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Title: :  “FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”
PaperId: :  24290
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 3 2024
DUI:    16.0415/IJARIIE-24290
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mohan Sahebrao Salunke RKDF College of Pharmacy
Ankita ChaurasiaRKDF College of Pharmacy
Dr. G. Pawan KumarRKDF College of Pharmacy
Dr. S. MandalRKDF College of Pharmacy

Abstract

Pharmaceutical
Formulation of floting Matrix tablet
The aim of present study is The stomach and upper part of the small intestine are where furosemide is primarily absorbed when treating edema brought on by congestive heart failure (CHF), hepatic cirrhosis, renal impairment, and nephrotic syndrome. This narrow absorption window is responsible for furosemide’s limited oral bioavailability. Floating matrix tablet were prepared by direct compression technique using different Polymer with varying concentration. all polymer and drug were passed through sieve no.80 separately. Then drug were mixed in polybag for 5 min with the polymers and other ingredients in weight proportion as mentioned in Table 13. The powder blend was then lubricated with magnesium stearate and talc, and this lubricated blend were compressed into tablets using 8-mm flat-face on a 16 stationary rotary punching tablet machine with hardness in range of 5 to 5.5 kg/cm2. HPMC K4M and HPMC K100LV have predominant effect on drug release. HPMC K4M gives the good matrix integrity and retained drug release. HPMC K100LV along with HPMC K4M provides sustained and controlled drug release over the expected period of time. Sodium bicarbonate has predominant effect on the buoyancy lag time and also shows significant effect on drug release. In-vitro release rate studies showed that the minimum drug release was observed

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IJARIIE Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. "“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 3 2024 Page 5217-5230
MLA Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. "“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”." International Journal Of Advance Research And Innovative Ideas In Education 10.3(2024) : 5217-5230.
APA Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, & Dr. S. Mandal. (2024). “FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”. International Journal Of Advance Research And Innovative Ideas In Education, 10(3), 5217-5230.
Chicago Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. "“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 3 (2024) : 5217-5230.
Oxford Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. '“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 3, 2024, p. 5217-5230. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/“FORMULATION_AND_IN_VITRO_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_FUROSEMIDE_FOR_ORAL_CONTROLLED_RELEASE”_ijariie24290.pdf (Accessed : ).
Harvard Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. (2024) '“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”', International Journal Of Advance Research And Innovative Ideas In Education, 10(3), pp. 5217-5230IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/“FORMULATION_AND_IN_VITRO_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_FUROSEMIDE_FOR_ORAL_CONTROLLED_RELEASE”_ijariie24290.pdf (Accessed : )
IEEE Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal, "“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 3, pp. 5217-5230, May-Jun 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/“FORMULATION_AND_IN_VITRO_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_FUROSEMIDE_FOR_ORAL_CONTROLLED_RELEASE”_ijariie24290.pdf [Accessed : ].
Turabian Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. "“FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 3 ().
Vancouver Mohan Sahebrao Salunke , Ankita Chaurasia, Dr. G. Pawan Kumar, and Dr. S. Mandal. “FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLET OF FUROSEMIDE FOR ORAL CONTROLLED RELEASE”. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : ]; 10(3) : 5217-5230. Available from: https://ijariie.com/AdminUploadPdf/“FORMULATION_AND_IN_VITRO_EVALUATION_OF_FLOATING_MATRIX_TABLET_OF_FUROSEMIDE_FOR_ORAL_CONTROLLED_RELEASE”_ijariie24290.pdf
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