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Title: :  PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY
PaperId: :  25283
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 6 2024
DUI:    16.0415/IJARIIE-25283
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr Parimal KoiralaDepartment of Internal Medicine, National Academy of Medical Sciences, Bir-Hospital, Kathmandu, Nepal
Dr Binod PanthaDepartment of Internal Medicine, National Academy of Medical Sciences, Bir-Hospital, Kathmandu, Nepal
Dr Milan KhadkaDepartment of Internal Medicine, National Academy of Medical Sciences, Bir-Hospital, Kathmandu, Nepal
Dr Lochan KarkiDepartment of Internal Medicine, National Academy of Medical Sciences, Bir-Hospital, Kathmandu, Nepal
Dr Prasanna Amatya5Department of Cardiology, National Academy of Medical Sciences, Bir-Hospital, Kathmandu, Nepal

Abstract

MEDICAL SCIENCES.INTERNAL MEDICINE
Diabetes mellitus, chronic liver disease, Child Pugh score
Background Diabetes Mellitus (DM) is a complex metabolic condition defined by the level of hyperglycemia giving rise to risk of micro vascular or macro vascular complications. DM is associated with reduced life expectancy and significant morbidity due to micro or macro vascular complications and impaired quality of life. Diabetes develops from an imbalance between insulin sensitivity and insulin secretion. The liver plays a key role in the whole-body response to insulin. The prevalence of diabetes is higher in patients who have certain liver diseases. There is a link between the presence of diabetes and the severity of liver injury. On analysis of various studies, it is important to remember the link between diabetes and cirrhosis, because studies with an increased proportion of cirrhotic patients are more likely to find an association between diabetes and disease severity. The liver diseases associated with diabetes include nonalcoholic fatty liver disease, chronic viral hepatitis, hemochromatosis, alcoholic liver disease, and cirrhosis. Objectives The objective of this study is to determine the prevalence of diabetes in patients with CLD. Methods This is a cross-sectional study. The study analyzed 48 patients with liver diseases. All the patients with cirrhosis of either gender fulfilling the inclusion criteria were enrolled in the study. Ethical approval was obtained. Laboratory parameters like, platelet count,fasting and post-prandial sugar, HbA1C,ultrasonography of abdomen, and upper gastro-intestinal tract endoscopy, prothrombin time, serum bilirubin, albumin were measured.Child Pugh Scores was calculated by adding the scores of the five factors (serum bilirubin, serum albumin, prothrombin time, grade of ascites and hepatic encephalopathy). Data entry was done in SPSS version 20 and statistical analysis was done with Chi Square test. Results Total 48 patients were enrolled in the test. DM was present in 10 (20.8%) of the CLD patients. The frequency of DM in CLD patients was highest in chronic hepatitis C related liver cirrhosis i.e.3 patients (30%) and the result was statistically significant with the p value of <0.00001. Child Pugh score C had highest frequency for DM occurrence i.e. 9(18.75%) than child pugh A and B but this result was not statistically significant with p value 0.53. Conclusions The prevalence of diabetes was highest in chronic hepatitis C related liver cirrhosis. As the severity of liver disease increases, higher chances of DM occurrence. Keywords Diabetes mellitus, chronic liver disease, Child Pugh score

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IJARIIE Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. "PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 6 2024 Page 151-157
MLA Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. "PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY." International Journal Of Advance Research And Innovative Ideas In Education 10.6(2024) : 151-157.
APA Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, & Dr Prasanna Amatya. (2024). PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY. International Journal Of Advance Research And Innovative Ideas In Education, 10(6), 151-157.
Chicago Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. "PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 6 (2024) : 151-157.
Oxford Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. 'PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, 2024, p. 151-157. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/PREVALENCE_OF_DIABETES_IN_CHRONIC_LIVER_DISEASE_PATIENTS__A_CROSS_SECTIONAL_STUDY_ijariie25283.pdf (Accessed : ).
Harvard Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. (2024) 'PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY', International Journal Of Advance Research And Innovative Ideas In Education, 10(6), pp. 151-157IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/PREVALENCE_OF_DIABETES_IN_CHRONIC_LIVER_DISEASE_PATIENTS__A_CROSS_SECTIONAL_STUDY_ijariie25283.pdf (Accessed : )
IEEE Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya, "PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, pp. 151-157, Nov-Dec 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/PREVALENCE_OF_DIABETES_IN_CHRONIC_LIVER_DISEASE_PATIENTS__A_CROSS_SECTIONAL_STUDY_ijariie25283.pdf [Accessed : ].
Turabian Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. "PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 6 ().
Vancouver Dr Parimal Koirala, Dr Binod Pantha, Dr Milan Khadka, Dr Lochan Karki, and Dr Prasanna Amatya. PREVALENCE OF DIABETES IN CHRONIC LIVER DISEASE PATIENTS: A CROSS-SECTIONAL STUDY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : ]; 10(6) : 151-157. Available from: https://ijariie.com/AdminUploadPdf/PREVALENCE_OF_DIABETES_IN_CHRONIC_LIVER_DISEASE_PATIENTS__A_CROSS_SECTIONAL_STUDY_ijariie25283.pdf
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