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Title: :  IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION
PaperId: :  23737
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 3 2024
DUI:    16.0415/IJARIIE-23737
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Prerana D. KalyankarShivajirao Pawar College of Pharmacy, Pachegaon
Dr. Megha T. Salve Shivajirao Pawar College of Pharmacy, Pachegaon

Abstract

Pharmacy
Schiff base, Dihydrofolate reductase Inhibition, Molecular Docking, ADME Prediction, Antibacterial activity.
Schiff base-containing (imine or azomethine–C=N–) derivatives have been investigated in relation to a broad range of activity, including antibacterial activity, antiviral activity, anticancer activity, polymer technology and in many other areas due to the presence of moiety in their structures. Antibacterial activity of Schiff bases can achieve by various enzyme inhibitory mechanism. Primary target for the antibacterial drugs is inhibiting dihydrofolate Reductase (DHFR) enzyme which result in inhibition of bacterial folate synthesis and act as bactericidal. In this research article pharmacokinetic properties, bioactivity score, in silico docking studies and toxicity prediction of 10 Schiff base compounds i.e. SB1, SB2, SB3, SB4, SB5, SB6, SB7, SB8, SB9, and SB10 were carried out against dihydrofolate Reductase enzyme (1Mvt) was examined and possible probability were recorded.

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IJARIIE Prerana D. Kalyankar, and Dr. Megha T. Salve . "IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 3 2024 Page 5030-5044
MLA Prerana D. Kalyankar, and Dr. Megha T. Salve . "IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION." International Journal Of Advance Research And Innovative Ideas In Education 10.3(2024) : 5030-5044.
APA Prerana D. Kalyankar, & Dr. Megha T. Salve . (2024). IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION. International Journal Of Advance Research And Innovative Ideas In Education, 10(3), 5030-5044.
Chicago Prerana D. Kalyankar, and Dr. Megha T. Salve . "IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 3 (2024) : 5030-5044.
Oxford Prerana D. Kalyankar, and Dr. Megha T. Salve . 'IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 3, 2024, p. 5030-5044. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/IN_SILICO_DOCKING_AND_ADMET_PREDICTION_OF_A_NOVEL_ANTIBACTERIAL_DERIVATIVES__SCHIFF_BASE__FOR_DIHYDROFOLATE_REDUCTASE__1MVT__INHIBITION_ijariie23737.pdf (Accessed : 22 February 2025).
Harvard Prerana D. Kalyankar, and Dr. Megha T. Salve . (2024) 'IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION', International Journal Of Advance Research And Innovative Ideas In Education, 10(3), pp. 5030-5044IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/IN_SILICO_DOCKING_AND_ADMET_PREDICTION_OF_A_NOVEL_ANTIBACTERIAL_DERIVATIVES__SCHIFF_BASE__FOR_DIHYDROFOLATE_REDUCTASE__1MVT__INHIBITION_ijariie23737.pdf (Accessed : 22 February 2025)
IEEE Prerana D. Kalyankar, and Dr. Megha T. Salve , "IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 3, pp. 5030-5044, May-Jun 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/IN_SILICO_DOCKING_AND_ADMET_PREDICTION_OF_A_NOVEL_ANTIBACTERIAL_DERIVATIVES__SCHIFF_BASE__FOR_DIHYDROFOLATE_REDUCTASE__1MVT__INHIBITION_ijariie23737.pdf [Accessed : 22 February 2025].
Turabian Prerana D. Kalyankar, and Dr. Megha T. Salve . "IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 3 (22 February 2025).
Vancouver Prerana D. Kalyankar, and Dr. Megha T. Salve . IN SILICO DOCKING AND ADMET PREDICTION OF A NOVEL ANTIBACTERIAL DERIVATIVES (SCHIFF BASE) FOR DIHYDROFOLATE REDUCTASE (1MVT) INHIBITION. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : 22 February 2025]; 10(3) : 5030-5044. Available from: https://ijariie.com/AdminUploadPdf/IN_SILICO_DOCKING_AND_ADMET_PREDICTION_OF_A_NOVEL_ANTIBACTERIAL_DERIVATIVES__SCHIFF_BASE__FOR_DIHYDROFOLATE_REDUCTASE__1MVT__INHIBITION_ijariie23737.pdf
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