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Title: :  Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review
PaperId: :  25312
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 6 2024
DUI:    16.0415/IJARIIE-25312
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Prerana S. KokeLoknete shri Dadapatil Pharate college of pharmacy, Mandavgan pharata, Pune

Abstract

Pharmaceutical Science
Acacetin, Cardiac Hypertrophy, Natural Flavonoid, Cardioprotection, Isoproterenol.
Cardiac hypertrophy, a pathological response to prolonged stress or injury, is a critical precursor to heart failure and other severe cardiovascular conditions. Experimental models using isoproterenol (ISO), a beta-adrenergic agonist, replicate many aspects of human cardiac hypertrophy, making it valuable for studying potential therapies. Acacetin, a flavonoid derived from several medicinal plants, has gained attention for its broad pharmacological actions, including antioxidant, anti-inflammatory, and anti-apoptotic effects. This review examines the therapeutic potential of acacetin in ISO-induced cardiac hypertrophy, exploring its molecular mechanisms and cardioprotective actions. Key findings from preclinical studies demonstrate that acacetin alleviates oxidative stress, reduces inflammation, and regulates calcium homeostasis, effectively mitigating cellular hypertrophy, fibrosis, and apoptosis in cardiac cells. By targeting multiple pathways—such as NF-κB, PI3K/Akt/mTOR, and MAPK—acacetin presents a comprehensive approach to preventing hypertrophy and promoting cardiac health. This review underscores the promise of acacetin as a potential therapeutic agent and highlights the need for clinical studies to confirm its efficacy and safety in cardiovascular disease management.

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IJARIIE Prerana S. Koke. "Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 6 2024 Page 404-415
MLA Prerana S. Koke. "Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review." International Journal Of Advance Research And Innovative Ideas In Education 10.6(2024) : 404-415.
APA Prerana S. Koke. (2024). Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review. International Journal Of Advance Research And Innovative Ideas In Education, 10(6), 404-415.
Chicago Prerana S. Koke. "Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 6 (2024) : 404-415.
Oxford Prerana S. Koke. 'Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, 2024, p. 404-415. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Pharmacological_Evaluation_of_Acacetin_Against_Isoproterenol_Induced_Cardiac_Hypertrophy__A_Review_ijariie25312.pdf (Accessed : 16 November 2024).
Harvard Prerana S. Koke. (2024) 'Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review', International Journal Of Advance Research And Innovative Ideas In Education, 10(6), pp. 404-415IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Pharmacological_Evaluation_of_Acacetin_Against_Isoproterenol_Induced_Cardiac_Hypertrophy__A_Review_ijariie25312.pdf (Accessed : 16 November 2024)
IEEE Prerana S. Koke, "Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, pp. 404-415, Nov-Dec 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/Pharmacological_Evaluation_of_Acacetin_Against_Isoproterenol_Induced_Cardiac_Hypertrophy__A_Review_ijariie25312.pdf [Accessed : 16 November 2024].
Turabian Prerana S. Koke. "Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 6 (16 November 2024).
Vancouver Prerana S. Koke. Pharmacological Evaluation of Acacetin Against Isoproterenol-Induced Cardiac Hypertrophy: A Review. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : 16 November 2024]; 10(6) : 404-415. Available from: https://ijariie.com/AdminUploadPdf/Pharmacological_Evaluation_of_Acacetin_Against_Isoproterenol_Induced_Cardiac_Hypertrophy__A_Review_ijariie25312.pdf
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