Call for Papers:Vol.10 Issue.6

Submission
Last date		 30-Dec-2024
Acceptance Status In One Day
Paper Publish In Two Days
Submit ManuScript

News & Updates

Submit Article

Dear Authors, Article publish in our journal for Volume-10,Issue-6. For article submission on below link: Submit Manuscript


Join As Board

Dear Reviewer, You can join our Reviewer team without given any charges in our journal. Submit Details on below link: Join As Board


Paper Publication Charges

IJARIIE APP
Download Android App

For Authors

Archives

IJARIIE Board

Downloads

Android App

Download IJARIIE APP

Authors

Title: :  HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.
PaperId: :  24448
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 4 2024
DUI:    16.0415/IJARIIE-24448
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Rakshitha SBharathi College of Pharmacy, Bharathinagara
Suresha B SBharathi College of Pharmacy, Bharathinagara
Meghana B PBharathi College of Pharmacy, Bharathinagara
Balasubramanian TBharathi College of Pharmacy, Bharathinagara

Abstract

Pharmacology
Hepatoprotective activity, Sauropus androgynous, Paracetamol, Ethanol, Hepatic injury.
The hepatoprotective activity of ethanolic extract of the leaves of Sauropus androgynous was investigated for paracetamol and ethanol induced hepatotoxicity in rats. Wistar albino rats were divided into five groups of 6 animals each and are given orally with the following treatment for 10 and 21 days respectively. The Normal control group was given 0.3% starch solution 1 ml/kg b.w, Paracetamol at a dose of 2 g/kg b.w, p.o, and 30% Ethanol at a dose of 1 ml/100 g b.w, was given for inducing hepatotoxicity. Silymarin (50 mg/kg, p.o.) was given as reference standard for both the methods. Two doses of S. androgynous leaves extract i.e., 200 and 400 mg/kg p.o. was tested for hepatoprotective activity. The treatment was given for 10 days in Paracetamol induced hepatotoxicity and 21 days for Ethanol induced hepatotoxicity model. After 24 h of last treatment blood was collected by cardiac puncture and analysed for various serum parameters like serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), total protein (TP) and total bilirubin (TB) in different groups. In both the methods, ethanolic extract of Sauropus androgynous showed dose dependent significant decrease in SGPT, SGOT, ALP, total bilirubin and increase in total protein levels. Hepatoprotective effect was also confirmed by histopathological studies of liver which showed less damage in extract treated groups when compared with Paracetamol (2 g/kg) and 30% Ethanol (1 ml/100g). The extract found to have significant hepatoprotective activity in both Paracetamol and Ethanol induced hepatic injury models.

Citations

Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.

IJARIIE Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. "HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS." International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 4 2024 Page 136-145
MLA Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. "HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.." International Journal Of Advance Research And Innovative Ideas In Education 10.4(2024) : 136-145.
APA Rakshitha S, Suresha B S, Meghana B P, & Balasubramanian T. (2024). HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.. International Journal Of Advance Research And Innovative Ideas In Education, 10(4), 136-145.
Chicago Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. "HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 4 (2024) : 136-145.
Oxford Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. 'HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 4, 2024, p. 136-145. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/HEPATOPROTECTIVE_ACTIVITY_OF_SAUROPUS_ANDROGYNOUS_LEAVES_AGAINST_PARACETAMOL_AND_ETHANOL_INDUCED_HEPATOTOXICITY_IN_RATS__ijariie24448.pdf (Accessed : ).
Harvard Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. (2024) 'HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.', International Journal Of Advance Research And Innovative Ideas In Education, 10(4), pp. 136-145IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/HEPATOPROTECTIVE_ACTIVITY_OF_SAUROPUS_ANDROGYNOUS_LEAVES_AGAINST_PARACETAMOL_AND_ETHANOL_INDUCED_HEPATOTOXICITY_IN_RATS__ijariie24448.pdf (Accessed : )
IEEE Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T, "HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 4, pp. 136-145, Jul-Aug 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/HEPATOPROTECTIVE_ACTIVITY_OF_SAUROPUS_ANDROGYNOUS_LEAVES_AGAINST_PARACETAMOL_AND_ETHANOL_INDUCED_HEPATOTOXICITY_IN_RATS__ijariie24448.pdf [Accessed : ].
Turabian Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. "HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 4 ().
Vancouver Rakshitha S, Suresha B S, Meghana B P, and Balasubramanian T. HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : ]; 10(4) : 136-145. Available from: https://ijariie.com/AdminUploadPdf/HEPATOPROTECTIVE_ACTIVITY_OF_SAUROPUS_ANDROGYNOUS_LEAVES_AGAINST_PARACETAMOL_AND_ETHANOL_INDUCED_HEPATOTOXICITY_IN_RATS__ijariie24448.pdf
BibTex EndNote RefMan RefWorks

Number Of Downloads



Save in Google Drive

Similar-Paper

TitleArea of ResearchAuther NameAction
REVIEW ON A FORMULATION, EVALUATION PARAMETERS OF HERBAL PARAMETERS OF HERBAL TOOTH POWDER BY USING HERBAL DRUGSPharmacyPawar Sakshi.N Download
“Bacteriophage Therapy: A Promising Solution to Combat Antibiotic Resistance”PharmacyRutuja Ashok Shelke Download
Therapeutic Potential of Bacopa monnieri in Kindling-Induced Post-Ictal Depression: A Comprehensive ReviewPharmaceutical ScienceSonali B. Kolape Download
Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A ReviewPharmaceutical SciencePrerana S. Koke Download
Green Chemistry: Intent, Result, and PrinciplesPharmacyMr. Govinda L. Tarange Download
Covid-19 Pandemic: Viral Pathogenesis, Clinical Manifestation, Diagnostic, Evaluation and ManagementPharmacology Akshay Chaudhary Download
A SYSTEMIC REVIEW ON MEDICAL TREATMENT OF ATOPIC DERMATITIS (ECZEMA)Medical EducationMonika Devi Download
Navigating the Intersection of COVID-19 and Avascular Necrosis: Challenges and Opportunities for Patient ManagementPharamaceutical educationHARSHAL GAJANAN DESALE Download
Drug Development and Hepatotoxicity: A Comprehensive Exploration of Medical AdvancementM. Pharmacy (Pharmacology)Laxmipriya Nayak Download
PHYTOCHEMICAL SCREENING OF POD EXTRACT OF MORINGA OLEIFERABiological and Medical SciencesU.S. Khandekar Download
HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.PharmacologyRakshitha S Download
IMPACT OF MANDUKASANA AND MATSYENDRASANA ON DIABETES- A RESEARCH ARTICLENishant K. MishraNishant K. Mishra Download
The Brief Review Mucoadhesive Drug Delivery SystemPharmacyMs. Shruti Satish Garad Download
Review of bioassayPharmacyPiyusha Satish Patange Download
FORMULATION AND EVALUATION OF BLUSH PREPARATION BY USING NATURAL COLORING FROM RED BEETROOT POWDERPharmaceuticsBushra S.Sayyed Download
12