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Title: :  Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment
PaperId: :  25385
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 6 2024
DUI:    16.0415/IJARIIE-25385
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mehta Drashti AnilkumarSilver Oak University
Dr. Chetana RoatSilver Oak University
Dr. Pranati SarSilver Oak University

Abstract

Cancer Biology, Natural Medicine
TNBC, Stilbenes, Polyphenols, Resveratrol, Anti-cancer activity
Triple Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer defined by the absence of hormone receptors, which presents significant therapeutic challenges. Constituting approximately 10-20% of breast cancer cases, particularly in younger women, TNBC is associated with rapid progression, elevated recurrence rates, and a heightened propensity for metastasis. Current treatment modalities, including chemotherapy, radiotherapy, and surgical interventions, often lead to substantial adverse effects, thereby necessitating the exploration of novel therapeutic strategies. Stilbenes, a class of naturally occurring polyphenolic compounds, have garnered attention for their potential as therapeutic agents against TNBC due to their diverse biological activities, particularly their anticancer properties. Among these, resveratrol is the most extensively investigated, with notable concentrations found in grapes, berries, and red wine. This review comprehensively examines the chemical properties of stilbenes, their multifaceted mechanisms of action—including antioxidant activity, anti-inflammatory effects, and modulation of critical signaling pathways (NF-κB, PI3K/Akt, and Wnt/β-catenin)—and summarizes findings from preclinical studies. By juxtaposing stilbenes with existing treatment modalities, we elucidate their potential advantages and the obstacles to clinical implementation. Ultimately, this review aims to provide insights into the viability of stilbenes as innovative and effective therapeutic options for TNBC, thereby advancing the pursuit of improved patient outcomes.

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IJARIIE Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. "Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 6 2024 Page 960-970
MLA Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. "Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment." International Journal Of Advance Research And Innovative Ideas In Education 10.6(2024) : 960-970.
APA Mehta Drashti Anilkumar, Dr. Chetana Roat, & Dr. Pranati Sar. (2024). Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment. International Journal Of Advance Research And Innovative Ideas In Education, 10(6), 960-970.
Chicago Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. "Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 6 (2024) : 960-970.
Oxford Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. 'Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, 2024, p. 960-970. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Stilbenes__A_Promising_Class_for_Triple_Negative_Breast_Cancer_Treatment_ijariie25385.pdf (Accessed : 08 January 2025).
Harvard Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. (2024) 'Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment', International Journal Of Advance Research And Innovative Ideas In Education, 10(6), pp. 960-970IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Stilbenes__A_Promising_Class_for_Triple_Negative_Breast_Cancer_Treatment_ijariie25385.pdf (Accessed : 08 January 2025)
IEEE Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar, "Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, pp. 960-970, Nov-Dec 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/Stilbenes__A_Promising_Class_for_Triple_Negative_Breast_Cancer_Treatment_ijariie25385.pdf [Accessed : 08 January 2025].
Turabian Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. "Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 6 (08 January 2025).
Vancouver Mehta Drashti Anilkumar, Dr. Chetana Roat, and Dr. Pranati Sar. Stilbenes: A Promising Class for Triple Negative Breast Cancer Treatment. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : 08 January 2025]; 10(6) : 960-970. Available from: https://ijariie.com/AdminUploadPdf/Stilbenes__A_Promising_Class_for_Triple_Negative_Breast_Cancer_Treatment_ijariie25385.pdf
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