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Title: :  Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model
PaperId: :  23242
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 2 2024
DUI:    16.0415/IJARIIE-23242
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Praful G Rajpurohit1PG Scholar, College of Pharmacy, Dr. A.P. J. Abdul Kalam University, Indore.
Dr. Rajendra Bapna22Associate Professor, College of Pharmacy
Ragini Bundela22Associate Professor, College of Pharmacy
Dr. Karunakar Shukla33Professor and Principal, College of Pharmacy, Dr. A.P. J. Abdul Kalam University, Indore. .

Abstract

Pharmacy
Phloretin, Cisplatin, Nephrotoxicity, Peri-menopause
Cisplatin is an effective on cancer like prostate cancer, bladder cancer, overian cancer, lung cancer that causes remarkable toxicity to the kidney, particularly to glomerular filter, by generating reactive oxygen species. From literature it is evident that women are more prone to Cisplatin induced nephrotoxicity, and the women >45 yrs of age are more prone to cisplatin induced nephrotoxicity. More specifically women of 45-55 age group (peri-menopausal age) are more prone for cisplatin induced nephrotoxicity. It has also become evident that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction.In the Cisplatin induced nephrotoxicity study in perimenopausal mouse model, Cisplatin treated group significantly increased level of serum creatinine, BUN, ALP and decreased the level of albumin. Cisplatin treated mice the decrease the level of GSH, SOD and increased the level of LPO. Cisplatin treated animals shows the damaged to the kidney. Phloretin shows the significant protective effect in kidney function parameters (CRE, BUN and albumin in serum), oxidative stress parameters and microscopic tissue injury in histopathology studies. While the phloretin treatment with low and high-dose (20–60 mg/kg) was possessed the significant protective effects against the cisplatin-induced renal damage, more importantly it also increased survival and delayed mortality in cisplatin treated perimenopausal mice model. The observed results of the current research work clearly exhibited the clinical potential of phloretin as cotreatment with cisplatin for cancer treatment in perimenopausal women to reduce cisplatin induced nephrotoxicity.

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IJARIIE Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. "Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 2 2024 Page 3413-3428
MLA Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. "Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model." International Journal Of Advance Research And Innovative Ideas In Education 10.2(2024) : 3413-3428.
APA Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, & Dr. Karunakar Shukla3. (2024). Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model. International Journal Of Advance Research And Innovative Ideas In Education, 10(2), 3413-3428.
Chicago Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. "Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 2 (2024) : 3413-3428.
Oxford Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. 'Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 2, 2024, p. 3413-3428. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Preclinical_evaluation_of_phloretin_on_cisplatin_induced_nephrotoxicity_in_peri_menopausal_mouse_model_ijariie23242.pdf (Accessed : ).
Harvard Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. (2024) 'Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model', International Journal Of Advance Research And Innovative Ideas In Education, 10(2), pp. 3413-3428IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Preclinical_evaluation_of_phloretin_on_cisplatin_induced_nephrotoxicity_in_peri_menopausal_mouse_model_ijariie23242.pdf (Accessed : )
IEEE Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3, "Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 2, pp. 3413-3428, Mar-App 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/Preclinical_evaluation_of_phloretin_on_cisplatin_induced_nephrotoxicity_in_peri_menopausal_mouse_model_ijariie23242.pdf [Accessed : ].
Turabian Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. "Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 2 ().
Vancouver Praful G Rajpurohit, Dr. Rajendra Bapna2, Ragini Bundela2, and Dr. Karunakar Shukla3. Preclinical evaluation of phloretin on cisplatin induced nephrotoxicity in peri-menopausal mouse model. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : ]; 10(2) : 3413-3428. Available from: https://ijariie.com/AdminUploadPdf/Preclinical_evaluation_of_phloretin_on_cisplatin_induced_nephrotoxicity_in_peri_menopausal_mouse_model_ijariie23242.pdf
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