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Title: :  FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY
PaperId: :  25421
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 6 2024
DUI:    16.0415/IJARIIE-25421
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
KIRAN RAJKUMAR RAMTIRTHESiddhartha Institute of Pharmacy
PANUGHANTI SUSHMASiddhartha Institute of Pharmacy
SHAILAJA SHAKAPURAMSiddhartha Institute of Pharmacy

Abstract

Pharmacy
Transferosomes, transdermal drug delivery system, antifungal, drug release.
Background: Transferosomes are ultra-deformable lipid vesicles composed of phospholipids, surfactants, and water, designed to enhance the permeability of drugs through the skin and mucosal barriers. The aim of the investigation is to formulate and evaluate the clotrimazole and miconazole-nitrate-loaded transferosomal gel containing antifungal agents for the treatment of fungal infection. Method: The transferosomes were developed using thin film hydration approach and optimized by Box-Behnken statistical design with different concentrations of phospholipids and surfactants like soya lecithin, span 80 and tween 80 as independent factors and Entrapment Efficiency (%), Particle Size (nm), Zeta Potential (mV) as dependent variables. The developed MI-CTM transferosomes were then embedded in the carbopol 934 gel basis, which was assessed for drug content, pH, spreadability, viscosity, and in vitro release kinetic investigations. Results: The high EE% ranged from 15.6 ± 0.66% to 80.25 ± 1.85% for the synthesized transferosomes, while the particle sizes ranged from 145 ± 0.604 nm to 760 ± 0.684 nm, and the zeta potential ranged from -2.8 to -41.8 mV. Transferosomes surface morphology were assessed using a scanning electron microscope, and it was discovered that the vesicles were spherical with smooth surface. The optimal formulation underwent a 24 h in vitro release trial, demonstrating superior drug release of 86.94% and 89.87% CDR with first-order kinetics and Peppas model for miconazole nitrate and clotrimazole, respectively, both of which followed non-Fickian transport mechanism. Conclusion: As a result, both patient compliance and the frequency of drug application are enhanced by miconazole nitrate and clotrimazole in the form of transferosomal gel.

Citations

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IJARIIE KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. "FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 6 2024 Page 1226-1246
MLA KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. "FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY." International Journal Of Advance Research And Innovative Ideas In Education 10.6(2024) : 1226-1246.
APA KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, & SHAILAJA SHAKAPURAM. (2024). FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY. International Journal Of Advance Research And Innovative Ideas In Education, 10(6), 1226-1246.
Chicago KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. "FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 6 (2024) : 1226-1246.
Oxford KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. 'FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, 2024, p. 1226-1246. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/FORMULATION__OPTIMIZATION_AND_IN_VITRO_CHARACTERIZATION_OF_ANTIFUNGAL_TRANSFEROSOMAL_GEL_USING_BOX_BEHNKEN_DESIGN__A_CUTTING_EDGE_APPROACH_TO_DRUG_DELIVERY_ijariie25421.pdf (Accessed : ).
Harvard KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. (2024) 'FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY', International Journal Of Advance Research And Innovative Ideas In Education, 10(6), pp. 1226-1246IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/FORMULATION__OPTIMIZATION_AND_IN_VITRO_CHARACTERIZATION_OF_ANTIFUNGAL_TRANSFEROSOMAL_GEL_USING_BOX_BEHNKEN_DESIGN__A_CUTTING_EDGE_APPROACH_TO_DRUG_DELIVERY_ijariie25421.pdf (Accessed : )
IEEE KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM, "FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 6, pp. 1226-1246, Nov-Dec 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/FORMULATION__OPTIMIZATION_AND_IN_VITRO_CHARACTERIZATION_OF_ANTIFUNGAL_TRANSFEROSOMAL_GEL_USING_BOX_BEHNKEN_DESIGN__A_CUTTING_EDGE_APPROACH_TO_DRUG_DELIVERY_ijariie25421.pdf [Accessed : ].
Turabian KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. "FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 6 ().
Vancouver KIRAN RAJKUMAR RAMTIRTHE, PANUGHANTI SUSHMA, and SHAILAJA SHAKAPURAM. FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF ANTIFUNGAL TRANSFEROSOMAL GEL USING BOX-BEHNKEN DESIGN: A CUTTING-EDGE APPROACH TO DRUG DELIVERY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : ]; 10(6) : 1226-1246. Available from: https://ijariie.com/AdminUploadPdf/FORMULATION__OPTIMIZATION_AND_IN_VITRO_CHARACTERIZATION_OF_ANTIFUNGAL_TRANSFEROSOMAL_GEL_USING_BOX_BEHNKEN_DESIGN__A_CUTTING_EDGE_APPROACH_TO_DRUG_DELIVERY_ijariie25421.pdf
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