomatology was accompanied by painful swellings over the outer part of both eyes, indicating potential ocular involvement, a recognized aspect of Wegener's granulomatosis. Further investigation revealed a positive cytoplasmic antinuclear antibody (c-ANCA) at a titre of 1:160, a pivotal immunological marker contributing to the diagnostic confirmation of the underlying autoimmune process. Nasopharyngeal biopsies undertaken in this case exhibited characteristic findings, including fibrinoid necrosis with inflammatory cell infiltration, alongside vascular abnormalities such as dilatation and bleeding. These histopathological insights into the disease's impact on the upper respiratory tract emphasized the multisystemic nature of Wegener's granulomatosis, reinforcing the need for a comprehensive and multidisciplinary approach to diagnosis and management. This clinical scenario underscores the importance of recognizing odynophagia as a potential indicator of disease activity in Wegener's granulomatosis. The integration of clinical, immunological, and histopathological findings is paramount in elucidating the complex nature of this autoimmune disorder. The positive c-ANCA titre and characteristic biopsy results provide critical information guiding appropriate therapeutic interventions and highlighting the need for vigilant monitoring of the patient's multisystem involvement. This case not only contributes to our understanding of the diverse presentations of Wegener's granulomatosis but also underscores the significance of a holistic approach in managing the complexities associated with this challenging autoimmune condition.

Citations

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IJARIIE Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. "Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 6 2023 Page 2579-2583
MLA Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. "Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report." International Journal Of Advance Research And Innovative Ideas In Education 9.6(2023) : 2579-2583.
APA Muhammad Alguthfani, & Raka Jaiz Fauzan Pinilih. (2023). Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report. International Journal Of Advance Research And Innovative Ideas In Education, 9(6), 2579-2583.
Chicago Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. "Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 6 (2023) : 2579-2583.
Oxford Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. 'Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 6, 2023, p. 2579-2583. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Wegener_s_Granulomatosis_in_A_20_Years_Old_Woman_Presenting_with_Severe_Odynophagia__and_Recurent_Eye_Complaints__A_Rare_Case_Report_ijariie22358.pdf (Accessed : 02 January 2024).
Harvard Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. (2023) 'Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report', International Journal Of Advance Research And Innovative Ideas In Education, 9(6), pp. 2579-2583IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Wegener_s_Granulomatosis_in_A_20_Years_Old_Woman_Presenting_with_Severe_Odynophagia__and_Recurent_Eye_Complaints__A_Rare_Case_Report_ijariie22358.pdf (Accessed : 02 January 2024)
IEEE Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih, "Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 6, pp. 2579-2583, Nov-Dec 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/Wegener_s_Granulomatosis_in_A_20_Years_Old_Woman_Presenting_with_Severe_Odynophagia__and_Recurent_Eye_Complaints__A_Rare_Case_Report_ijariie22358.pdf [Accessed : 02 January 2024].
Turabian Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. "Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 6 (02 January 2024).
Vancouver Muhammad Alguthfani, and Raka Jaiz Fauzan Pinilih. Wegener's Granulomatosis in A 20-Years-Old Woman Presenting with Severe Odynophagia, and Recurent Eye Complaints: A Rare Case Report. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 02 January 2024]; 9(6) : 2579-2583. Available from: https://ijariie.com/AdminUploadPdf/Wegener_s_Granulomatosis_in_A_20_Years_Old_Woman_Presenting_with_Severe_Odynophagia__and_Recurent_Eye_Complaints__A_Rare_Case_Report_ijariie22358.pdf
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